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Cucurbitacin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (10) Autophagy (6) Bacterial (1) CaMK (2) Caspase (3) CDK (2) COX (2) Drug Derivative (3) EGFR (2) Endogenous Metabolite (3) ERK (2) FXR (1) HIF/HIF Prolyl-Hydroxylase (2) HSP (2) Insulin Receptor (1) Integrin (2) JAK (2) MEK (2) Mitochondrial Metabolism (1) p38 MAPK (3) PANoptosis (2) PGC-1α (1) Raf (2) Reference Standards (8) ROS Kinase (2) STAT (4) Stearoyl-CoA Desaturase (SCD) (1) Survivin (2)
By Research Areas:	Cancer (15) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (10) Metabolic Disease (4) Neurological Disease (2)

By Targets:

Akt (1)

Apoptosis (10)

Autophagy (6)

Bacterial (1)

CaMK (2)

Caspase (3)

CDK (2)

COX (2)

Drug Derivative (3)

EGFR (2)

Endogenous Metabolite (3)

ERK (2)

FXR (1)

HIF/HIF Prolyl-Hydroxylase (2)

HSP (2)

Insulin Receptor (1)

Integrin (2)

JAK (2)

MEK (2)

Mitochondrial Metabolism (1)

p38 MAPK (3)

PANoptosis (2)

PGC-1α (1)

Raf (2)

Reference Standards (8)

ROS Kinase (2)

STAT (4)

Stearoyl-CoA Desaturase (SCD) (1)

Survivin (2)

By Research Areas:

Cancer (15)

Cardiovascular Disease (1)

Infection (2)

Inflammation/Immunology (10)

Metabolic Disease (4)

Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0416

Cucurbitacin B 10+ Cited Publications	HIF/HIF Prolyl-Hydroxylase Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX	Others Neurological Disease Inflammation/Immunology Cancer
Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .

HY-N1405

Cucurbitacin I Maximum Cited Publications 13 Publications Verification Elatericin B; JSI-124; NSC-521777	STAT JAK	Cancer
Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.

HY-N1986

Cucurbitacin D	HSP Apoptosis	Inflammation/Immunology Cancer
Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis, exhibiting anti-tumor and anti-inflammatory effects .

HY-N1988

Cucurbitacin IIa 1 Publications Verification Hemslecin A	Survivin Apoptosis EGFR Caspase p38 MAPK Autophagy MEK Raf ERK STAT CaMK	Inflammation/Immunology Cancer
Cucurbitacin IIa (Hemslecin A) is an orally active, blood-brain barrier-permeable EGFR inhibitor with an IC₅₀ of 1.455 nM against human EGFR. Cucurbitacin IIa induces caspase-3-dependent apoptosis, downregulates survivin expression, enhances autophagy levels, disrupts the actin cytoskeleton via actin aggregation, arrests the cell cycle at the G2/M phase, and exerts anti-inflammatory activity by inhibiting the EGFR-MAPK signaling pathway. Cucurbitacin IIa can be used in the research of inflammation-related diseases, depression, and cancers such as non-small cell lung cancer .

HY-N0417

Cucurbitacin E 5+ Cited Publications α-Elaterin; α-Elaterine	CDK Autophagy PANoptosis	Metabolic Disease Inflammation/Immunology Cancer
Cucurbitacin E is a CDK1 inhibitor that significantly inhibits the activity of the cyclin B1/CDC2 complex. Cucurbitacin E also induces PANoptosis in adrenocortical carcinoma cells in a ZBP1-dependent manner. Cucurbitacin E exhibits synergistic effects with Mitotane (HY-13690); when used in combination, they effectively eliminate tumors .

HY-N6579

Arvenin I	p38 MAPK Mitochondrial Metabolism	Cancer
Arvenin I is a natural cucurbitacin glucoside that activates T cells within the cancer-competitive environment. Arvenin I covalently reacts with and hyperactivates MKK3, thereby reviving the mitochondrial fitness of exhausted T cells through the activation of the p38MAPK pathway . Arvenin I exhibits broad-spectrum antiproliferative against cancer cells . Arvenin I enhances antitumor effects both as a monotherapy and in combination with immune checkpoint inhibitors in mice . Arvenin I can be used for cancer research, such as colon cancer, breast cancer, lung cancer, and ovarian cancer ^[1][2].

HY-156110

IGF2BP1-IN-1	Insulin Receptor	Cancer
IGF2BP1-IN-1 (Compound A11) is a IGF2BP1 inhibitor and inhibits downstream signaling. IGF2BP1-IN-1 binds to IGF2BP1 protein with a K_D value of 2.88 nM. IGF2BP1-IN-1 inhibits cancer cells proliferation (IC₅₀: 9 nM for A549 cell, 34 nM for HCT116). IGF2BP1-IN-1 induces cancer cell apoptosis. GF2BP1-IN-1 inhibits tumor growth in A549 xenograft mouse model .

