Antiplasmodial isoflavanones from the roots of Sophora mollis

  • J Nat Prod. 2009 Jul;72(7):1265-8. doi: 10.1021/np900144c.
Gui-Ping Zhang  1 ,  Zhi-Yong Xiao ,  Jamal Rafique ,  Mohammad Arfan ,  Peter J Smith ,  Carmen A Lategan ,  Li-Hong Hu
Affiliations
  • 1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
PMID: 19572738 DOI: 10.1021/np900144c
Abstract

Six new prenylated Isoflavanones named sophoronols A-F (1-6), together with eight phenolic constituents, were isolated from the roots of Sophora mollis. Their structures and stereochemistry were established by 1D and 2D NMR techniques, especially HMBC and NOESY as well as CD results. Componds 3 and 5 exhibited moderate anitplasmodial activity against the CQS D10 strain of Plasmodium falciparum, with IC(50) values of 12.9 and 12.8 microM, respectively.