Art. -Nr.: HY-156110

IGF2BP1-IN-1

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IGF2BP1-IN-1 (Compound A11) is a IGF2BP1 inhibitor and inhibits downstream signaling. IGF2BP1-IN-1 binds to IGF2BP1 protein with a K_D value of 2.88 nM. IGF2BP1-IN-1 inhibits cancer cells proliferation (IC₅₀: 9 nM for A549 cell, 34 nM for HCT116). IGF2BP1-IN-1 induces cancer cell apoptosis. GF2BP1-IN-1 inhibits tumor growth in A549 xenograft mouse model.

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Reinheit: 99.94%
CAS. Nr.: 3029447-08-0
Formel: C₄₂H₅₂FN₃O₁₀
Molecular Weight:777.87

Speicherung:

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

IGF2BP1-IN-1 Chemical Structure

CAS. Nr.: 3029447-08-0

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

KD: 2.88 nM (IGF2BP1)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.009 μM Compound: A11	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37681508]
A549	IC₅₀	5 nM Compound: A11	Antiproliferative activity against wild type human A549 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Antiproliferative activity against wild type human A549 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37681508]
A549	IC₅₀	92 nM Compound: A11	Antiproliferative activity against human A549 cells with IGF2BP1 knockdown assessed as cell growth inhibition incubated for 72 hrs by SRB assay Antiproliferative activity against human A549 cells with IGF2BP1 knockdown assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37681508]
BXPC-3	IC₅₀	0.018 μM Compound: A11	Antiproliferative activity against human BXPC-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Antiproliferative activity against human BXPC-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37681508]
CFPAC-1	IC₅₀	0.037 μM Compound: A11	Antiproliferative activity against human CFPAC-1 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Antiproliferative activity against human CFPAC-1 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37681508]
HCT-116	IC₅₀	0.034 μM Compound: A11	Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37681508]
HeLa	IC₅₀	0.015 μM Compound: A11	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37681508]
HepG2	IC₅₀	0.08 μM Compound: A11	Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37681508]
L02	IC₅₀	0.1 μM Compound: A11	Antiproliferative activity against human L02 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Antiproliferative activity against human L02 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37681508]
MCF7	IC₅₀	0.056 μM Compound: A11	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37681508]
MDA-MB-231	IC₅₀	0.049 μM Compound: A11	Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37681508]
PANC-1	IC₅₀	0.088 μM Compound: A11	Antiproliferative activity against human PANC-1 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Antiproliferative activity against human PANC-1 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37681508]
SK-OV-3	IC₅₀	0.054 μM Compound: A11	Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37681508]

Chemical Information

CAS. Nr. 3029447-08-0
Appearance Solid
Molecular Weight 777.87
Formel C₄₂H₅₂FN₃O₁₀
Color White to off-white
SMILES

C[C@]12[C@@]3([H])[C@]([C@@]4([H])C(C(C)(C([C@H](C4)OC(CN5C(N(C6=CC=C(C=C6)F)C=N5)=O)=O)=O)C)=CC3)(C(C[C@@]1([C@@]([C@@H](C2)O)([H])[C@@](C)(O)C(/C=C/C(C)(C)OC(C)=O)=O)C)=O)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (128.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.2856 mL

6.4278 mL

12.8556 mL

5 mM

0.2571 mL

1.2856 mL

2.5711 mL

10 mM

0.1286 mL

0.6428 mL

1.2856 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Shang FF, et al. Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer. J Med Chem. 2023 Sep 8. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.2856 mL	6.4278 mL	12.8556 mL	32.1390 mL
	5 mM	0.2571 mL	1.2856 mL	2.5711 mL	6.4278 mL
	10 mM	0.1286 mL	0.6428 mL	1.2856 mL	3.2139 mL
	15 mM	0.0857 mL	0.4285 mL	0.8570 mL	2.1426 mL
	20 mM	0.0643 mL	0.3214 mL	0.6428 mL	1.6070 mL
	25 mM	0.0514 mL	0.2571 mL	0.5142 mL	1.2856 mL
	30 mM	0.0429 mL	0.2143 mL	0.4285 mL	1.0713 mL
	40 mM	0.0321 mL	0.1607 mL	0.3214 mL	0.8035 mL
	50 mM	0.0257 mL	0.1286 mL	0.2571 mL	0.6428 mL
	60 mM	0.0214 mL	0.1071 mL	0.2143 mL	0.5357 mL
	80 mM	0.0161 mL	0.0803 mL	0.1607 mL	0.4017 mL
	100 mM	0.0129 mL	0.0643 mL	0.1286 mL	0.3214 mL

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IGF2BP1-IN-1

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Metabolic Enzyme Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Brain Cancer Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

IGF2BP1-IN-1

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Metabolic Enzyme Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Brain Cancer Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

IGF2BP1-IN-1 Related Classifications

HY-156110 Related Classifications