2. Cell Cycle/DNA Damage Cytoskeleton
  3. Mps1
  4. Mps1-IN-3 hydrochloride

Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model.

For research use only. We do not sell to patients.

Mps1-IN-3 hydrochloride Chemical Structure

Mps1-IN-3 hydrochloride Chemical Structure

CAS No. : 2989453-29-2

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10 mg USD 108 In-stock
25 mg USD 216 In-stock
50 mg USD 345 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Mps1-IN-3 hydrochloride:

Mps1-IN-3 hydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Mps1-IN-3 hydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model[1].

IC50 & Target

IC50: 50 nM (Mps1)[1]
In Vitro

Mps1-IN-3 hydrochloride (0.3-10 μM) inhibits the marker of mitotic cells cyclin B in a dose-dependent manner[1].
Mps1-IN-3 hydrochloride (2 μM) causes a dose-dependent escape from a checkpoint-mediated mitotic arrest[1].
Mps1-IN-3 hydrochloride (1-15 μM) inhibits the proliferation of U251 glioblastoma cells with an IC50 value of ~5 µM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mps1-IN-3 hydrochloride Related Antibodies
In Vivo

Mps1-IN-3 hydrochloride (2 mg/kg; IV, twice a week, for 3 weeks) effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

574.09

Formula

C26H32ClN7O4S
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

OC1CCN(C2=CC=C(NC3=NC(NC4=CC=CC=C4S(=O)(C(C)C)=O)=C5N=CNC5=N3)C(OC)=C2)CC1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 20 mg/mL (34.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7419 mL 8.7094 mL 17.4189 mL
5 mM 0.3484 mL 1.7419 mL 3.4838 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7419 mL 8.7094 mL 17.4189 mL 43.5472 mL
5 mM 0.3484 mL 1.7419 mL 3.4838 mL 8.7094 mL
10 mM 0.1742 mL 0.8709 mL 1.7419 mL 4.3547 mL
15 mM 0.1161 mL 0.5806 mL 1.1613 mL 2.9031 mL
20 mM 0.0871 mL 0.4355 mL 0.8709 mL 2.1774 mL
25 mM 0.0697 mL 0.3484 mL 0.6968 mL 1.7419 mL
30 mM 0.0581 mL 0.2903 mL 0.5806 mL 1.4516 mL
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Mps1-IN-3 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mps1-IN-32989453-29-2Mps1Monopolar spindle 1glioblastomacyclin Bmitotic arrestantimitoticU251VincristineInhibitorinhibitorinhibit

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