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Results for "

Glycyrrhiza uralensis

" in MedChemExpress (MCE) Product Catalog:

33

Inhibitors & Agonists

31

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N9919
    Glyasperin C

    		Others Others
    Glyasperin C is a potent and reversible noncompetitive inhibitor of neuraminidase with an IC50 of 20% at 200 μM. Glyasperin C is a polyphenol isolated from the roots of Glycyrrhiza uralensis .
    Glyasperin C
  • HY-N2122
    Neoisoliquiritin

    Neoisoliquiritigenin
    Neoisoliquiritin is a bioactive component isolated from Glycyrrhiza uralensis .
    Neoisoliquiritin
  • HY-N2123
    Neoliquiritin

    		Others Inflammation/Immunology
    Neoliquiritin is isolated from Glycyrrhiza uralensis with an anti-inflammatory activity .
    Neoliquiritin
  • HY-N8609
    Uralsaponin C

    		Others Others
    Uralsaponin C is an analogue of oleanane-type triterpenoid saponin. Uralsaponin C can be isolated from the roots of Glycyrrhiza uralensis Fisch .
    Uralsaponin C
  • HY-N3920
    Gancaonin G

    		Bacterial Infection
    Gancaonin G is a 6-prenylated isoflavanone that can be isolated from Glycyrrhiza uralensis. Gancaonin G has antibacterial activity against Streptococcus mutants and MRSA strains .
    Gancaonin G
  • HY-142096
    Glycyuralin E

    		Others Others
    Glycyuralin E is a natural product that can be isolated from Glycyrrhiza uralensis .
    Glycyuralin E
  • HY-N6981
    Methyl Glycyrrhizate

    		Others Metabolic Disease Cancer
    Methyl Glycyrrhizate, derived from Glycyrrhiza uralensis Fisch., is the ester of methyl alcohol and Glycyrrhizic Acid .
    Methyl Glycyrrhizate
  • HY-N6975
    Glyasperin D

    		Bacterial Infection
    Glyasperin D is a flavonoid isolated from Glycyrrhiza uralensis, and possesses weaker anti-Helicobacter pylori activity .
    Glyasperin D
  • HY-N3385
    Licorisoflavan A

    7-O-Methyllicorisoflavan B

    		 Others Others
    Licorisoflavan A (7-O-Methyllicorisoflavan B) is a isoflavan-quinone, that can be isolated from Glycyrrhiza uralensis .
    Licorisoflavan A
  • HY-N0180
    18β-Glycyrrhetinic acid
    5+ Cited Publications

    		 Endogenous Metabolite Inflammation/Immunology Cancer
    18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
    18β-Glycyrrhetinic acid
  • HY-N4186
    Glabrolide

    		Beta-secretase Neurological Disease
    Glabrolide, derived from Glycyrrhiza uralensis Fisch., is a β-secretase 1 (BACE-1) inhibitor[1].
    Glabrolide
  • HY-N6583
    Licoflavonol

    		Bacterial Infection
    Licoflavonol, a minor flavone from the roots of Glycyrrhiza uralensis, is an inhibitor of the Salmonella type III secretion system (T3SS) .
    Licoflavonol
  • HY-N6911
    Licorice-saponin H2

    (18β,20α)-Glycyrrhizic acid

    		 Others Metabolic Disease
    Licorice-saponin H2 ((18β,20α)-Glycyrrhizic acid) is a saponin from Glycyrrhiza uralensis Fischer .
    Licorice-saponin H2
  • HY-W049311
    4-Methyl-5,6,7,8-tetrahydroquinoline

    		Others Others
    4-Methyl-5,6,7,8-tetrahydroquinoline, a tetrahydroquinoline alkaloid, is isolated from the roots of Glycyrrhiza uralensis Fisch .
    4-Methyl-5,6,7,8-tetrahydroquinoline
  • HY-N0377
    Liquiritigenin
    2 Publications Verification

    4',7-Dihydroxyflavanone

    		 Estrogen Receptor/ERR Neurological Disease Inflammation/Immunology Cancer
    Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC50 of 36.5 nM for activation of the ERE tk-Luc.
    Liquiritigenin
  • HY-N4182
    Licochalcone E

    		Akt p38 MAPK Autophagy Inflammation/Immunology
    Licochalcone E, a flavonoid compound isolated from Glycyrrhiza uralensis, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation .
    Licochalcone E
  • HY-N6989
    Isoglycycoumarin

    		Cytochrome P450 Metabolic Disease
    Isoglycycoumarin is a flavonoid isolated from the roots of Glycyrrhiza uralensis. Isoglycycoumarin is a highly selective probe for human cytochrome P450 2A6 (CYP2A6) .
    Isoglycycoumarin
  • HY-N11771
    Glyurallin B

