2. Apoptosis NF-κB PI3K/Akt/mTOR Metabolic Enzyme/Protease
  3. Apoptosis NF-κB Akt MMP
  4. Licoricidin

Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC50=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer. Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect. Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo. Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations.

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Licoricidin Chemical Structure

Licoricidin Chemical Structure

CAS No. : 30508-27-1

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Based on 1 publication(s) in Google Scholar

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Description

Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC50=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer[1]. Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect[1]. Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo[3]. Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations[4].

In Vitro

Licoricidin (LCD) (0-20 μM; 24 hours) dose-dependently inhibits the viability of colon cancer cell lines with various pathological and genetic characters, namely SW480, HCT116, SW620 and LoVo cells, with IC50 values of 7.2, 5.4, 4.5 and 5.1 μM, respectively[1].
Licoricidin (LCD) (0-20 μM; 0-12 hours) induces cell apoptosis was accompanied with the activation of caspase-3 by cleavage in a time- and dose-dependent manner[1].
Licoricidin (LCD) (0-20 μM; 0-12 hours) induces autophagy of SW480 cells, increases the cleavage of LC3-I to LC3-II and the degradation of p62 in a time and dose dependent manner[1].
Licoricidin (LCD) (0-5 μg/ml; 18 hours) inhibits cell migration, MMP-9 secretion, and VCAM expression in 4T1 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Licoricidin Related Antibodies

Cell Viability Assay[1]

Cell Line: SW480, HCT116, SW620 and LoVo cells
Concentration: 0-20 μM
Incubation Time: 24 hours
Result: Decreased colon cancer cell lines viability.

Western Blot Analysis[1]

Cell Line: SW480 cells
Concentration: 0 μM, 2.5 μM, 5 μM, 10 μM, 20 μM
Incubation Time: 0 hours, 1 hour, 3 hours, 6 hours, 12 hours
Result: Induced cell apoptosis.
In Vivo

Licoricidin (LCD) (intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 15 days) significantly inhibited the growth of SW480 xenografts in nude mice with an inhibitory rate of 43.5%[1].
Licoricidin (LCD) (intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 32 days) reduces pulmonary metastasis and the expression of CD45, CD31, HIF-1α, iNOS, COX-2, and VEGF-A in tumor tissues, additionally, decreases protein expression of VEGF-R2, VEGF-C, VEGF-R3, and LYVE-1 in tumor tissues of licoricidin-treated mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SW480 xenografted tumor growth in nude mice[1]
Dosage: 5, 10, or 20 mg/kg
Administration: Intraperitoneal injection; once daily; 15 days
Result: Decreased tumor volumes.
Animal Model: BALB/c mouse orthotopic model[2]
Dosage: 5, 10, or 20 mg/kg
Administration: Intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 32 days
Result: Inhibited Lung Metastasis of 4T1 Murine Mammary Carcinoma cells.
Molecular Weight

424.53

Formula

C26H32O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=C2C(OC[C@@H](C3=C(C(C/C=C(C)/C)=C(O)C=C3)O)C2)=CC(O)=C1C/C=C(C)/C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (235.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3555 mL 11.7777 mL 23.5555 mL
5 mM 0.4711 mL 2.3555 mL 4.7111 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3555 mL 11.7777 mL 23.5555 mL 58.8887 mL
5 mM 0.4711 mL 2.3555 mL 4.7111 mL 11.7777 mL
10 mM 0.2356 mL 1.1778 mL 2.3555 mL 5.8889 mL
15 mM 0.1570 mL 0.7852 mL 1.5704 mL 3.9259 mL
20 mM 0.1178 mL 0.5889 mL 1.1778 mL 2.9444 mL
25 mM 0.0942 mL 0.4711 mL 0.9422 mL 2.3555 mL
30 mM 0.0785 mL 0.3926 mL 0.7852 mL 1.9630 mL
40 mM 0.0589 mL 0.2944 mL 0.5889 mL 1.4722 mL
50 mM 0.0471 mL 0.2356 mL 0.4711 mL 1.1778 mL
60 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9815 mL
80 mM 0.0294 mL 0.1472 mL 0.2944 mL 0.7361 mL
100 mM 0.0236 mL 0.1178 mL 0.2356 mL 0.5889 mL
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Licoricidin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Licoricidin30508-27-1ApoptosisNF-κBAktMMPNuclear factor-κBNuclear factor-kappaBPKBProtein kinase BMatrix metalloproteinasesInhibitorinhibitorinhibit

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