2. Metabolic Enzyme/Protease Membrane Transporter/Ion Channel GPCR/G Protein Apoptosis Immunology/Inflammation
  3. Phosphatase P2X Receptor P2Y Receptor Pyroptosis Interleukin Related
  4. Sodium metatungstate

ポリタングステン酸ナトリウム  (Synonyms: メタタングステン酸ナトリウム; Sodium metatungstate; Sodium polyoxotungstate; POM-1)

製品番号: HY-103259 Assay: 93.4%
COA 取扱説明書 Technical Support

Sodium metatungstate (Sodium polyoxotungstate) is a NTPDase inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively. Sodium metatungstate has anti-inflammatory and anti-cancer effect. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission.

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CAS 番号 : 12141-67-2

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>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 91 在庫あり
Solution
10 mM * 1 mL in DMSO USD 91 在庫あり
Solid
10 mg $28 在庫あり
25 mg $55 在庫あり
50 mg $77 在庫あり
100 mg $108 在庫あり
500 mg $270 在庫あり
1 g   お問い合わせ  
5 g   お問い合わせ  

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カスタマーレビュー

Based on 11 publication(s) in Google Scholar

ポリタングステン酸ナトリウム 関連抗体

Top Publications Citing Use of Products

    Sodium metatungstate purchased from MedChemExpress. Usage Cited in: Int J Nanomedicine. 2025 Jan 27:20:1083-1100.  [Abstract]

    ApoEVs hydrolyze ATP dose-dependently, which can be significantly mitigated by Sodium metatungstate (POM-1, 100 μM).

    Sodium metatungstate purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Jun 24;22(1):364.  [Abstract]

    FTIR spectra of Fe-PDAP, ICG, Sodium metatungstate (POM-1) and FIP.

    Sodium metatungstate purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Jun 24;22(1):364.  [Abstract]

    The photothermal effect of FIP on cancer cells was assessed by flow cytometry. As expected, both FI and FIP displayed obvious cytotoxic toward 4T1 cells when subjected to 808 nm laser irradiation (1.5 W/cm-2, 10 min), suggesting that ICG is responsible for the photothermal killing effect rather than Sodium metatungstate (POM-1).

    Sodium metatungstate purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Jun 24;22(1):364.  [Abstract]

    The Ade level of the FI + Laser group was significantly higher than the control group and FIP + Laser group at 6 h after laser irradiation, indicating the PTT could enhance the Ade generation and Sodium metatungstate (POM-1) could inhibit the Ade generation.

    Sodium metatungstate purchased from MedChemExpress. Usage Cited in: Front Immunol. 2022 Nov 21:13:1026994.

    CD3/CD28-stimulated VPD-stained CD4+ T cells were co-cultured with Treg clones (ratio 1:1) in the presence or not of CD39 and CD73 inhibitors, namely Sodium metatungstate (POM-1, 30 μM) and AB-680 (100 nM), respectively, as indicated. Proliferation was evaluated by VPD dilution.

    P2X Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    P2X1 Receptor P2X2 Receptor P2X3 Receptor P2X4 Receptor P2X7 Receptor

    P2Y Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y11 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

    Interleukin Related アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Sodium metatungstate (Sodium polyoxotungstate) is a NTPDase inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively[1]. Sodium metatungstate has anti-inflammatory and anti-cancer effect. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission[1][2][3][4].

    IC50 & Target

    IL-1β

     

    P2X7 Receptor

     

    体外実験

    Sodium metatungstate (100 μM, 15 min) inhibits the ATP-induced uptake of anionic dyes and the large ATP-induced channels in macrophage[2].
    Sodium metatungstate (100 μM, 8 h) inhibits ATP-induced P2X7-associated pyroptosis in macrophage[2].
    Sodium metatungstate (100 μM, 8-24 h) has a potent anti-inflammatory effect on macrophages[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    ポリタングステン酸ナトリウム 関連抗体
    体内実験

    Sodium metatungstate (5 mg/kg, Intraperitoneal injection, single dose) shows different cytokine/chemokine responses in the peritoneum and systemically in the bloodstream in CD39 knockout mice[3].
    Sodium metatungstate (5 mg/kg, Intraperitoneal injection, once per day from 0 to day 4, day 7-11, and day 14-18.) combine with anti-CD73 antibody and AZD4635(HY-101980) reduces tumor load in multiple myeloma (MM) mice[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Multiple myeloma (MM) mice developed by 3 weeks of injection of 5t33MM cells[4]
    Dosage: 5 mg/kg
    Administration: Intraperitoneal injection (i.p.)
    Result: Had significantly lower spleen weights, fewer tumor cells in the spleen as well as significantly lower monoclonal immunoglobulin component level in circulation.
    分子量

    2986.01

    分子式

    H2Na6O40W12
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    [3Na2WO4.9WO3]
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 50 mg/mL (16.74 mM; Need ultrasonic)

    DMSO : 50 mg/mL (16.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.3349 mL 1.6745 mL 3.3490 mL
    5 mM 0.0670 mL 0.3349 mL 0.6698 mL
    10 mM 0.0335 mL 0.1674 mL 0.3349 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (0.84 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (0.84 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (33.49 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 0.3349 mL 1.6745 mL 3.3490 mL 8.3724 mL
    5 mM 0.0670 mL 0.3349 mL 0.6698 mL 1.6745 mL
    10 mM 0.0335 mL 0.1674 mL 0.3349 mL 0.8372 mL
    15 mM 0.0223 mL 0.1116 mL 0.2233 mL 0.5582 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Sodium metatungstate Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Sodium metatungstate12141-67-2Sodium polyoxotungstate POM-1POM1POM 1POM-1PhosphataseP2X ReceptorP2Y ReceptorPyroptosisInterleukin RelatedP2XRsILmacrophageCD39 knockout miceMultiple myeloma miceInhibitorinhibitorinhibit

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