RN-9893

Cat. No.: HY-110270 Purity: 99.91%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

RN-9893 is a potent and selective TRPV4 receptor antagonist with IC₅₀ values of 320, 420 and 660 nM for mouse, human and rat channels, respectively.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

RN-9893 화학구조

CAS No. : 1803003-68-0

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of RN-9893:

RN-9893 hydrochloride 견적 받기

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

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View All TRP Channel Isoform Specific Products:

View All Isoforms

TRPA1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM8 TRPM2 TRPM3 TRPM4 TRPM7 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

Biological Activity
순도&문서
References
고객리뷰

제품 설명

RN-9893 is a potent and selective TRPV4 receptor antagonist with IC₅₀ values of 320, 420 and 660 nM for mouse, human and rat channels, respectively^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	0.057 3 Compound: 26, RN-9893	Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins	[PMID: 26235950]
HEK293	IC₅₀	30 3 Compound: 26, RN-9893	Antagonist activity at human TRPM8 receptor expressed in HEK293 cells assessed as inhibition of menthol-stimulated calcium flux after 10 mins Antagonist activity at human TRPM8 receptor expressed in HEK293 cells assessed as inhibition of menthol-stimulated calcium flux after 10 mins	[PMID: 26235950]
HEK293	IC₅₀	0.12 3 Compound: 26, RN-9893	Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins	[PMID: 26235950]
HEK293	IC₅₀	>10 3 Compound: 26, RN-9893	Antagonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-stimulated calcium flux after 10 mins Antagonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-stimulated calcium flux after 10 mins	[PMID: 26235950]
HEK293	IC₅₀	0.32 3 Compound: 26, RN-9893	Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins	[PMID: 26235950]
HEK293	IC₅₀	>30 3 Compound: 26, RN-9893	Antagonist activity at human TRPV3 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-stimulated calcium flux after 10 mins Antagonist activity at human TRPV3 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-stimulated calcium flux after 10 mins	[PMID: 26235950]
HEK293	IC₅₀	0.42 3 Compound: 26, RN-9893	Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins	[PMID: 26235950]
HEK293	IC₅₀	0.57 3 Compound: 26, RN-9893	Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of 20% hypotonic solution-induced Ca2+ influx Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of 20% hypotonic solution-induced Ca2+ influx	[PMID: 26235950]
HEK293	IC₅₀	0.42 3 Compound: 26, RN-9893	Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins	[PMID: 26235950]
HEK293	IC₅₀	0.57 3 Compound: 26, RN-9893	Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of 20% hypotonic solution-induced Ca2+ influx Antagonist activity at human TRPV4 expressed in HEK293 cells assessed as inhibition of 20% hypotonic solution-induced Ca2+ influx	[PMID: 26235950]
HEK293	IC₅₀	0.66 3 Compound: 26, RN-9893	Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins	[PMID: 26235950]
HEK293	IC₅₀	0.057 3 Compound: 26, RN-9893	Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins	[PMID: 26235950]
HEK293	IC₅₀	2.1 3 Compound: 26, RN-9893	Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of 20% hypotonic solution-induced Ca2+ influx Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of 20% hypotonic solution-induced Ca2+ influx	[PMID: 26235950]
HEK293	IC₅₀	0.32 3 Compound: 26, RN-9893	Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins Antagonist activity at mouse TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins	[PMID: 26235950]
HEK293	IC₅₀	30 3 Compound: 26, RN-9893	Antagonist activity at human TRPM8 receptor expressed in HEK293 cells assessed as inhibition of menthol-stimulated calcium flux after 10 mins Antagonist activity at human TRPM8 receptor expressed in HEK293 cells assessed as inhibition of menthol-stimulated calcium flux after 10 mins	[PMID: 26235950]
HEK293	IC₅₀	2.1 3 Compound: 26, RN-9893	Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of 20% hypotonic solution-induced Ca2+ influx Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of 20% hypotonic solution-induced Ca2+ influx	[PMID: 26235950]
HEK293	IC₅₀	> 10 3 Compound: 26, RN-9893	Antagonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-stimulated calcium flux after 10 mins Antagonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-stimulated calcium flux after 10 mins	[PMID: 26235950]
HEK293	IC₅₀	0.12 3 Compound: 26, RN-9893	Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of 4alpha-PDD-stimulated calcium flux after 10 mins	[PMID: 26235950]
HEK293	IC₅₀	> 30 3 Compound: 26, RN-9893	Antagonist activity at human TRPV3 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-stimulated calcium flux after 10 mins Antagonist activity at human TRPV3 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-stimulated calcium flux after 10 mins	[PMID: 26235950]
HEK293	IC₅₀	0.66 3 Compound: 26, RN-9893	Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as inhibition of EC80 of 4alpha-PDD-stimulated calcium flux after 10 mins	[PMID: 26235950]

분자량

500.49

화학식

C₂₁H₂₃F₃N₄O₅S

CAS No.

1803003-68-0

Appearance

Solid

Color

White to off-white

SMILES

O=S(C(C=C1)=CC=C1NC(C2=C([N+]([O-])=O)C=C(C(F)(F)F)C=C2)=O)(N3CCN(C(C)C)CC3)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 250 mg/mL (499.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9980 mL	9.9902 mL	19.9804 mL
5 mM	0.3996 mL	1.9980 mL	3.9961 mL
10 mM	0.1998 mL	0.9990 mL	1.9980 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.91%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (255 KB) HNMR (133 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Wei ZL, et, al. Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4011-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9980 mL	9.9902 mL	19.9804 mL	49.9510 mL
	5 mM	0.3996 mL	1.9980 mL	3.9961 mL	9.9902 mL
	10 mM	0.1998 mL	0.9990 mL	1.9980 mL	4.9951 mL
	15 mM	0.1332 mL	0.6660 mL	1.3320 mL	3.3301 mL
	20 mM	0.0999 mL	0.4995 mL	0.9990 mL	2.4976 mL
	25 mM	0.0799 mL	0.3996 mL	0.7992 mL	1.9980 mL
	30 mM	0.0666 mL	0.3330 mL	0.6660 mL	1.6650 mL
	40 mM	0.0500 mL	0.2498 mL	0.4995 mL	1.2488 mL
	50 mM	0.0400 mL	0.1998 mL	0.3996 mL	0.9990 mL
	60 mM	0.0333 mL	0.1665 mL	0.3330 mL	0.8325 mL
	80 mM	0.0250 mL	0.1249 mL	0.2498 mL	0.6244 mL
	100 mM	0.0200 mL	0.0999 mL	0.1998 mL	0.4995 mL

RN-9893 Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RN-98931803003-68-0RN9893RN 9893TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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RN-9893

고객리뷰

Other Forms of RN-9893:

RN-9893 Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All TRP Channel Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

RN-9893 Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report