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inactive metabolite

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Metabolite (29) Endogenous Metabolite (14) Aldose Reductase (1) Amyloid-β (1) Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (2) Autophagy (1) Bacterial (3) Biochemical Assay Reagents (3) c-Met/HGFR (1) COMT (1) COX (2) Cytochrome P450 (2) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (1) Drug Derivative (1) Drug Intermediate (1) Endothelin Receptor (1) GABA Receptor (1) Glucocorticoid Receptor (7) Herbicide (1) HIV (1) Isotope-Labeled Compounds (14) mAChR (2) Parasite (1) PI4K (1) Prostaglandin Receptor (1) Reactive Oxygen Species (ROS) (4) Reference Standards (8)
By Research Areas:	Cancer (14) Cardiovascular Disease (5) Endocrinology (10) Infection (9) Inflammation/Immunology (12) Metabolic Disease (6) Neurological Disease (9)

By Targets:

Drug Metabolite (29)

Endogenous Metabolite (14)

Aldose Reductase (1)

Amyloid-β (1)

Androgen Receptor (1)

Angiotensin-converting Enzyme (ACE) (1)

Apoptosis (2)

Autophagy (1)

Bacterial (3)

Biochemical Assay Reagents (3)

c-Met/HGFR (1)

COMT (1)

COX (2)

Cytochrome P450 (2)

DNA Alkylator/Crosslinker (2)

DNA/RNA Synthesis (1)

Drug Derivative (1)

Drug Intermediate (1)

Endothelin Receptor (1)

GABA Receptor (1)

Glucocorticoid Receptor (7)

Herbicide (1)

HIV (1)

Isotope-Labeled Compounds (14)

mAChR (2)

Parasite (1)

PI4K (1)

Prostaglandin Receptor (1)

Reactive Oxygen Species (ROS) (4)

Reference Standards (8)

By Research Areas:

Cancer (14)

Cardiovascular Disease (5)

Endocrinology (10)

Infection (9)

Inflammation/Immunology (12)

Metabolic Disease (6)

Neurological Disease (9)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Metabolite Endogenous Metabolite

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-126373

SN-38 glucuronide SN-38G	Drug Metabolite	Cancer
SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .

HY-13609

Deflazacort	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Deflazacort, a glucocorticoid, is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant .

HY-70002B

Enzalutamide carboxylic acid 2 Publications Verification MDV3100 carboxylic acid	Drug Metabolite	Cancer
Enzalutamide carboxylic acid (MDV3100 carboxylic acid) is an inactive metabolite of Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist .

HY-113083

Acetaminophen glucuronide APAP-glu	Drug Metabolite Endogenous Metabolite	Others
Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-N0929

Hexahydrocurcumin	COX Reactive Oxygen Species (ROS)	Cancer
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-107858

Veratryl alcohol 1 Publications Verification 3,4-Dimethoxybenzyl alcohol	Endogenous Metabolite Bacterial	Infection
Veratryl alcohol (3,4-Dimethoxybenzyl alcohol) is a secondary metabolite of lignin-degrading fungi, commonly used as a substrate for lignin peroxidase (LiP) to measure lignin degradation activity. Veratryl alcohol protects LiP from inactivation by H₂O₂ and prevents the accumulation of LiP III compounds. Veratryl alcohol also acts as a stabilizer for manganese-dependent peroxidases (MnP). Veratryl alcohol is a quorum-sensing inhibitor (QSI) and exhibits antibacterial efficacy .

HY-113257

Dopamine 4-sulfate DA-4S; Dopamine 4-Sulfate	Drug Metabolite	Neurological Disease
Dopamine 4-sulfate (DA-4S) is an inactive metabolite of the catecholamine dopamine. It is formed from dopamine by the sulfotransferase (SULT) isoform SULT1A3. Dopamine 4-O-sulfate is found at lower levels in the brain and circulation than dopamine 3-O-sulfate.

HY-113331

Thromboxane B2 1 Publications Verification	Prostaglandin Receptor	Cardiovascular Disease Inflammation/Immunology
Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation. Thromboxane B2 is a biological inactive product and circulating catabolite of thromboxane A2. Thromboxane B2 levels in peripheral venous blood and coronary sinus blood can be used as a diagnostic marker for angina. Thromboxane B2 level in serum is also associated with inhibition of COX-1 activity inhibition in platelets. Thromboxane B2 is a major product of prostaglandin endoperoxide metabolism. Thromboxane B2 produces dose-related decreases in airflow rate, tidal volume and dynamic lung compliance, whilst simultaneously increasing pulmonary airway resistance in dog model. Thromboxane B2 appears to be a naturally occurring bronchoactive metabolite in the bioconversion of arachidonic acid .

