EphA2 agonist 1
Based on 1 Customer Validation
EphA2 agonist 1 (Compound 7bg) is a potent EphA2 receptor agonist. EphA2 agonist 1 shows great potency and selectivity toward EphA2 overexpressed glioblastoma cells and stimulates EphA2 phosphorylation.
For research use only. We do not sell to patients.
- Purity: 98.57%
- CAS No.: 2611459-57-3
- Formula: C50H58N12O12
- Molecular Weight:1019.07
-
Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Protein Tyrosine Kinase Compound Library
HY-L016
-
Anti-Cancer Compound Library
HY-L025
-
Angiogenesis-Related Compound Library
HY-L088
-
Heterocyclic Compound Library
HY-L138
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Protein Kinase Compound Library
HY-L196
-
Cell Proliferation Compound Library
HY-L201
-
High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
EphA2[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| U-251 | IC50 |
1.9 μM
Compound: 7bg
|
Antiproliferative activity against human U251 cells overexpressing EPHA2 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human U251 cells overexpressing EPHA2 assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 32828423] |
| U-251 | IC50 |
7.91 μM
Compound: 7bg
|
Antiproliferative activity against wild-type human U251 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against wild-type human U251 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 32828423] |
EphA2 agonist 1 (Compound 7bg) inhibits cell proliferation with IC50 values of 1.90 ± 0.55 μM and 7.91 ± 2.28 μM against U251 EphA2 overexpressed and U251 wild type cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2611459-57-3
-
Appearance Solid
-
Molecular Weight 1019.07
-
Formula C50H58N12O12
-
Color White to off-white
-
SMILES
COC1=C(C=C2C(N=C(N=C2N)N3CCN(CC3)C(C4=CC(NC(OCCOCCOCCOC(NC5=CC=CC(C(N6CCN(CC6)C7=NC8=CC(OC)=C(C=C8C(N)=N7)OC)=O)=C5)=O)=O)=CC=C4)=O)=C1)OC
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : ≥ 50 mg/mL (49.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (267 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9813 mL | 4.9064 mL | 9.8129 mL | 24.5322 mL |
| 5 mM | 0.1963 mL | 0.9813 mL | 1.9626 mL | 4.9064 mL | |
| 10 mM | 0.0981 mL | 0.4906 mL | 0.9813 mL | 2.4532 mL | |
| 15 mM | 0.0654 mL | 0.3271 mL | 0.6542 mL | 1.6355 mL | |
| 20 mM | 0.0491 mL | 0.2453 mL | 0.4906 mL | 1.2266 mL | |
| 25 mM | 0.0393 mL | 0.1963 mL | 0.3925 mL | 0.9813 mL | |
| 30 mM | 0.0327 mL | 0.1635 mL | 0.3271 mL | 0.8177 mL | |
| 40 mM | 0.0245 mL | 0.1227 mL | 0.2453 mL | 0.6133 mL |
Powered by Bioz