Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
45 Results for "
CXCR4 receptor
" in MedChemExpress (MCE) Product Catalog:
Products (45)
45 Results for "CXCR4 receptor" in MCE Product Catalog:
6
6 Publications Verification
Target:
Research Areas:
NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046) . NUCC-390 promotes nerve recovery of function after neurodegeneration in vivo .
6
6 Publications Verification
Target:
Research Areas:
NUCC-390 dihydrochloride is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 dihydrochloride induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046) . NUCC-390 dihydrochloride promotes nerve recovery of function after neurodegeneration in vivo .
5
5 Cited Publications
Target:
Research Areas:
ML339 is a selective CXCR6 antagonist with an IC50 of 140 nM. ML339 antagonizes β-arrestin recruitment and cAMP signaling pathway of human CXCR6 receptor induced by CXCL16, with IC50 of 0.3 μM and 1.4 μM, respectively. ML339 shows weaker activity against the recruitment of β-arrestin in mouse CXCR6 receptors, with an IC50 of 18 μM. ML339 has no inhibitory effect on CXCR5，CXCR4，CXCR6 and apelin receptor (APJ), with IC50 >79 μM. ML339 has the potential to promote the development of prostate cancer research .
4
4 Cited Publications
Cat. No.: HY-P0172
CAS No.: 1337878-62-2
Target:
Research Areas:
4
4 Cited Publications
Cat. No.: HY-P0172A
Target:
Research Areas:
2
2
1
1 Cited Publications
Cat. No.: HY-D0976
CAS No.: 202983-32-2
Target:
Research Areas:
NF279 is a selective P2X1 receptor antagonist and NTPDase inhibitor, with a P2X1 IC50 value of 19 nM. NF279 suppresses GABA-evoked currents, reduces ATP-excited respiratory activity, alters hypoglossal nerve burst parameters, and blocks CXCR4, CCR5, CXCR3, and CXCR7-mediated calcium responses. NF279 arrests HIV-1 fusion downstream of CD4 binding, inhibits R5- and X4-tropic HIV-1 strains. NF279 can be used for the research of HIV-1 infection .
1
1 Cited Publications
USL311 is an orally active CXCR4 inhibitor. USL311 blocks the activity of the CXCR4 receptor. USL311 is applicable to research related to various cancers including breast cancer, bladder cancer, colon cancer, rectal cancer, liver cancer and glioblastoma .
1
1 Cited Publications
Cat. No.: HY-P7061A
Target:
Research Areas:
1
Target:
Research Areas:
Cat. No.: HY-P3612
CAS No.: 577782-52-6
Target:
Research Areas:
Cat. No.: HY-161735
CAS No.: 3083908-05-5
Target:
Research Areas:
CXCR4-IN-3 (compound XVI) is an orally active and potent inhibitor targeting the inflammation-related receptor CXCR4, with an IC50 of 3.2 nM. CXCR4-IN-3 exhibits potent antichemotactic activity, at 79.19±2.33% inhibition. CXCR4-IN-3 shows anti-inflammatory activity. CXCR4-IN-3 can be used for IBD (inflammatory bowel disease) research .
Cat. No.: HY-P10427
Target:
Research Areas:
Cat. No.: HY-178205
CAS No.: 2236595-58-5
BPRCX 807 is a selective and potent CXCR4 (CXC chemokine receptor type 4) antagonist. BPRCX 807 inhibits CXCL12-mediated ERK and Akt phosphorylation. BPRCX 807 can significantly suppress primary tumor growth. BPRCX 807 can be used for the study of hepatocellular carcinoma .
Cat. No.: HY-P4109
CAS No.: 265650-93-9
Synonyms: NT21MP; V1 peptide
Target:
Research Areas:
Cat. No.: HY-P11451
CAS No.: 1339959-27-1
Research Areas:
Pentixafor peptide cyclo(dTyr-dOrn(NMe)-R-Nal-G) is a peptide that targets CXCR4. Pentixafor peptide cyclo(dTyr-dOrn(NMe)-R-Nal-G) constitutes the peptide moiety of Pentixafor (HY-153549). Pentixafor is a highly selective cyclic pentapeptide ligand targeting the CXCR4 receptor and is suitable for research into radionuclide-drug conjugates (RDCs) .
Cat. No.: HY-P10427A
Target:
Research Areas:
Cat. No.: HY-162632
CAS No.: 440338-68-1
Research Areas:
Hit 14 is an inhibitor for C-X-C chemokine receptor type 4 (CXCR4) with IC50 of 254 nM. Hit 14 inhibits the migration and invasion of cell MDA-MB-231. Hit 14 inhibits the Akt phosphorylation, exhibits anti-inflammatory activity, and ameliorateds the ear swelling and damage in mouse models .
Cat. No.: HY-P7061
CAS No.: 143413-49-4
Target:
Research Areas:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
