2. NF-κB Immunology/Inflammation Apoptosis MAPK/ERK Pathway Stem Cell/Wnt Neuronal Signaling Membrane Transporter/Ion Channel
  3. NF-κB COX Apoptosis ERK Calcium Channel
  4. Recoflavone

Recoflavone  (Synonyms: DA-6034 free acid)

製品番号: HY-106449 純度: 98.0%
COA 取扱説明書 Technical Support

Recoflavone (DA-6034 (free acid)), a synthetic derivative of the flavonoid Eupatilin (HY-N0783), is orally active. Recoflavone can inhibit the NF-κB pathway and induce [Ca(2+)]i increase in epithelial cells. Recoflavone exhibits activities such as anti-inflammation, anti-tumor effects, protection of gastric and intestinal mucosa, and promotion of secretion in the ocular surface and salivary glands. Recoflavone can be used for the research of diseases such as dry eye, gastric injury, and intestinal injury.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Recoflavone

Recoflavone 構造式

CAS 番号 : 203191-10-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 183 在庫あり
Solution
10 mM * 1 mL in DMSO USD 183 在庫あり
Solid
5 mg $167 在庫あり
10 mg $268 在庫あり
25 mg $537 在庫あり
50 mg $833 在庫あり
100 mg $1250 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of Recoflavone:

Recoflavone 関連抗体

Top Publications Citing Use of Products

NF-κB アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

COX アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
COX COX-1 COX-2 COX-3

ERK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
ERK ERK1 ERK2 ERK5 ERK8

Calcium Channel アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Recoflavone (DA-6034 (free acid)), a synthetic derivative of the flavonoid Eupatilin (HY-N0783), is orally active. Recoflavone can inhibit the NF-κB pathway and induce [Ca(2+)]i increase in epithelial cells. Recoflavone exhibits activities such as anti-inflammation, anti-tumor effects, protection of gastric and intestinal mucosa, and promotion of secretion in the ocular surface and salivary glands. Recoflavone can be used for the research of diseases such as dry eye, gastric injury, and intestinal injury[1][2][3][4].

体外実験

Recoflavone (100-250 µM; 24-48 h) increases mucin-like glycoprotein secretion in human corneal epithelial cells[1].
Recoflavone (200 µM; 24 h) significantly increases the production of several mucins including MUC1, MUC2, MUC4, MUC5AC, MUC5B and MUC16 in human conjunctival epithelial cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Recoflavone 関連抗体
体内実験

Recoflavone (3%; eye drops; single dose) significantly reduces corneal damage in a rabbit dry eye disease model[1].
Recoflavone (30 mg/kg; oral administration; once every 12 hours; 3 days) exhibits protective effects in a rat small intestinal injury model[2].
Recoflavone (30 mg/kg; oral gavage; twice daily; from day 7 to day 63) shows improvement effects in a mouse colitis-associated cancer model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male New Zealand White rabbits (2.5 kg) with desiccation-induced dry eye by keeping eyes open with a specula for 2 h[1]
Dosage: 3 %
Administration: Eye drops; single dose
Result: Significantly decreased methylene blue permeability in the cornea compared to the vehicle-treated group, indicating prevention of desiccation-induced corneal damage.
Animal Model: Sprague-Dawley rats aged 6 weeks old (250 g) treated Indomethacin (HY-14397) to induce small intestinal injury[2]
Dosage: 30 mg/kg
Administration: Oral administration; once every 12 hours; 3 days
Result: Increased the ERK expression.
Had significantly lower intestinal permeability compared with the control group, while the inflammation scores and the extent of hemorrhagic lesions showed no statistically significant differences.
Animal Model: C57BL/6 mice aged 10 weeks old (18-21 g) treated AOM (HY-111375) and DSS (HY-116282C) to induce colitis-associated cancer[3]
Dosage: 30 mg/kg
Administration: Oral gavage; twice daily; from day 7 to day 63
Result: Reduced the number of colon tumors.
Ameliorated weight loss and colon shortening.
Enhanced apoptosis , and inhibited the expression of proliferation marker Ki-67, COX-2, and phospho-IKKα in colon tissue.
臨床実験
分子量

386.35

分子式

C20H18O8
CAS 番号
Appearance

Solid

Color

Off-white to light yellow

SMILES

COC1=C2C(OC(C3=CC(OC)=C(OC)C=C3)=CC2=O)=CC(OCC(O)=O)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 40 mg/mL (103.53 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5883 mL 12.9416 mL 25.8833 mL
5 mM 0.5177 mL 2.5883 mL 5.1767 mL
10 mM 0.2588 mL 1.2942 mL 2.5883 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5883 mL 12.9416 mL 25.8833 mL 64.7082 mL
5 mM 0.5177 mL 2.5883 mL 5.1767 mL 12.9416 mL
10 mM 0.2588 mL 1.2942 mL 2.5883 mL 6.4708 mL
15 mM 0.1726 mL 0.8628 mL 1.7256 mL 4.3139 mL
20 mM 0.1294 mL 0.6471 mL 1.2942 mL 3.2354 mL
25 mM 0.1035 mL 0.5177 mL 1.0353 mL 2.5883 mL
30 mM 0.0863 mL 0.4314 mL 0.8628 mL 2.1569 mL
40 mM 0.0647 mL 0.3235 mL 0.6471 mL 1.6177 mL
50 mM 0.0518 mL 0.2588 mL 0.5177 mL 1.2942 mL
60 mM 0.0431 mL 0.2157 mL 0.4314 mL 1.0785 mL
80 mM 0.0324 mL 0.1618 mL 0.3235 mL 0.8089 mL
100 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.6471 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Recoflavone Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Recoflavone203191-10-0DA-6034DA6034DA 6034NF-κBCOXApoptosisERKCalcium ChannelNuclear factor-κBNuclear factor-kappaBCyclooxygenaseExtracellular signal regulated kinasesCa2+ channelsCa channelsdry eye disease modelsmall intestinal injury modecolitis-associated cancer modelhuman corneal epithelial cellshuman conjunctival epithelial cellsInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Recoflavone
製品番号:
HY-106449
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.