10m/ZS44
10m/ZS44 is a blood-brain barrier-permeable Glioblastoma (GBM) inhibitor. 10m/ZS44 significantly inhibits GBM tumor growth in a mouse xenograft model. 10m/ZS44 also activates the SIRT1/p53-mediated apoptosis pathway, thereby inhibiting the proliferation of U251 cells.
For research use only. We do not sell to patients.
- CAS No.: 3008988-49-3
- Formula: C31H32N2O6
- Molecular Weight:528.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U-251 | IC50 |
0.9 μM
Compound: 10m; ZS44
|
Antiproliferative activity against human U-251 cells assessed as cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human U-251 cells assessed as cell viability measured after 72 hrs by MTT assay
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[PMID: 37385078] |
| U-87MG ATCC | IC50 |
2.1 μM
Compound: 10m; ZS44
|
Antiproliferative activity against human U87 cells assessed as cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human U87 cells assessed as cell viability measured after 72 hrs by MTT assay
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[PMID: 37385078] |
Chemical Information
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CAS No. 3008988-49-3
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Molecular Weight 528.60
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Formula C31H32N2O6
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SMILES
COC1=CC(C(/C=C/C2=CC=C(C=C2)C(N3CCN(C34COC4)CC5=CC=CC=C5)=O)=O)=CC(OC)=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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