Mps1-IN-3 hydrochloride
Based on 1 publication(s) in Google Scholar
Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model.
For research use only. We do not sell to patients.
- Purity: 98.04%
- CAS No.: 2989453-29-2
- Formula: C26H32ClN7O4S
- Molecular Weight:574.09
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Mps1-IN-3 hydrochloride
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Biological Activity
IC50: 50 nM (Mps1)[1]
Mps1-IN-3 hydrochloride (0.3-10 μM) inhibits the marker of mitotic cells cyclin B in a dose-dependent manner[1].
Mps1-IN-3 hydrochloride (2 μM) causes a dose-dependent escape from a checkpoint-mediated mitotic arrest[1].
Mps1-IN-3 hydrochloride (1-15 μM) inhibits the proliferation of U251 glioblastoma cells with an IC50 value of ~5 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2989453-29-2
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Appearance Solid
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Molecular Weight 574.09
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Formula C26H32ClN7O4S
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Color Light yellow to green yellow
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SMILES
OC1CCN(C2=CC=C(NC3=NC(NC4=CC=CC=C4S(=O)(C(C)C)=O)=C5N=CNC5=N3)C(OC)=C2)CC1.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Metab
2021 Jun 1;33(6):1111-1123.e4. PMID: 33811821
Solvent & Solubility
DMSO : ≥ 20 mg/mL (34.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7419 mL | 8.7094 mL | 17.4189 mL | 43.5472 mL |
| 5 mM | 0.3484 mL | 1.7419 mL | 3.4838 mL | 8.7094 mL | |
| 10 mM | 0.1742 mL | 0.8709 mL | 1.7419 mL | 4.3547 mL | |
| 15 mM | 0.1161 mL | 0.5806 mL | 1.1613 mL | 2.9031 mL | |
| 20 mM | 0.0871 mL | 0.4355 mL | 0.8709 mL | 2.1774 mL | |
| 25 mM | 0.0697 mL | 0.3484 mL | 0.6968 mL | 1.7419 mL | |
| 30 mM | 0.0581 mL | 0.2903 mL | 0.5806 mL | 1.4516 mL |
Mps1-IN-3 hydrochloride Related Classifications
HY-12401A Related Classifications
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