2. Neuronal Signaling
  3. OLIG2
  4. OLIG2-IN-1

OLIG2-IN-1 is a potent and selective oligodendrocyte transcription factor 2 (OLIG2) inhibitor. OLIG2-IN-1 directly and dose-dependently downregulates nuclear OLIG2 levels with an IC50 value of 0.88 μM. OLIG2-IN-1 exhibits strong anti-proliferative activity in U87 and U251 cells with IC50 values of 7.02 μM and 6.43 μM, respectively. OLIG2-IN-1 can be used for the research of cancer, such as glioblastoma multiforme.

For research use only. We do not sell to patients.

OLIG2-IN-1

OLIG2-IN-1 Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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OLIG2-IN-1 Related Antibodies

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Description

OLIG2-IN-1 is a potent and selective oligodendrocyte transcription factor 2 (OLIG2) inhibitor. OLIG2-IN-1 directly and dose-dependently downregulates nuclear OLIG2 levels with an IC50 value of 0.88 μM. OLIG2-IN-1 exhibits strong anti-proliferative activity in U87 and U251 cells with IC50 values of 7.02 μM and 6.43 μM, respectively. OLIG2-IN-1 can be used for the research of cancer, such as glioblastoma multiforme[1].

In Vitro

OLIG2-IN-1 (Compound B01) (10 μM, 12 h) exhibits the highest reduction in nuclear OLIG2 protein levels (75.87 %) in U87 cells[1].
OLIG2-IN-1 exhibits anti-proliferative activity in LN18 and C6 cells with IC50 values of 8.88 μM and 6.02 μM, respectively[1].
OLIG2-IN-1 (5 μM, 10 days) markedly suppresses colony formation in U87 cells[1].
OLIG2-IN-1 (0.02-10 μM, 12 h) dose-dependently reduces nuclear OLIG2 protein levels in U87 and U251 cells[1].
OLIG2-IN-1 protects OLIG2 from heat-induced denaturation in U87 cells and U251 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OLIG2-IN-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: U87 and U251 cells
Concentration: 0.02, 0.04, 0.08, 0.16, 0.31, 0.62, 1.25, 2.5, 5, 7.5 and 10 μM
Incubation Time: 12 h
Result: Reduced nuclear OLIG2 protein levels in a clear dose-dependent manner.
In Vivo

OLIG2-IN-1 (Compound B01) (50 mg/kg, i.p., every other day for 21 days) inhibits tumor growth in combination with Temozolomide (HY-17364) in a U87 xenograft mice models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: U87 xenograft mice models[1]
Dosage: 50 mg/kg, companied with 39 mg/kg of Temozolomide (HY-17364)
Administration: Intraperitoneally injection, every other day for 21 days
Result: Had stable body weights.
Reduced tumor volumes to 44.6 % and weight to 50.0 %.
Downregulated OLIG2 expression.
Molecular Weight

298.13

Formula

C11H9Cl2N5O
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC=NC(NC(NC2=CC(Cl)=C(Cl)C=C2)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (167.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3542 mL 16.7712 mL 33.5424 mL
5 mM 0.6708 mL 3.3542 mL 6.7085 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3542 mL 16.7712 mL 33.5424 mL 83.8560 mL
5 mM 0.6708 mL 3.3542 mL 6.7085 mL 16.7712 mL
10 mM 0.3354 mL 1.6771 mL 3.3542 mL 8.3856 mL
15 mM 0.2236 mL 1.1181 mL 2.2362 mL 5.5904 mL
20 mM 0.1677 mL 0.8386 mL 1.6771 mL 4.1928 mL
25 mM 0.1342 mL 0.6708 mL 1.3417 mL 3.3542 mL
30 mM 0.1118 mL 0.5590 mL 1.1181 mL 2.7952 mL
40 mM 0.0839 mL 0.4193 mL 0.8386 mL 2.0964 mL
50 mM 0.0671 mL 0.3354 mL 0.6708 mL 1.6771 mL
60 mM 0.0559 mL 0.2795 mL 0.5590 mL 1.3976 mL
80 mM 0.0419 mL 0.2096 mL 0.4193 mL 1.0482 mL
100 mM 0.0335 mL 0.1677 mL 0.3354 mL 0.8386 mL
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OLIG2-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OLIG2-IN-1OLIG2Oligodendrocyte Transcription Factor 2Oligodendrocyte transcription factorU87U251Glioblastoma multiformeInhibitorinhibitorinhibit

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