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Results for "

U251 glioblastoma

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Apoptosis (9) Autophagy (1) Cathepsin (1) Chloride Channel (2) COX (1) DNA Alkylator/Crosslinker (1) DNA-PK (1) DNA/RNA Synthesis (1) E1/E2/E3 Enzyme (1) Ephrin Receptor (2) ERK (1) FAK (1) Ferroptosis (1) Fluorescent Dye (3) HIF/HIF Prolyl-Hydroxylase (1) Interleukin Related (2) Lipoxygenase (1) Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1) Mitochondrial Metabolism (1) Mitophagy (1) Monoamine Oxidase (1) Mps1 (1) mTOR (1) Necroptosis (1) NF-κB (1) OLIG2 (1) Opioid Receptor (1) P-glycoprotein (2) p38 MAPK (1) Parasite (1) PARP (1) PDI (1) PGE synthase (1) Phosphatase (1) PI3K (1) Pyruvate Kinase (2) Radionuclide-Drug Conjugates (RDCs) (1) Reactive Oxygen Species (ROS) (3) Reference Standards (1) TNF Receptor (1)
By Research Areas:	Cancer (24) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (8)

By Targets:

Akt (2)

Apoptosis (9)

Autophagy (1)

Cathepsin (1)

Chloride Channel (2)

COX (1)

DNA Alkylator/Crosslinker (1)

DNA-PK (1)

DNA/RNA Synthesis (1)

E1/E2/E3 Enzyme (1)

Ephrin Receptor (2)

ERK (1)

FAK (1)

Ferroptosis (1)

Fluorescent Dye (3)

HIF/HIF Prolyl-Hydroxylase (1)

Interleukin Related (2)

Lipoxygenase (1)

Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1)

Mitochondrial Metabolism (1)

Mitophagy (1)

Monoamine Oxidase (1)

Mps1 (1)

mTOR (1)

Necroptosis (1)

NF-κB (1)

OLIG2 (1)

Opioid Receptor (1)

P-glycoprotein (2)

p38 MAPK (1)

Parasite (1)

PARP (1)

PDI (1)

PGE synthase (1)

Phosphatase (1)

PI3K (1)

Pyruvate Kinase (2)

Radionuclide-Drug Conjugates (RDCs) (1)

Reactive Oxygen Species (ROS) (3)

Reference Standards (1)

TNF Receptor (1)

By Research Areas:

Cancer (24)

Infection (1)

Inflammation/Immunology (1)

Metabolic Disease (1)

Neurological Disease (8)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107643

Reversan CBLC4H10	P-glycoprotein	Cancer
Reversan (CBLC4H10) inhibits drug efflux mediated by P-glycoprotein (Pgp) and multidrug resistance protein 1 (MRP1), and exhibits oral activity. Reversan shows activity against glioblastoma multiforme and neuroblastoma models .

HY-19939S

VX-984 4 Publications Verification M9831	DNA-PK	Cancer
VX-984 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium .

HY-N2392

Kukoamine A 1 Publications Verification	Parasite Lipoxygenase Opioid Receptor Apoptosis Autophagy Reactive Oxygen Species (ROS) Interleukin Related TNF Receptor PGE synthase COX	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Kukoamine A, a spermine alkaloid, is an orally active and brain-penetrant component found in the root barks of Lycium chinense (L. chinense) Miller. Kukoamine A inhibits purified Crithidia fasciculata trypanothione reductase and soybean lipoxygenase, activates μ-opioid receptor. Kukoamine A can inhibt cancer cell proliferation, migration and invasion, cause G0/G1 phase cell cycle arrest and induce apoptosis. Kukoamine A exerts neuroprotective effect and can induce autophagy . Kukoamine A inhibits LPS (HY-D1056)-induced NO, ROS, PGE₂, TNF-α, IL-1β, IL-6 production and COX-2 activity. Kukoamine A reverses palmitic acid-induced insulin resistance, lipid accumulation, and oxidative stress via downregulation of Srebp-1c. Kukoamine A can be used for the research of cancer, infection, inflammation, metabolic and neurological disease, such as glioblastoma and Parkinson's disease .

HY-12833

AMZ30 1 Publications Verification	Phosphatase Akt ERK	Others
AMZ30 is selective protein phosphatase methylesterase-1(PME-1) inhibitor with IC₅₀s of 600 nM and 3.5 µM in human cell lysates and in HEK 293T cells, respectively. AMZ30 shows >100-fold selectivity relative to other serine hydrolases. AMZ30 reduces the demethylated form of PP2A in living cells. AMZ30 attenuates muscle cell differentiation. AMZ30 increases the resistance of U87MG and U251MG glioblastoma cells to t-BHP-induced oxidative stress. AMZ30can be used for the study of glioblastoma .

