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Cat. No.: HY-N3385

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Licorisoflavan A

Name: Licorisoflavan A
Brand: MedChemExpress
SKU: HY-N3385
Price: 485.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: 7-O-Methyllicorisoflavan B)

Licorisoflavan A (7-O-Methyllicorisoflavan B) is a isoflavan-quinone, that can be isolated from Glycyrrhiza uralensis. Licorisoflavan A exhibits anti-inflammatory and antimicrobial properties. It can inhibit the secretion of IL-6 and chemokines by LPS-stimulated macrophages in a concentration-dependent manner, and also suppress the secretion of MMP-7, MMP-8, and MMP-9 in macrophages. Licorisoflavan A exertes potent antidepressant-like effects involving BDNF-TrkB pathway and AMPA receptors.

For research use only. We do not sell to patients.

CAS No.: 129314-37-0
Formula: C₂₇H₃₄O₅
Molecular Weight:438.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (288 KB)

Licorisoflavan A Chemical Structure

CAS No.: 129314-37-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

Licorisoflavan A (7-O-Methyllicorisoflavan B) is a isoflavan-quinone, that can be isolated from Glycyrrhiza uralensis^[1]. Licorisoflavan A exhibits anti-inflammatory and antimicrobial properties^[2]^[3]. It can inhibit the secretion of IL-6 and chemokines by LPS-stimulated macrophages in a concentration-dependent manner, and also suppress the secretion of MMP-7, MMP-8, and MMP-9 in macrophages^[4]. Licorisoflavan A exertes potent antidepressant-like effects involving BDNF-TrkB pathway and AMPA receptors^[5].

IC₅₀ & Target

TrkB

MMP-7

MMP-8

MMP-9

All MMP Isoforms :

All Trk Receptor Isoforms :

Chemical Information

CAS No. 129314-37-0
Molecular Weight 438.56
Formula C₂₇H₃₄O₅
SMILES

COC1=C2C(OC[C@@H](C3=C(C(C/C=C(C)/C)=C(O)C=C3)O)C2)=CC(OC)=C1C/C=C(C)/C
Synonyms

7-O-Methyllicorisoflavan B
Structure Classification
- Flavonoids
- Other Flavonoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (288 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gafner S, et al. Isoflavonoids and coumarins from Glycyrrhiza uralensis: antibacterial activity against oral pathogens and conversion of isoflavans into isoflavan-quinones during purification. J Nat Prod. 2011 Dec 27;74(12):2514-9. [Content Brief]

[2]. Ahn SJ, Park SN, Lee YJ, Cho EJ, Lim YK, Li XM, Choi MH, Seo YW, Kook JK. In vitro antimicrobial activities of 1-methoxyficifolinol, licorisoflavan A, and 6,8-diprenylgenistein against Streptococcus mutans. Caries Res. 2015;49(1):78-89.

[3]. Villinski JR, Bergeron C, Cannistra JC, Gloer JB, Coleman CM, Ferreira D, Azelmat J, Grenier D, Gafner S. Pyrano-isoflavans from Glycyrrhiza uralensis with antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis. J Nat Prod. 2014 Mar 28;77(3):521-6.

[4]. La VD, Tanabe S, Bergeron C, Gafner S, Grenier D. Modulation of matrix metalloproteinase and cytokine production by licorice isolates licoricidin and licorisoflavan A: potential therapeutic approach for periodontitis. J Periodontol. 2011 Jan;82(1):122-8.

[5]. Xiao D, Liu L, Li Y, Ruan J, Wang H. Licorisoflavan A Exerts Antidepressant-Like Effect in Mice: Involvement of BDNF-TrkB Pathway and AMPA Receptors. Neurochem Res. 2019 Sep;44(9):2044-2056.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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