2. Protein Tyrosine Kinase/RTK
  3. Insulin Receptor
  4. IGF2BP1-IN-1

IGF2BP1-IN-1 (Compound A11) is a IGF2BP1 inhibitor and inhibits downstream signaling. IGF2BP1-IN-1 binds to IGF2BP1 protein with a KD value of 2.88 nM. IGF2BP1-IN-1 inhibits cancer cells proliferation (IC50: 9 nM for A549 cell, 34 nM for HCT116). IGF2BP1-IN-1 induces cancer cell apoptosis. GF2BP1-IN-1 inhibits tumor growth in A549 xenograft mouse model.

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IGF2BP1-IN-1 Chemical Structure

IGF2BP1-IN-1 Chemical Structure

CAS No. : 3029447-08-0

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IGF2BP1-IN-1 Related Antibodies

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Description

IGF2BP1-IN-1 (Compound A11) is a IGF2BP1 inhibitor and inhibits downstream signaling. IGF2BP1-IN-1 binds to IGF2BP1 protein with a KD value of 2.88 nM. IGF2BP1-IN-1 inhibits cancer cells proliferation (IC50: 9 nM for A549 cell, 34 nM for HCT116). IGF2BP1-IN-1 induces cancer cell apoptosis. GF2BP1-IN-1 inhibits tumor growth in A549 xenograft mouse model[1].

IC50 & Target

KD: 2.88 nM (IGF2BP1)[1]
Molecular Weight

777.87

Formula

C42H52FN3O10
CAS No.
SMILES

C[C@]12[C@@]3([H])[C@]([C@@]4([H])C(C(C)(C([C@H](C4)OC(CN5C(N(C6=CC=C(C=C6)F)C=N5)=O)=O)=O)C)=CC3)(C(C[C@@]1([C@@]([C@@H](C2)O)([H])[C@@](C)(O)C(/C=C/C(C)(C)OC(C)=O)=O)C)=O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IGF2BP1-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IGF2BP1-IN-13029447-08-0Insulin ReceptorcancertumorCucurbitacin BA549HCT116A549 xenograft， NSCLCInhibitorinhibitorinhibit

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