HY-P11287A

DOTA-Pep-1L TFA	Interleukin Related Radionuclide-Drug Conjugates (RDCs)	Cancer
DOTA-Pep-1L TFA is a polypeptide formed by the conjugation of DOTA and Pep-1L. DOTA-Pep-1L TFA specifically binds to IL13RA2 and can be used for the synthesis of targeted polypeptides. DOTA-Pep-1L TFA yields the isotopically labeled product [ ²²⁵Ac]DOTA-Pep-1L, which exerts α-radiation killing effects on orthotopic glioma cells and extends the median survival time of mice bearing orthotopic glioma models after stereotactic injection. DOTA-Pep-1L TFA can be used for PET imaging, tumor targeting and glioma research .

HY-131943

DS44960156	Methylenetetrahydrofolate Dehydrogenase (MTHFD)	Neurological Disease Cancer
DS44960156 is a selective MTHFD2 inhibitor with moderate to low blood-brain barrier penetration (IC₅₀=1.6 μM, K_i=1.23 μM). DS44960156 specifically binds to the active site of MTHFD2, disrupts redox homeostasis and blocks serine-mediated one-carbon metabolism, thereby increasing the NAD ⁺/NADH ratio and ROS levels. DS44960156 not only effectively inhibits the proliferation of glioma cells, but also enhances the sensitivity of cells to glutamine starvation-induced death. DS44960156 binds to plasma proteins, shows no mutagenicity, carcinogenicity or acute oral toxicity, and serves as a research agent for glioblastoma multiforme and other cancers .

HY-147637

EphA2 agonist 1	Ephrin Receptor	Cancer
EphA2 agonist 1 (Compound 7bg) is a potent EphA2 receptor agonist. EphA2 agonist 1 shows great potency and selectivity toward EphA2 overexpressed glioblastoma cells and stimulates EphA2 phosphorylation .

HY-146320

ANO1-IN-1 2 Publications Verification	Chloride Channel	Cancer
ANO1-IN-1 (Compound 9c) is a selective ANO1 channel blocker with an IC₅₀ of 2.56 μM and 15.43 μM against ANO1 and ANO2, respectively. ANO1-IN-1 suppresses strongly proliferation of glioblastoma cells .

HY-120115

PARPi-FL Olaparib-bodipy FL	PARP Fluorescent Dye	Cancer
PARPi-FL (Olaparib-bodipy FL) is a small-molecule fluorescent inhibitor of PARP1 that can specifically bind to PARP1. PARPi-FL can be used as a fluorescent imaging agent for tumor detection, diagnosis, and surgical guidance .

HY-163835

UniPR1454	Ephrin Receptor	Cancer
UniPR1454 targets EphA2 receptor, inhibits the EphA2-ephrin A1 interaction with an IC₅₀ of 2.6 μM. UniPR1454 inhibits the proliferation of glioblastoma cell U251 .

HY-175530

OLIG2-IN-1	OLIG2	Cancer
OLIG2-IN-1 is a potent and selective oligodendrocyte transcription factor 2 (OLIG2) inhibitor. OLIG2-IN-1 directly and dose-dependently downregulates nuclear OLIG2 levels with an IC₅₀ value of 0.88 μM. OLIG2-IN-1 exhibits strong anti-proliferative activity in U87 and U251 cells with IC₅₀ values of 7.02 μM and 6.43 μM, respectively. OLIG2-IN-1 can be used for the research of cancer, such as glioblastoma multiforme .

HY-155532

10m/ZS44	Apoptosis	Cancer
10m/ZS44 is a blood-brain barrier-permeable Glioblastoma (GBM) inhibitor. 10m/ZS44 significantly inhibits GBM tumor growth in a mouse xenograft model. 10m/ZS44 also activates the SIRT1/p53-mediated apoptosis pathway, thereby inhibiting the proliferation of U251 cells .

HY-P11326

Ac-FR-AFC TFA	Cathepsin Fluorescent Dye	Neurological Disease Cancer
Ac-FR-AFC TFA is a fluorometric substrate for cathepsin L. Ac-FR-AFC TFA can be used for the research of glioblastoma .

HY-168883

PKM2 modulator 2	Apoptosis Pyruvate Kinase	Cancer
PKM2 modulator 2 (compound C599) is a potent PKM2 inhibitor. PKM2 modulator 2 shows antiproliferative activity. PKM2 modulator 2 induces apoptosis. PKM2 modulator 2 has the potential for the research of glioblastoma .

