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Cat. No.: HY-172787

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FGFR4-IN-23

FGFR4-IN-23 (compound 48c) is a FGFR4 inhibitor with an IC₅₀ value of 2.9 nM against FGFR4^WT kinase. FGFR4-IN-23 inhibits the phosphorylation of FGFR4, AKT and MAPK.

For research use only. We do not sell to patients.

Formula: C₂₉H₂₆Cl₂FN₇O₄
Molecular Weight:626.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

FGFR4-IN-23 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

FGFR4-IN-23 (compound 48c) is a FGFR4 inhibitor with an IC₅₀ value of 2.9 nM against FGFR4^WT kinase. FGFR4-IN-23 inhibits the phosphorylation of FGFR4, AKT and MAPK^[1].

All Akt Isoforms :

All AMPK Isoforms :

Chemical Information

Molecular Weight 626.47
Formula C₂₉H₂₆Cl₂FN₇O₄
SMILES

O=C(C1=C(NC(C=C)=O)C=C(N2CCN(C)CC2=O)C=C1F)NC3=NNC4=CC=C(O[C@H](C)C5=C(Cl)C=NC=C5Cl)C=C43
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Guo J, et al. Optimization of Aminoindazole derivatives as highly selective covalent inhibitors for wild-type and mutant FGFR4. Bioorg Chem. 2025 Jun 15;160:108469. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
Purity & Documentation
References

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FGFR4-IN-23

All Akt Isoforms

All AMPK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

FGFR4-IN-23 Related Classifications

HY-172787 Related Classifications