2. Metabolic Enzyme/Protease
  3. Methylenetetrahydrofolate Dehydrogenase (MTHFD)
  4. DS44960156

DS44960156 

Cat. No.: HY-131943 Purity: 99.36%
COA Handling Instructions

DS44960156 is a selective Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor, with IC50 values of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively.

For research use only. We do not sell to patients.

DS44960156 Chemical Structure

DS44960156 Chemical Structure

CAS No. : 2361327-08-2

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 264 In-stock
Solution
10 mM * 1 mL in DMSO USD 264 In-stock
Solid
5 mg USD 240 In-stock
10 mg USD 390 In-stock
25 mg USD 840 In-stock
50 mg USD 1350 In-stock
100 mg USD 1980 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

DS44960156 is a selective Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor, with IC50 values of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively[1].

IC50 & Target

IC50: 1.6 μM (MTHFD2), >30 μM (MTHFD1)[1].
Molecular Weight

349.34

Appearance

Solid

Formula

C20H15NO5
CAS No.
SMILES

O=C(O)C1=CC=C(C(N2CCC(C3=CC=CC=C3O4)=C(C4=O)C2)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (286.25 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8625 mL 14.3127 mL 28.6254 mL
5 mM 0.5725 mL 2.8625 mL 5.7251 mL
10 mM 0.2863 mL 1.4313 mL 2.8625 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.36%

COA (248 KB) HNMR (139 KB) RP-HPLC (246 KB) LCMS (382 KB) Elemental Analysis Report (107 KB)

Handling Instructions (2659 KB)
References
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DS44960156 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DS449601562361327-08-2DS 44960156DS-44960156Methylenetetrahydrofolate Dehydrogenase (MTHFD)Inhibitorinhibitorinhibit

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