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Results for "

MAPK1

" in MedChemExpress (MCE) Product Catalog:

20

Inhibitors & Agonists

3

Peptides

5

Natural
Products

3

Recombinant Proteins

19

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13285
    Ki16425
    Maximum Cited Publications
    11 Publications Verification

    Debio 0719

    LPL Receptor YAP Neurological Disease Cancer
    Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with Kis of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA-induced activation of p42/p44 MAPK . Ki16425 can also inhibit LPA-induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells .
    Ki16425
  • HY-136848

    MAP3K Src FGFR Ribosomal S6 Kinase (RSK) LIM Kinase (LIMK) Cancer
    SM1-71 (compound 5) is a potent TAK1 inhibitor, with a Ki of 160 nM, it also can covalently inhibit MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines [1] .
    SM1-71
  • HY-N2484
    Methylnissolin
    2 Publications Verification

    Astrapterocarpan

    PDGFR ERK Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
    Methylnissolin (Astrapterocarpan) is an osteoclast inhibitor with anti-inflammatory, neuroprotective and antioxidant activities. Methylnissolin downregulates the activation of the MAPK and PI3K/AKT pathways, inhibits the phosphorylation of MAPK1 and AKT1, and blocks PDGF-BB-induced phosphorylation of ERK1/2. Methylnissolin reduces the expression and secretion of proinflammatory mediators, decreases intracellular ROS levels, upregulates antioxidant enzymes, and downregulates osteoclastogenesis markers. Methylnissolin is applicable to research related to ischemic stroke, osteoporosis, cardiovascular diseases, skin aging, etc. [1]
    Methylnissolin
  • HY-113788

    Pyk2 p38 MAPK Amyloid-β Neurological Disease Inflammation/Immunology
    PF-719 is a highly selective Pyk2 inhibitor with an IC50 value of 17 nM. PF-719 promotes the activation of LKB1 and p38 MAPK. PF-719 blocks synaptic deficits induced by Amyloid-beta oligomers and reverses the inhibition of long-term potentiation induced by β-amyloid oligomers. PF-719 can be used in research related to Alzheimer's disease and autoimmune diseases [1] .
    PF-719
  • HY-N0363
    (+)-Columbianetin
    2 Publications Verification

    (S)-Columbianetin

    ERK JNK Collagen TGF-beta/Smad p38 MAPK Reactive Oxygen Species (ROS) Others
    (+)-Columbianetin ((S)-Columbianetin) acts as an inhibitor of JNK/ERK. (+)-Columbianetin inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G1 cell cycle arrest. (+)-Columbianetin is applicable to research related to skin aging [1] .
    (+)-Columbianetin
  • HY-P2456
    MBP MAPK Substrate
    2 Publications Verification

    p38 MAPK Others
    MBP MAPK Substrate is used as an exogenous substrate for MAPK .
    MBP MAPK Substrate
  • HY-N12726

    p38 MAPK MMP Infection Inflammation/Immunology Cancer
    Halociline, a derivative of alkaloids, that can be isolated from the marine fungus Penicillium griseofulvum. Halociline targets MAPK1, MMP-9, and PIK3CA in gastric cancer cells, potentially mediated by diverse pathways including cancer, lipid metabolism, atherosclerosis, and EGFR tyrosine kinase inhibitor resistance. Halociline possesses antimicrobial, antioxidant and biofilm inhibitory activities [1] .
    Halociline
  • HY-RS08092

    Small Interfering RNA (siRNA) Others

    MAPK1 Human Pre-designed siRNA Set A contains three designed siRNAs for MAPK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MAPK1 Human Pre-designed siRNA Set A
    MAPK1 Human Pre-designed siRNA Set A
  • HY-RS08093

    Small Interfering RNA (siRNA) Others

    Mapk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mapk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Mapk1 Mouse Pre-designed siRNA Set A
    Mapk1 Mouse Pre-designed siRNA Set A
  • HY-RS08094

    Small Interfering RNA (siRNA) Others

    Mapk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mapk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Mapk1 Rat Pre-designed siRNA Set A
    Mapk1 Rat Pre-designed siRNA Set A
  • HY-E70844

    MEK Cancer
    MAP2K2 (MEK2) is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. MAP2K2 phosphorylates and thus activates MAPK1/ERK2 and MAPK3/ERK1. MAP2K2 Recombinant Human Active Protein Kinase is a recombinant MAP2K2 protein that can be used to study MAP2K2-related functions [1].
    MAP2K2 Recombinant Human Active Protein Kinase
  • HY-P0141

    Akt Others
    Akt/SKG Substrate Peptide is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1 [1].
    Akt/SKG Substrate Peptide
  • HY-P0141A

    Akt Others
    Akt/SKG Substrate Peptide TFA is a synthetic peptide suitable as a substrate for Akt/PKB, which is not phosphorylated by p70S6K or MAPK1 [1].
    Akt/SKG Substrate Peptide TFA
  • HY-N17458

    Akt p38 MAPK Cancer
    N-Acetyldehydroanonaine is an alkaloid that acts as a ligand for AKT1 and MAPK1. N-Acetyldehydroanonaine can be isolated from plants of the Zanthoxylum genus. N-Acetyldehydroanonaine is applicable to the research of diseases such as gastric cancer [1] .
    N-Acetyldehydroanonaine
  • HY-RS08115

    Small Interfering RNA (siRNA) Others

    Mapk3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mapk3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Mapk3 Rat Pre-designed siRNA Set A
    Mapk3 Rat Pre-designed siRNA Set A
  • HY-N3487

    JNK p38 MAPK Inflammation/Immunology
    Isodorsmanin A is an anti-inflammatory agent. Isodorsmanin A suppresses the production of inflammatory mediators and proinflammatory cytokines. Isodorsmanin A inhibits the phosphorylation of JNK, MAPK .
    Isodorsmanin A
  • HY-152087

    ERK p38 MAPK Cardiovascular Disease
    DCZ19931 is a potent multi-targeting kinase inhibitor. DCZ19931 has anti-angiogenic effects on ocular neovascularization. DCZ19931 also inhibits ERK1/2-MAPK and p38-MAPK signaling [1].
    DCZ19931
  • HY-172787

    FGFR Akt AMPK Cancer
    FGFR4-IN-23 (compound 48c) is a FGFR4 inhibitor with an IC50 value of 2.9 nM against FGFR4 WT kinase. FGFR4-IN-23 inhibits the phosphorylation of FGFR4, AKT and MAPK .
    FGFR4-IN-23
  • HY-149921

    Src p38 MAPK Cancer
    Antiangiogenic agent 3 (compound 3) is a potent antiangiogenic agent. Antiangiogenic agent 3 is an inhibitor of human umbilical vein endothelial cells (HUVEC). Antiangiogenic agent 3 inhibits HUVEC migration and chemotactic motilities. Antiangiogenic agent 3 also decreases the gene expression of Src, cdc42, and MAPK .
    Antiangiogenic agent 3
  • HY-13285R

    Debio 0719 (Standard)

    LPL Receptor YAP Reference Standards Neurological Disease Cancer
    Ki16425 (Standard) is the analytical standard of Ki16425. This product is intended for research and analytical applications. Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with Kis of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA-induced activation of p42/p44 MAPK . Ki16425 can also inhibit LPA-induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells .
    Ki16425 (Standard)

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