HY-120980

Thromboxane B1 TXB1	Endogenous Metabolite	Cardiovascular Disease
Thromboxane B1 (TXB1) is a stable, inactive endogenous metabolite of Thromboxane A1 (TXA1) .

HY-13633

Exisulind 2 Publications Verification	Aldose Reductase	Metabolic Disease Cancer
Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac . Exisulind inhibits aldose reductase with an IC₅₀ of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications .

HY-103638S

3-Methoxytyramine-d4 hydrochloride 1 Publications Verification 3-O-methyl Dopamine-d4 hydrochloride	Drug Metabolite Endogenous Metabolite	Neurological Disease
3-Methoxytyramine-d₄ (hydrochloride) is the deuterium labeled 3-Methoxytyramine hydrochloride. 3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1) .

HY-141749B

Clopidogrel carboxylic acid hydrochloride 1 Publications Verification CLPM hydrochloride; SR 26334 hydrochloride	Drug Metabolite	Cardiovascular Disease
Clopidogrel carboxylic acid (CLPM) hydrochloride is an inactive metabolite of the widely used antiplatelet medication clopidogrel, which serves as a reference standard for quantitative analysis of clopidogrel metabolism. Clopidogrel carboxylic acid hydrochloride has been shown to represent approximately 85% of circulating clopidogrel, hydrolyzed from the active form by esterases. Clopidogrel carboxylic acid hydrochloride plays a crucial role in assessing the pharmacokinetics and bioavailability of clopidogrel in various clinical and research settings.

HY-156685

EDI048	PI4K Parasite	Infection Metabolic Disease Cancer
EDI048 is an orally active, gut-restricted parasiticidal agent. EDI048 specifically binds to the ATP-binding site of Cryptosporidium phosphatidylinositol 4-kinase (CpPI (4) K), blocks parasite membrane biogenesis, arrests the pathogen at the schizont stage, and thus irreversibly clears the infection. EDI048 is rapidly converted to an inactive carboxylic acid metabolite via hepatic first-pass metabolism, with extremely low systemic exposure, good safety profile, and no cardiotoxicity, genotoxicity or off-target effects. EDI048 is used in studies of intestinal cryptosporidiosis in children .

HY-141749A

Clopidogrel carboxylic acid CLPM; SR 26334	Endogenous Metabolite	Metabolic Disease
Clopidogrel carboxylic acid (CLPM) is the inactive liver metabolite of anti platelet agent, Clopidogrel (HY-15283), in human serum .

HY-100085

21-Desacetyldeflazacort 21-desDFZ	Drug Metabolite	Inflammation/Immunology
21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration .

HY-151239

ONT-993 AR 00440993	Cytochrome P450	Cancer
ONT-993 is an aliphatic hydroxylated metabolite. ONT-993 inhibits CYP2D6 (IC₅₀=7.9 µM) and causes metabolism-dependent inactivation of CYP3A (KI=1.6 µM) .

HY-136913

(Rac)-Rhododendrol (Rac)-Betuligenol	Endogenous Metabolite	Inflammation/Immunology
(Rac)-Rhododendrol ((Rac)-Betuligenol) is an aromatic compound with pro-oxidant activity. (Rac)-Rhododendrol may be useful in the suppression of liver diseases. (Rac)-Rhododendrol can be toxic to melanocytes, leading to cell death. The metabolite of (Rac)-Rhododendrol, RD-quinone, is cytotoxic and causes enzyme inactivation and endoplasmic reticulum stress by binding to thiol proteins. (Rac)-Rhododendrol-derived melanin exhibits potent pro-oxidant activity and may cause oxidative stress .

HY-W587524

Carboxyphosphamide	DNA Alkylator/Crosslinker	Cancer
Carboxyphosphamide is an inactive metabolite of the alkylating agent Cyclophosphamide (HY-17420) .

HY-103638R

3-Methoxytyramine hydrochloride (Standard) 3-O-methyl Dopamine hydrochloride (Standard)	Reference Standards Drug Metabolite Endogenous Metabolite	Neurological Disease
3-Methoxytyramine (hydrochloride) (Standard) is the analytical standard of 3-Methoxytyramine (hydrochloride). This product is intended for research and analytical applications. 3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1).

