Antiangiogenic agent 3
Antiangiogenic agent 3 (compound 3) is a potent antiangiogenic agent. Antiangiogenic agent 3 is an inhibitor of human umbilical vein endothelial cells (HUVEC). Antiangiogenic agent 3 inhibits HUVEC migration and chemotactic motilities. Antiangiogenic agent 3 also decreases the gene expression of Src, cdc42, and MAPK.
For research use only. We do not sell to patients.
- Formula: C19H20O7
- Molecular Weight:360.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antiangiogenic agent 3 (6.25-200 μM; 48 h) decreases cell viability of human umbilical vein endothelial cells (HUVEC)[1].
Antiangiogenic agent 3 (5 μM, 10 μM; 24 h) inhibits HUVEC migration or chemotactic motilities induced by VEGF, with 30% and 33% inhibition rate at 5 μM and 10 μM, respectively[1].
Antiangiogenic agent 3 (10 μM; 24 h) down-regulates the gene expressions of Src, cdc42, and MAPK related to the migration of epithelial cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human umbilical vein endothelial cells (HUVEC)
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Concentration:10 μM
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Incubation Time:24 hours
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Result:Decreased the expressions of VEGF and some related to epithelial cell survival, such as Akt and mTOR.
Decreased the expressions of Src, cdc42, and MAPK.
Chemical Information
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Molecular Weight 360.36
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Formula C19H20O7
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SMILES
COC1=C2C(OC(C2=C(C(O)=C1C)CO)OCCC3=CC=C(C=C3)O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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