2. Others Neuronal Signaling
  3. Fluorescent Dye Monoamine Oxidase
  4. HDAC-MB

HDAC-MB a probe that is activated by HDAC6 and can detect and eliminate glioma cells through activation by HDAC6. HDAC-MB reveals antimetastatic and antiproliferative properties, inhibits glioma invasion and induces cellular apoptosis.

For research use only. We do not sell to patients.

HDAC-MB

HDAC-MB Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

HDAC-MB Related Antibodies

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Description

HDAC-MB a probe that is activated by HDAC6 and can detect and eliminate glioma cells through activation by HDAC6. HDAC-MB reveals antimetastatic and antiproliferative properties, inhibits glioma invasion and induces cellular apoptosis[1].

In Vitro

HDAC-MB (10 μM) can be activated by HDAC6, produces near-infrared fluorescence and images HDAC6[1].
HDAC-MB (0-5 μM) is phototoxic and activated by HDAC6 in HeLab and U251 cells[1].
HDAC-MB (5 μM) inhibits the glioma cells migration, invasion and proliferation through the synergestic effect of MAO A inhibition and PDT, induces thereby glioma cellsapoptosis[1].Guide (The following is our recommended solution. This solution is merely a guideline and should be modified according to your specific needs.)
Typical usage scenarios include :
Target cell lines: U251 glioma cells and HeLa cells.
Concentration: 1 - 10 μM (typically 5 μM is used).
Incubation time: Approximately 24 hours (for example, U251 cells, 24 hours).
Methodology: Imaging: This probe emits near-infrared fluorescence (when excited at a concentration of 10 μM) after being activated by HDAC6.
Photodynamic therapy (PDT): HDAC-MB exhibits enhanced anti-migration and anti-proliferation effects under light exposure, reducing cell migration by up to 70%.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-MB Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HeLa
Concentration: 0-5 μM
Incubation Time: 24 h
Result: Revealed a dose-dependent cytotoxicity.

Cell Migration Assay [1]

Cell Line: U251 cells
Concentration: 1 μM
Incubation Time: 24 h
Result: Reduced the cell migration by 40% with no irradiation, reduced the cell migration by 70% with light irradiation.

Apoptosis Analysis[1]

Cell Line: U251 cells
Concentration: 15 μM
Incubation Time: 24 h
Result: Induced apoptosis upon NIR light irradiation.
Molecular Weight

590.73

Formula

C32H38N4O5S
Appearance

Solid

Color

Light blue to blue

SMILES

CC(NCCCCCC(OC1=CC=C(C=C1)COC(N2C3=CC=C(C=C3SC4=CC(N(C)C)=CC=C42)N(C)C)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

RT, protect from light

In solvent -80°C 1 year
-20°C 6 months
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (169.28 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6928 mL 8.4641 mL 16.9282 mL
5 mM 0.3386 mL 1.6928 mL 3.3856 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6928 mL 8.4641 mL 16.9282 mL 42.3205 mL
5 mM 0.3386 mL 1.6928 mL 3.3856 mL 8.4641 mL
10 mM 0.1693 mL 0.8464 mL 1.6928 mL 4.2321 mL
15 mM 0.1129 mL 0.5643 mL 1.1285 mL 2.8214 mL
20 mM 0.0846 mL 0.4232 mL 0.8464 mL 2.1160 mL
25 mM 0.0677 mL 0.3386 mL 0.6771 mL 1.6928 mL
30 mM 0.0564 mL 0.2821 mL 0.5643 mL 1.4107 mL
40 mM 0.0423 mL 0.2116 mL 0.4232 mL 1.0580 mL
50 mM 0.0339 mL 0.1693 mL 0.3386 mL 0.8464 mL
60 mM 0.0282 mL 0.1411 mL 0.2821 mL 0.7053 mL
80 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.5290 mL
100 mM 0.0169 mL 0.0846 mL 0.1693 mL 0.4232 mL
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HDAC-MB Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-MBFluorescent DyeMonoamine OxidaseMAOglioblastoma multiformeHeLa cellsU251 cellsInhibitorinhibitorinhibit

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