HY-168899

FAK-IN-24	FAK Apoptosis	Cancer
FAK-IN-24 (Compound 9f) is a FAK inhibitor (IC₅₀: 0.815 nM). FAK-IN-24 induces DNA damage and apoptosis. FAK-IN-24 has anti-glioblastoma activity. FAK-IN-24 inhibits proliferation of glioblastoma cell lines U87-MG (IC₅₀ = 15 nM) and U251 (IC₅₀ = 20 nM). FAK-IN-24 inhibits tumor growth in U87-MG xenograft model .

HY-163290

HDAC-MB	Fluorescent Dye Monoamine Oxidase	Cancer
HDAC-MB a probe that is activated by HDAC6 and can detect and eliminate glioma cells through activation by HDAC6. HDAC-MB reveals antimetastatic and antiproliferative properties, inhibits glioma invasion and induces cellular apoptosis .

HY-12401A

Mps1-IN-3 hydrochloride 1 Publications Verification	Mps1	Cancer
Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC₅₀ value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model .

HY-168882

PKM2 modulator 1	Apoptosis Pyruvate Kinase	Cancer
PKM2 modulator 1 (compound C998) is a potent PKM2 inhibitor. PKM2 modulator 1 shows antiproliferative activity. PKM2 modulator 1 induces apoptosis. PKM2 modulator 1 has the potential for the research of glioblastoma .

HY-146321

ANO1-IN-2	Chloride Channel	Cancer
ANO1-IN-2 (Compound 10q) is a selective ANO1 channel blocker with an IC₅₀ of 1.75 μM and 7.43 μM against ANO1 and ANO2, respectively. ANO1-IN-2 suppresses strongly proliferation of glioblastoma cells .

HY-107643R

Reversan (Standard) CBLC4H10 (Standard)	Reference Standards P-glycoprotein	Cancer
Reversan (Standard) is the analytical standard of Reversan (HY-107643). This product is intended for research and analytical applications. Reversan (CBLC4H10) inhibits drug efflux mediated by P-glycoprotein (Pgp) and multidrug resistance protein 1 (MRP1), and exhibits oral activity. Reversan shows activity against glioblastoma multiforme and neuroblastoma models .

HY-181073

Apoptosis/necroptosis inducer 1	Apoptosis Necroptosis NF-κB p38 MAPK	Neurological Disease Cancer
Apoptosis/necroptosis inducer 1 is an orally active and brain-penetrant apoptosis and necroptosis inducer. Apoptosis/necroptosis inducer 1 induces mitochondria-dependent (intrinsic pathway) apoptosis. Apoptosis/necroptosis inducer 1 induces necroptosis by activating the TNF-α/NF-κB/MAPK signaling pathway. Apoptosis/necroptosis inducer 1 exhibits antiproliferative activity in glioblastoma cell lines and multiple solid tumor types. Apoptosis/necroptosis inducer 1 inhibits growth of orthotopic glioblastoma in animal models and improves survival rate. Apoptosis/necroptosis inducer 1 can be used for the research of glioblastoma .

HY-183638

T7117	E1/E2/E3 Enzyme HIF/HIF Prolyl-Hydroxylase	Neurological Disease Cancer
T7117 is a TRIM25-HIF-1α inhibitor. T7117 disrupts the interaction between TRIM25-HIF-1α. T7117 can be used for the research of glioblastoma .

HY-181982

HJ03	Ferroptosis DNA Alkylator/Crosslinker DNA/RNA Synthesis Apoptosis Reactive Oxygen Species (ROS)	Neurological Disease Cancer
HJ03 is a blood-brain barrier-permeable, orally active DNA damage and ferroptosis inducer. HJ03 triggers ferroptosis by increasing intracellular ROS, Fe ²⁺ accumulation and lipid peroxidation. HJ03 induces DNA adducts and interstrand crosslinks, blocks DNA replication and transcription, arrests cells at the G2/M phase and induces apoptosis. HJ03 can be used in the research of glioblastoma multiforme and colorectal cancer .

HY-181573

TC8026	PDI Apoptosis	Neurological Disease Cancer
TC8026 is an allosteric-covalent inhibitor targeting protein disulfide isomerase (PDI), with an IC₅₀ of 7 μM against human PDI. TC8026 induces endoplasmic reticulum stress-mediated apoptosis. TC8026 is a hit compound with PDI inhibitory activity identified via high-throughput screening, and it can be used for the research of glioblastoma .

HY-N12531

Molephantin	Reactive Oxygen Species (ROS) Mitochondrial Metabolism Mitophagy Apoptosis PI3K Akt mTOR	Neurological Disease Cancer
Molephantin is a blood-brain barrier permeable anti-glioblastoma compound. Molephantin induces ROS generation, leading to mitochondrial damage, Mitophagy flux blockage and Apoptosis induction. Molephantin can suppress the PI3K/Akt/mTOR signaling pathway. Molephantin demonstrates antitumor effects against glioblastoma .

Cat. No.	Product Name	Target	Research Area