HY-113164

Vitamin K1 2,3-epoxide	Endogenous Metabolite	Others
Vitamin K1 2,3-epoxide is an inactive metabolite form of Vitamin K1 (HY-N0684), which is reduced to active vitamin by microsomal epoxide reductase in the vitamin K epoxide cycle. Vitamin K1 2,3-epoxide is involved in blood clotting .

HY-126373S1

SN-38 glucuronide-13C6 SN-38G-¹³C₆	Isotope-Labeled Compounds	Others
SN-38 glucuronide- ¹³C₆ is the ¹³C labeled SN-38 glucuronide (HY-126373) . SN-38 glucuronide is an inactive metabolite of the cancer agent Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .

HY-126619

Aspochalasin D	Bacterial Apoptosis	Infection
Aspochalasin D is a co-metabolite originally isolated from A. microcysticus with aspochalasins A, B, and C, that is initially thought to be inactive. It has antibacterial activity against Gram-positive and Gram-negative bacteria at a concentration of 1 mg/ml.2 Aspochalasin D is more cytotoxic, via apoptosis, to Ba/F3-V12 cells in an IL-3-free medium than in an IL-3-containing medium (IC₅₀s=0.49 and 1.9 μg/mL, respectively).

HY-W059917

AP24600	Drug Metabolite	Others
AP24600 is an inactive metabolite of Ponatinib .

HY-N0929R

Hexahydrocurcumin (Standard)	Reference Standards COX Reactive Oxygen Species (ROS)	Cancer
Hexahydrocurcumin (Standard) is the analytical standard of Hexahydrocurcumin. This product is intended for research and analytical applications. Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-137555

11-dehydro-2,3-dinor Thromboxane B2 11-dehydro-2,3-dinor TXB2	Endogenous Metabolite	Metabolic Disease
11-dehydro-2,3-dinor Thromboxane B2 (11-dehydro-2,3-dinor TXB2) is a metabolite of the TXA2 inactive metabolite TXB2 (Item No. 19030). It is formed from TXB2 by cytosolic aldehyde dehydrogenase (ALDH) and β-oxidation. Levels of 11-dehydro-2,3-dinor TXB2 are increased 5.2-fold in a surgery-induced rat model of tendon overuse.

HY-W704031

Prasugrel metabolite 1	Drug Metabolite	Metabolic Disease
Prasugrel metabolite 1 (M7 (R-119251)) is one of the inactive metabolites of Prasugrel (HY-15284) in the human body .

HY-135500

ACT-373898	Endothelin Receptor	Endocrinology
ACT-373898 is an inactive carboxylic acid metabolite of Macitentan. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist .

HY-Z4483

6-Deoxypenciclovir	Drug Intermediate	Others
6-Deoxypenciclovir is an inactive metabolite of the antiviral prodrug Famciclovir. 6-Deoxypenciclovir is a good substrate for rabbit hepatic aldehyde oxidase and can be used to synthesize the prodrug form of penciclovir .

HY-13609S

Deflazacort-d5	Isotope-Labeled Compounds Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Deflazacort-d₅ is the deuterium labeled Deflazacort. Deflazacort, a glucocorticoid, is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant .

HY-134520

21-Deacetoxy deflazacort	Glucocorticoid Receptor	Inflammation/Immunology
21-Deacetoxy deflazacort is a dehydrogenated derivative of Deflazacort (HY-13609), a glucocorticoid, an inactive precursor that is rapidly converted to the active metabolite 21-Desacetyldeflazacort. Deflazacort acts as an anti-inflammatory and immunosuppressant .

HY-135580A

Raloxifene Bismethyl Ether hydrochloride	Drug Metabolite	Endocrinology
Raloxifene Bismethyl Ether hydrochloride is a metabolite of Raloxifene and an estrogen receptor inactive compound on which both hydroxyl groups are absent .

HY-135580

Raloxifene Bismethyl Ether	Drug Metabolite	Endocrinology
Raloxifene Bismethyl Ether is a metabolite of Raloxifene and an estrogen receptor inactive compound on which both hydroxyl groups are absent .

HY-70002BS

Enzalutamide carboxylic acid-d6 MDV3100 carboxylic acid-d₆	Autophagy Androgen Receptor Isotope-Labeled Compounds	Cancer
Enzalutamide carboxylic acid-d₆ is the deuterium labeled Enzalutamide carboxylic acid (MDV3100 carboxylic acid). Enzalutamide carboxylic acid is an inactive metabolite of Enzalutamide .