HY-N12461

Cucurbitacin F	Bacterial Caspase Apoptosis	Infection
Cucurbitacin F is a tetracyclic protostane-type triterpenoid with low toxicity, antibacterial and anti-inflammatory activities, and is also a related compound of Cucurbitacin B (HY-N0416). Cucurbitacin F widely exists in plants such as Cucurbitaceae plants, Quisqualis indica and Sorbaria sorbifolia. Cucurbitacin F acts as an actin aggregator and reduces cell viability in a dose-dependent manner. Cucurbitacin F induces apoptosis by triggering G2/M phase cell cycle arrest and activating the caspase-3-dependent apoptosis .

HY-N1987

Cucurbitacin IIb 2 Publications Verification	Apoptosis	Inflammation/Immunology
Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α .

HY-N8137

Cucurbitacin Q1	Others	Others
Cucurbitacin Q1 is a tetracyclic triterpene that can be found in Cucumis prophetarum .

HY-N11080

Cucurbitacin R	Others	Inflammation/Immunology
Cucurbitacin R is a cucurbitacin. Cucurbitacin R can be isolated from the roots of Cayaponia tayuya. Cucurbitacin R can be used for the research of pain and inflammation .

HY-N11081

Hexanorcucurbitacin D	FXR	Cardiovascular Disease
Hexanorcucurbitacin D, a cucurbitacin, is a weak ecdysteroid receptor agonist. Hexanorcucurbitacin D can be isolated from Trichosanthes cucumeroides roots. Hexanorcucurbitacin D can be used for the research of cardiovascular disease (CVD) .

HY-N10685

3,7,25-Trihydroxycucurbita-5,23-dien-19-al TCD	Drug Derivative	Others Cancer
3,7,25-Trihydroxycucurbita-5,23-dien-19-al (TCD) is a natural product, that can be isolated from the chloroform extract of the leaves of Momordica foetida .

HY-N0416R

Cucurbitacin B (Standard)	HIF/HIF Prolyl-Hydroxylase Reference Standards Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX	Others Neurological Disease Inflammation/Immunology Cancer
Cucurbitacin B (Standard) is the analytical standard of Cucurbitacin B. This product is intended for research and analytical applications. Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .

HY-N9968

Cucurbitacin C	Akt Apoptosis	Cancer
Cucurbitacin C is a triterpenoid calabinoid that can be isolated from Cucurbitaceae plants. Cucurbitacin C has anti-cancer activity in vivo and in vitro. Cucurbitacin C can induce cell cycle arrest in G1 or G2/M phase and apoptosis by inhibiting Akt signaling .

HY-N0417R

Cucurbitacin E (Standard) α-Elaterin (Standard); α-Elaterine (Standard)	Reference Standards CDK Autophagy PANoptosis	Cancer
Cucurbitacin E (Standard) is the analytical standard of Cucurbitacin E. This product is intended for research and analytical applications. Cucurbitacin E is a natural compound which from Cucurbitaceae plants. Cucurbitacin E significantly suppresses the activity of the cyclin B1/CDC2 complex.

HY-N12552

Cucurbitacin IIa 2-O-β-D-glucoside Hemslecin A 2-O-β-d-glucopyranoside	Others	Infection
Cucurbitacin IIa 2-O-β-D-glucoside is a glycoside cucurbitacin isolated from the genus Hemsleya (Cucurbitaceae). Extracts of Hemsleya have the potential to be used in research on bronchitis, bacillary dysentery, and tuberculosis .

HY-N12011

11-Oxoisomogroside V	PGC-1α	Others
11-Oxoisomogroside V (compound 3) is a cucurbitacin isolated from the crude extract of Luo Han Guo. 11-Oxoisomogroside V activates the transcriptional activity of PGC-1α. In the luciferase experiment, the results showed that 10 μM and 20 μM 11-Oxoisomogroside V could increase the luciferase activity to 133.79% and 143.81% .

HY-N1986R

Cucurbitacin D (Standard)	Reference Standards HSP Apoptosis	Inflammation/Immunology Cancer
Cucurbitacin D (Standard) is the analytical standard of Cucurbitacin D. This product is intended for research and analytical applications. Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis, exhibiting anti-tumor and anti-inflammatory effects .

HY-N1987R

Cucurbitacin IIb (Standard)	Reference Standards Apoptosis	Inflammation/Immunology
Cucurbitacin IIb (Standard) is the analytical standard of Cucurbitacin IIb. This product is intended for research and analytical applications. Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α .

