1. Metabolic Enzyme/Protease
    Anti-infection
    Autophagy
    Apoptosis
  2. Aldose Reductase
    Influenza Virus
    Autophagy
    Apoptosis
  3. Isoliquiritigenin

Isoliquiritigenin (Synonyms: GU17; ISL; Isoliquiritigen)

Cat. No.: HY-N0102 Purity: 98.24%
Handling Instructions

Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza glabra, which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM.

For research use only. We do not sell to patients.

Isoliquiritigenin Chemical Structure

Isoliquiritigenin Chemical Structure

CAS No. : 961-29-5

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Customer Review

Based on 11 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Isoliquiritigenin purchased from MCE. Usage Cited in: Open Life Sci. 2017; 12: 300–307

    Western blot assays detect apoptosis-related protein expression of Bax, Bcl-2, active caspase-3.

    Isoliquiritigenin purchased from MCE. Usage Cited in: Chemotherapy. 2018 Jun 22;63(3):155-161.

    Western blot analysis of the effect on Bcl2, Bax, and active Caspase-3 protein expression in Isoliquiritigenin (ISL) treated U2OS cells.

    Isoliquiritigenin purchased from MCE. Usage Cited in: Oncol Lett. 2018 Nov;16(5):6133-6139.

    Western blot analysis of the expression of E cadherin, N cadherin and vimentin in A549 cells following treatment with Isoliquiritigenin (ISL) for 48 h.

    Isoliquiritigenin purchased from MCE. Usage Cited in: Onco Targets Ther. 2018 Mar 22;11:1633-1642.

    Isoliquiritigenin (ILQ) treatment affects the expression level of apoptosis-related proteins.

    Isoliquiritigenin purchased from MCE. Usage Cited in: Am J Transl Res. 2018 Dec 15;10(12):4141-4151.

    The expression of CD68, CD206, iNOS, MPO is determined by immunohistochemistry in four animal groups. LPS increases the expression of CD68, iNOS and MPO but decreases the expression of CD206 in murine kidney, while ISL reduces the expression of CD68, iNOS and MPO then increases the expression of CD206 in mice kidney after LPS injection.

    Isoliquiritigenin purchased from MCE. Usage Cited in: Am J Transl Res. 2018 Dec 15;10(12):4141-4151.

    ISL inhibits phosphorylation of IκB-α following LPS stimulation. The expressions of IκB-α and p-IκB are measured by western blot. The samples are harvested from cells and mice. The results show that ISL could effectively decrease protein levels of p-IκB in HK2 of the LPS-induced mice but increase IκB-α.
    • Biological Activity

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    Description

    Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza glabra, which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM.

    IC50 & Target

    IC50: 320 nM (Aldose reductase)

    In Vitro

    Isoliquiritigenin may prevent diabetic complications through inhibiting rat lens aldose reductase with an IC50 of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 μM[1]. Isoliquiritigenin (100 μM) markedly inhibits the hypoxia-induced prolonged TPS and TR90 of cardiomyocytes. Isoliquiritigenin significantly triggers AMPK Thr172 phosphorylation as compared with vehicle group. Isoliquiritigenin treatment also induces extracellular signal-regulated kinase (ERK) signaling pathway in the cardiomyocytes. Isoliquiritigenin treatment significantly decreases the intracellular ROS levels of isolated cardiomyocytes during hypoxia/reoxygenation[3]. Isoliquiritigenin not only downregulates IL-6 expression but also significantly decreases levels of phosphorylated ERK and STAT3 and can inhibit phosphorylation levels of ERK and STAT3 induced by recombinant human IL-6, which are critical signaling proteins in IL-6 signaling regulation networks[4].

    In Vivo

    Isoliquiritigenin shows concentration-dependent inhibition of the tonic contraction of mouse jejunum induced by various types of stimulants such as CCh (1 mM), KCl (60 mM) and BaCl2 (0.3 mM) with IC50 values of 4.96±1.97 mM, 4.03±1.34 mM and 3.70±0.58 mM, respectively[2]. Isoliquiritigenin exhibits significant anti-tumor activity in MM xenograft models and synergistically enhances the anti-myeloma activity of adriamycin[4].

    Molecular Weight

    256.25

    Formula

    C₁₅H₁₂O₄

    CAS No.

    961-29-5

    SMILES

    O=C(C1=CC=C(O)C=C1O)/C=C/C2=CC=C(O)C=C2

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    Ethanol : 100 mg/mL (390.24 mM; Need ultrasonic)

    DMSO : ≥ 100 mg/mL (390.24 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.9024 mL 19.5122 mL 39.0244 mL
    5 mM 0.7805 mL 3.9024 mL 7.8049 mL
    10 mM 0.3902 mL 1.9512 mL 3.9024 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (9.76 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (9.76 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (9.76 mM); Clear solution

    • 4.

      Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (9.76 mM); Clear solution

    • 5.

      Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (9.76 mM); Clear solution

    • 6.

      Add each solvent one by one:  10% EtOH    90% corn oil

      Solubility: ≥ 2.5 mg/mL (9.76 mM); Suspended solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    IsoliquiritigeninGU17ISLIsoliquiritigenGU 17GU-17Aldose ReductaseInfluenza VirusAutophagyApoptosisInhibitorinhibitorinhibit

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    Product Name:
    Isoliquiritigenin
    Cat. No.:
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