2. 疾患モデリングル製品 Others Apoptosis Metabolic Enzyme/Protease Anti-infection
  3. Immunology and Inflammatory Disease Models Fungal Environmental Pollutants Bacterial Endogenous Metabolite Apoptosis
  4. Hapten
  5. Geraniol

ゲラニオール  (Synonyms: Geraniol)

製品番号: HY-N6952 純度: 99.79%
COA 取扱説明書 Technical Support

Geraniol is an olefin terpene with oral activity. Geraniol inhibits cell proliferation and promotes apoptosis. Geraniol has antibacterial, antifungal, antioxidant, anti-inflammatory and antitumor activities. Geraniol can be used to study diabetes.

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Geraniol

ゲラニオール 構造式

CAS 番号 : 106-24-1

容量 価格（税別） 在庫状況 数量
100 mg $55 在庫あり
250 mg $94 在庫あり
500 mg $132 在庫あり
1 g $185 在庫あり
5 g $370 在庫あり
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Based on 2 publication(s) in Google Scholar

Other Forms of Geraniol:

ゲラニオール 関連抗体

Top Publications Citing Use of Products

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Human Endogenous Metabolite Microbial Metabolite

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Geraniol is an olefin terpene with oral activity. Geraniol inhibits cell proliferation and promotes apoptosis. Geraniol has antibacterial, antifungal, antioxidant, anti-inflammatory and antitumor activities. Geraniol can be used to study diabetes[1][2][3][4][5].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
>100 3
Compound: Geraniol
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
[PMID: 25455494]
HEK293 IC50
> 100 3
Compound: Geraniol
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
[PMID: 25455494]
HEK293 IC50
> 100 3
Compound: Geraniol
Antagonist activity against rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
[PMID: 25455494]
HEK293 IC50
> 100 3
Compound: Geraniol
Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
[PMID: 25455494]
体外実験

Geraniol (0.25-1 mM, 24, 48, 72 h) blocks the cell cycle and induces apoptosis in PC-3 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ゲラニオール 関連抗体

Cell Viability Assay [2]

Cell Line: PC-3
Concentration: 0.068, 0.125, 0.25, 0.5, 1 mM
Incubation Time: 72 h
Result: Decreased cell growth in a concentration-dependment manner.

Cell Cycle Analysis [2]

Cell Line: PC-3
Concentration: 0.25, 0.5, 1 mM
Incubation Time: 24 h
Result: Increased the percentage of G1 and/or sub-G1 phase cells.

Western Blot Analysis [2]

Cell Line: PC-3
Concentration: 0.25, 0.5, 1 mM
Incubation Time: 24 h
Result: Increased the activity of caspase-3.
Reduced the expressions of four cyclin isotypes (cyclin A, B, D, and E), two of CDK family (CDK1 and CDK4), and two anti-apoptotic Bcl-2 family members (Bcl-2 and Bcl-w).
Elevated the expressions of two CDK inhibitory proteins (p21 and p27) and two pro-apoptotic Bcl-2 family members (Bax and BNIP3).
体内実験

Geraniol (60, 300 mg/kg, subcutaneously injected into tumor cells daily for 38 consecutive days) inhibits tumor growth in PC-3 nude mouse tumor models[2].
Geraniol (200 mg/kg, orally, for 45 consecutive days) improves hyperglycemia by reducing a key enzyme in carbohydrate metabolism induced by streptomycin (HY-13753) in diabetic rats[3].
Geraniol (100 mg/kg/day, orally, for 4 weeks) alleviates oxidative stress, bioaccumulation, serological and histopathological changes during aluminum chloride hepatopancreas poisoning in male Wistar rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PC-3 cell xenograft in nude mice[2]
Dosage: 60, 300 mg/kg
Administration: s.c.
Result: Reduced the tumor volume and weight.
Increased the percentage of apoptotic cells and reduced the expression level of Ki-67.
Animal Model: Streptozotocin-induced diabetic rats [3]
Dosage: 200 mg/kg
Administration: p.o.
Result: Decreased the body weight in diabetes rats and decreased blood glucose and increased plasma insulin to near normal.
Reverted the levels of Hb and HbA1C towards near normal and reversed the activities of these enzymes to near normal.
Animal Model: Aluminum chloride-hepatopancreatic toxicity rats[4]
Dosage: 100 mg/kg
Administration: p.o.
Result: Reduced AST, ALT, ALP, LDH, pancreatic enzymes and FBS levels.
Reduced the MDA and Increased the TAC levels.
分子量

154.25

分子式

C10H18O
CAS 番号
Appearance

Liquid (Density: 0.879 g/cm3)

Color

Colorless to light yellow

SMILES

C/C(C)=C\CC/C(C)=C/CO
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

H2O : 1 mg/mL (6.48 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.4830 mL 32.4149 mL 64.8298 mL
5 mM 1.2966 mL 6.4830 mL 12.9660 mL
10 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (648.30 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.79%

COA (240 KB) HNMR (242 KB) LCMS (93 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.4830 mL 32.4149 mL 64.8298 mL 162.0746 mL
5 mM 1.2966 mL 6.4830 mL 12.9660 mL 32.4149 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Geraniol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Geraniol106-24-1FungalEnvironmental PollutantsBacterialEndogenous MetaboliteApoptosisEnvironmental ContaminantsAntitumorAnti-inflammationPC-3Prostate cancerDiabetes ratsInhibitorinhibitorinhibit

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