HY-N4175

Cucurbitacin A	Others	Cancer
Cucurbitacin A, a triterpenoid that could be isolated from the Stems of Cucumis melo, shows anti-cancer activity .

HY-N1988R

Cucurbitacin IIa (Standard) Hemslecin A (Standard)	Reference Standards Apoptosis EGFR Autophagy MEK Caspase ERK STAT Survivin Raf p38 MAPK CaMK	Inflammation/Immunology Cancer
Cucurbitacin IIa (Hemslecin A) (Standard) is the analytical standard for Cucurbitacin IIa (HY-N1988). This product is used for research and analytical applications. Cucurbitacin IIa is an orally active, blood-brain barrier-penetrating EGFR inhibitor with an IC₅₀ of 1.455 nM for human EGFR. Cucurbitacin IIa induces caspase-3 dependent cell apoptosis, downregulates survivin expression, enhances autophagy levels, disrupts the actin cytoskeleton through actin aggregation, blocks the cell cycle at the G2/M phase, and inhibits the EGFR-MAPK signaling pathway to exert anti-inflammatory activity. Cucurbitacin IIa can be used in research on inflammatory-related diseases, depression, and non-small cell lung cancer and other cancers.

HY-N1405R

Cucurbitacin I (Standard) Elatericin B (Standard); JSI-124 (Standard); NSC-521777 (Standard)	STAT JAK Reference Standards	Cancer
Cucurbitacin I (Standard) is the analytical standard of Cucurbitacin I. This product is intended for research and analytical applications. Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.

HY-19796R

Icomidocholic acid (Standard) Aramchol (Standard); C20-FABAC (Standard)	Reference Standards Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
Cucurbitacin D (Standard) is the analytical standard of Cucurbitacin D. This product is intended for research and analytical applications. Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis, exhibiting anti-tumor and anti-inflammatory effects .

HY-N8288

Momordicoside F1	Others	Others
Momordicoside F1 is a triterpenoid that can be isolated from Momordica charantia .

HY-N13811

Cucurbitacin V	Drug Derivative	Others
Cucurbitacin V is a natural triterpene.

HY-N12474

*2-epi-Cucurbitacin* B**	Others	Others
2-epi-Cucurbitacin B is a natural product that can be obtained from Ecballium elaterium L. XVI. .

HY-N9827

Cucurbitacin A 2-O-β-D-glucopyranoside	Drug Derivative	Others
Cucurbitacin A 2-O-β-D-glucopyranoside is a natural triterpene.

HY-N2362R

DL-Alanine (Standard) DL-2-Aminopropionic acid (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Cucurbitacin IIb (Standard) is the analytical standard of Cucurbitacin IIb. This product is intended for research and analytical applications. Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α .

HY-N11089

23,24-Dihydroisocucurbitacin D	Others	Metabolic Disease
23,24-Dihydroisocucurbitacin D (compound 22) is a cucurbitacin .

HY-N12585

Picfeltarraegenin I	Others	Others
Picfeltarraegenin I (Compound 2) is a cucurbitacin that can be isolated from Picria fel-terrae Lour .

HY-N12551

2-O-β-D-Glucopyranosylcucurbitacin F 25-acetate	Others	Others
2-O-β-D-Glucopyranosylcucurbitacin F 25-acetate is a cucurbitacin glucoside that can isolated from the more polar fractions of the MeOH extract of Cigarrilla mexicana .

Cucurbitacin B 10+ Cited Publications	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Trichosanthes cucumerina L. Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	HIF/HIF Prolyl-Hydroxylase Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX
Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .

Cucurbitacin I Maximum Cited Publications 13 Publications Verification Elatericin B; JSI-124; NSC-521777	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Plants Disease Research Fields Lagenaria siceraria (Molina) Standl. Cancer	STAT JAK
Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.

Cucurbitacin D	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Trichosanthes kirilowii Maxim. Plants Disease Research Fields Source Classification Cancer	HSP Apoptosis
Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis, exhibiting anti-tumor and anti-inflammatory effects .