    		Others Others
    Glyurallin B is a flavonoid, that can be isolated from licorice (Glycyrrhiza inflata and Glycyrrhiza uralensis). Glyurallin B shows ABTS + radical scavenging activity and the inhibitory activity on lipid peroxidation, with EC50 values of 11.9 ± 0.58 μM and 15.3 ± 1.26 μM, respectivley .
    Glyurallin B
  • HY-N4185
    Licoflavone A
    1 Publications Verification

    		 Phosphatase Neurological Disease
    Licoflavone A is a flavonoid isolated from the roots of Glycyrrhiza uralensis, inhibits protein tyrosine phosphatase-1B (PTP1B), with an IC50 of 54.5 μM .
    Licoflavone A
  • HY-N8947
    Glyurallin A

    		Endogenous Metabolite Glucosidase Metabolic Disease
    Glyurallin A (Compound 79) is isolated from the naturalGlycyrrhiza uralensis. Glyurallin A inhibitsα-Glucosidase(HY-P2802)(IC50=0.3 μM). Glyurallin A can be used in the study of anti-diabetes .
    Glyurallin A
  • HY-N0102
    Isoliquiritigenin
    Maximum Cited Publications
    15 Publications Verification

    GU17; ISL; Isoliquiritigen; SJ000286237

    		 Aldose Reductase Influenza Virus Autophagy Apoptosis Infection Inflammation/Immunology Cancer
    Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM.
    Isoliquiritigenin
  • HY-N3961
    Neoglycyrol

    		Others Cardiovascular Disease
    Neoglycyrol is isolated from the root of Glycyrrhiza uralensis Fisch . Neoglycyrol is a potential myocardial protection active compound screened from traditional patent medicine Tongmai Yangxin pill (TMYXP) .
    Neoglycyrol
  • HY-121054
    Chalcone

    		Bacterial Parasite Inflammation/Immunology Cancer
    Chalcone is isolated from Glycyrrhiza uralensis and used to synthesize chalcone derivatives. Chalcone derivatives possess varied biological and pharmacological activity, including anti-inflammatory, antioxidative, antibacterial, anticancer, and anti-parasitic activities .
    Chalcone
  • HY-N4187
    Licochalcone D
    1 Publications Verification

    		 NF-κB Apoptosis Reactive Oxygen Species Metabolic Disease Inflammation/Immunology Cancer
    Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza uralensis, is a potent and orally active inhibitor of NF-kappaB (NF-κB) p65. Licochalcone D possesses antioxidant, anti-inflammatory, anti-cancer properties .
    Licochalcone D
  • HY-N6980
    Licorice glycoside C2
    1 Publications Verification

    		 HIV Infection Cancer
    Licorice glycoside C2 is a oleanane-type triterpene oligoglycoside isolated from Glycyrrhiza uralensis. Various biological activities are associated with licorice extracts, such as anti-viral, anti-microbial, antioxidant, anti-inflammatory, anti-ulcer, anti-cancer and anti-HIV effects .
    Licorice glycoside C2
  • HY-N0393
    Glabridin
    1 Publications Verification

    		 PPAR Reactive Oxygen Species Bacterial Infection Inflammation/Immunology Cancer
    Glabridin is a natural isoflavan from Glycyrrhiza uralensis, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities .
    Glabridin
  • HY-N1280
    Semilicoisoflavone B

    		Amyloid-β Neurological Disease
    Semilicoisoflavone B, an isoflavone, mainly derived from Glycyrrhiza uralensis Fisch.. Semilicoisoflavone B reduces amyloid β (Aβ) secretion by inhibiting β-secretase-1 (BACE1) expression and activity. Semilicoisoflavone B decreases BACE1 expression mainly through increasing PPARγ expression and inhibiting STAT3 phosphorylation .
    Semilicoisoflavone B
  • HY-N0393R
    Glabridin (Standard)

    		PPAR Reactive Oxygen Species Bacterial Infection Inflammation/Immunology Cancer
    Glabridin (Standard) is the analytical standard of Glabridin. This product is intended for research and analytical applications. Glabridin is a natural isoflavan from Glycyrrhiza uralensis, binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities .
    Glabridin (Standard)
  • HY-N3716
    Dehydroglyasperin D

    		Aldose Reductase COX Metabolic Disease Inflammation/Immunology
    Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50: 62.4 μM and 176.2 μM respectively). Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi .
    Dehydroglyasperin D
  • HY-N0376
    Liquiritin
    5 Publications Verification

    		 Reactive Oxygen Species Neurological Disease Inflammation/Immunology Cancer
    Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .
    Liquiritin
  • HY-N0373
    Licochalcone B
    4 Publications Verification

    		 Amyloid-β Apoptosis NOD-like Receptor (NLR) Neurological Disease
    Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction .
    Licochalcone B
  • HY-N3387
    Licoricidin

    		Apoptosis NF-κB Akt MMP Inflammation/Immunology Cancer
    Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC50=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer . Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect . Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo . Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations .
    Licoricidin
  • HY-N2609
    7,4'-Dihydroxyflavone
    1 Publications Verification

    		 CCR NF-κB Inflammation/Immunology Endocrinology
    7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .
    7,4'-Dihydroxyflavone

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