OLIG2-IN-1
Based on 1 Customer Validation
OLIG2-IN-1 is a potent and selective oligodendrocyte transcription factor 2 (OLIG2) inhibitor. OLIG2-IN-1 directly and dose-dependently downregulates nuclear OLIG2 levels with an IC50 value of 0.88 μM. OLIG2-IN-1 exhibits strong anti-proliferative activity in U87 and U251 cells with IC50 values of 7.02 μM and 6.43 μM, respectively. OLIG2-IN-1 can be used for the research of cancer, such as glioblastoma multiforme.
For research use only. We do not sell to patients.
- Purity: 98.55%
- Formula: C11H9Cl2N5O
- Molecular Weight:298.13
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-L013
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Anti-Cancer Compound Library
HY-L025
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CNS-Penetrant Compound Library
HY-L028
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Highly Selective Inhibitors Library
HY-L158
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
OLIG2-IN-1 (Compound B01) (10 μM, 12 h) exhibits the highest reduction in nuclear OLIG2 protein levels (75.87 %) in U87 cells[1].
OLIG2-IN-1 exhibits anti-proliferative activity in LN18 and C6 cells with IC50 values of 8.88 μM and 6.02 μM, respectively[1].
OLIG2-IN-1 (5 μM, 10 days) markedly suppresses colony formation in U87 cells[1].
OLIG2-IN-1 (0.02-10 μM, 12 h) dose-dependently reduces nuclear OLIG2 protein levels in U87 and U251 cells[1].
OLIG2-IN-1 protects OLIG2 from heat-induced denaturation in U87 cells and U251 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U87 and U251 cells
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Concentration:0.02, 0.04, 0.08, 0.16, 0.31, 0.62, 1.25, 2.5, 5, 7.5 and 10 μM
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Incubation Time:12 h
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Result:Reduced nuclear OLIG2 protein levels in a clear dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:U87 xenograft mice models[1]
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Dosage:50 mg/kg, companied with 39 mg/kg of Temozolomide (HY-17364)
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Administration:Intraperitoneally injection, every other day for 21 days
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Result:Had stable body weights.
Reduced tumor volumes to 44.6 % and weight to 50.0 %.
Downregulated OLIG2 expression.
Chemical Information
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Appearance Solid
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Molecular Weight 298.13
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Formula C11H9Cl2N5O
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Color White to off-white
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SMILES
NC1=NC=NC(NC(NC2=CC(Cl)=C(Cl)C=C2)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL (167.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3542 mL | 16.7712 mL | 33.5424 mL | 83.8560 mL |
| 5 mM | 0.6708 mL | 3.3542 mL | 6.7085 mL | 16.7712 mL | |
| 10 mM | 0.3354 mL | 1.6771 mL | 3.3542 mL | 8.3856 mL | |
| 15 mM | 0.2236 mL | 1.1181 mL | 2.2362 mL | 5.5904 mL | |
| 20 mM | 0.1677 mL | 0.8386 mL | 1.6771 mL | 4.1928 mL | |
| 25 mM | 0.1342 mL | 0.6708 mL | 1.3417 mL | 3.3542 mL | |
| 30 mM | 0.1118 mL | 0.5590 mL | 1.1181 mL | 2.7952 mL | |
| 40 mM | 0.0839 mL | 0.4193 mL | 0.8386 mL | 2.0964 mL | |
| 50 mM | 0.0671 mL | 0.3354 mL | 0.6708 mL | 1.6771 mL | |
| 60 mM | 0.0559 mL | 0.2795 mL | 0.5590 mL | 1.3976 mL | |
| 80 mM | 0.0419 mL | 0.2096 mL | 0.4193 mL | 1.0482 mL | |
| 100 mM | 0.0335 mL | 0.1677 mL | 0.3354 mL | 0.8386 mL |
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