Cucurbitacin IIa 1 Publications Verification Hemslecin A	Triterpenes Structural Classification Classification of Application Fields Terpenoids Cucurbitaceae Plants Hemsleya chinensis Cogn. ex Forbes et Hemsl. Disease Research Fields Source Classification Cancer	Survivin Apoptosis EGFR Caspase p38 MAPK Autophagy MEK Raf ERK STAT CaMK
Cucurbitacin IIa (Hemslecin A) is an orally active, blood-brain barrier-permeable EGFR inhibitor with an IC₅₀ of 1.455 nM against human EGFR. Cucurbitacin IIa induces caspase-3-dependent apoptosis, downregulates survivin expression, enhances autophagy levels, disrupts the actin cytoskeleton via actin aggregation, arrests the cell cycle at the G2/M phase, and exerts anti-inflammatory activity by inhibiting the EGFR-MAPK signaling pathway. Cucurbitacin IIa can be used in the research of inflammation-related diseases, depression, and cancers such as non-small cell lung cancer .

Cucurbitacin E 5+ Cited Publications α-Elaterin; α-Elaterine	Triterpenes Structural Classification Classification of Application Fields Terpenoids Cucurbitaceae Plants Disease Research Fields Source Classification Cancer	CDK Autophagy PANoptosis
Cucurbitacin E is a CDK1 inhibitor that significantly inhibits the activity of the cyclin B1/CDC2 complex. Cucurbitacin E also induces PANoptosis in adrenocortical carcinoma cells in a ZBP1-dependent manner. Cucurbitacin E exhibits synergistic effects with Mitotane (HY-13690); when used in combination, they effectively eliminate tumors .

Arvenin I	Structural Classification Terpenoids Scrophulariaceae Diterpenoids Lagotis yunnanensis W. W. Smith Plants	p38 MAPK Mitochondrial Metabolism
Arvenin I is a natural cucurbitacin glucoside that activates T cells within the cancer-competitive environment. Arvenin I covalently reacts with and hyperactivates MKK3, thereby reviving the mitochondrial fitness of exhausted T cells through the activation of the p38MAPK pathway . Arvenin I exhibits broad-spectrum antiproliferative against cancer cells . Arvenin I enhances antitumor effects both as a monotherapy and in combination with immune checkpoint inhibitors in mice . Arvenin I can be used for cancer research, such as colon cancer, breast cancer, lung cancer, and ovarian cancer ^[1][2].

Cucurbitacin F	Triterpenes Structural Classification Hemsleya gigantha W. J. Chang Terpenoids Cucurbitaceae Plants Source Classification	Bacterial Caspase Apoptosis
Cucurbitacin F is a tetracyclic protostane-type triterpenoid with low toxicity, antibacterial and anti-inflammatory activities, and is also a related compound of Cucurbitacin B (HY-N0416). Cucurbitacin F widely exists in plants such as Cucurbitaceae plants, Quisqualis indica and Sorbaria sorbifolia. Cucurbitacin F acts as an actin aggregator and reduces cell viability in a dose-dependent manner. Cucurbitacin F induces apoptosis by triggering G2/M phase cell cycle arrest and activating the caspase-3-dependent apoptosis .

Cucurbitacin IIb 2 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Plants Hemsleya amabilis Diels Inflammation/Immunology Disease Research Fields	Apoptosis
Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α .

Cucurbitacin Q1	Triterpenes other families Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Source Classification	Others
Cucurbitacin Q1 is a tetracyclic triterpene that can be found in Cucumis prophetarum .

Cucurbitacin R	Triterpenes Terpenoids Cucurbitaceae Cayaponia tayuya Plants Source Classification	Others
Cucurbitacin R is a cucurbitacin. Cucurbitacin R can be isolated from the roots of Cayaponia tayuya. Cucurbitacin R can be used for the research of pain and inflammation .

Hexanorcucurbitacin D	Triterpenes Terpenoids Cucurbitaceae Trichosanthes cucumeroides (Ser.) Maxim. Plants Source Classification	FXR
Hexanorcucurbitacin D, a cucurbitacin, is a weak ecdysteroid receptor agonist. Hexanorcucurbitacin D can be isolated from Trichosanthes cucumeroides roots. Hexanorcucurbitacin D can be used for the research of cardiovascular disease (CVD) .

3,7,25-Trihydroxycucurbita-5,23-dien-19-al TCD	Triterpenes Structural Classification Anthocyans Flavonoids Terpenoids Cucurbitaceae Plants Momordica charantia Linn. Source Classification	Drug Derivative
3,7,25-Trihydroxycucurbita-5,23-dien-19-al (TCD) is a natural product, that can be isolated from the chloroform extract of the leaves of Momordica foetida .

Cucurbitacin B (Standard)	Triterpenes Structural Classification Terpenoids Cucurbitaceae Trichosanthes cucumerina L. Plants Endogenous metabolite Source Classification	HIF/HIF Prolyl-Hydroxylase Reference Standards Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX
Cucurbitacin B (Standard) is the analytical standard of Cucurbitacin B. This product is intended for research and analytical applications. Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .

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Inhibitors & Agonists

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