HY-137117

15-keto-PGE1 15-keto Prostaglandin E1	Drug Metabolite	Others
15-keto-PGE1 is an inactive Prostaglandin E1 (PGE1) metabolite. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation .

HY-135410

ABZ-amine Amino albendazole	Drug Metabolite	Infection
ABZ-amine (Amino albendazole) is an impurity of Albendazole. Albendazole is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations .

HY-135410R

ABZ-amine (Standard) Amino albendazole (Standard)	Drug Metabolite Reference Standards	Infection
ABZ-amine (Standard) is the analytical standard of ABZ-amine. This product is intended for research and analytical applications. ABZ-amine (Amino albendazole) is an impurity of Albendazole. Albendazole is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations .

HY-U00199

Norzopiclone N-Desmethyl zopiclone; RP 32273	Drug Metabolite	Neurological Disease
Norzopiclone is the inactive metabolite of Zopiclone. Norzopiclone has some anxiolytic properties.

HY-125074

PNU 142300	Drug Metabolite	Infection
PNU 142300 is an inactive metabolite of the oxazolidinone antibiotic Linezolid (HY-10394).

HY-W740674

4-Ketocyclophosphamide	DNA Alkylator/Crosslinker	Cancer
4-Ketocyclophosphamide is an inactive metabolite of the alkylating agent Cyclophosphamide (HY-17420).

HY-118247

Ro 14-6113	Drug Metabolite	Others
Ro 14-6113 is an inactive phenolic metabolite of the "carotenoid" Ro 15-0778, a form of vitamin A.

HY-W585982

Bisphenol A-β-D-glucuronide	Biochemical Assay Reagents	Endocrinology
Bisphenol A-β-D-glucuronide is an inactive metabolite of the plasticizer Bisphenol A (HY-18260) .

HY-132186

Abacavir carboxylate	HIV	Infection
Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor Abacavir (HY-17423) .

HY-139428

Hydroxydehydro Nifedipine Carboxylate	Drug Metabolite	Others
Hydroxydehydro Nifedipine Carboxylate is an inactive metabolite formed by the oxidative biotransformation of Nifedipine (HY-B0284) in the human body .

HY-W700319

(Rac)-5-Carboxy tolterodine	mAChR	Neurological Disease
(Rac)-5-Carboxy tolterodine is an inactive metabolite of the muscarinic acetylcholine receptor antagonist Tolterodine (HY-A0024).

HY-U00199S

N-Desmethyl zopiclone-d8	Isotope-Labeled Compounds Drug Metabolite	Neurological Disease
N-Desmethyl zopiclone-d₈ is deuterium labeled Norzopiclone. Norzopiclone is the inactive metabolite of Zopiclone. Norzopiclone has some anxiolytic properties.

HY-W700174

3-(4-Chlorophenyl)-4-hydroxybutyric acid sodium	GABA Receptor	Neurological Disease
3-(4-Chlorophenyl)-4-hydroxybutyric acid sodium is an inactive metabolite of the GABAB receptor agonist Baclofen (HY-B0007) .

HY-130318

Quinidine N-oxide	Drug Metabolite Cytochrome P450	Others
Quinidine N-oxide is a pharmacologically inactive metabolite of Quinidine (HY-B1751H). Quinidine is an active probe of CYP3A4 .

HY-43421

Solifenacin N-oxide Solifenacin N1-oxide	mAChR	Neurological Disease
Solifenacin N-oxide (Solifenacin N1-oxide) is an inactive metabolite of the muscarinic receptor antagonist Solifenacin (HY-A0034) .

HY-Z12431

Silodosin carboxylic acid impurity KMD-3293	Endogenous Metabolite	Metabolic Disease
Silodosin carboxylic acid impurity (KMD-3293) is an inactive silodosin metabolite. Silodosin carboxylic acid impurity is the major metabolite that can be generated via oxidation by alcohol and aldehyde dehydrogenase. Silodosin carboxylic acid impurity can be studied in research for benign prostatic hyperplasia .

HY-W654397

Deflazacort-d3	Isotope-Labeled Compounds	Others
Deflazacort-d3 is a isotope of Deflazacort. Deflazacort is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant .

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-113083

Acetaminophen glucuronide APAP-glu	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite Endogenous Metabolite
Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-N0929

Hexahydrocurcumin	Classification of Application Fields Phenols Polyphenols Plants Curcuma longa Disease Research Fields Source Classification Zingiberaceae Cancer	COX Reactive Oxygen Species (ROS)
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-107858

Veratryl alcohol 1 Publications Verification 3,4-Dimethoxybenzyl alcohol	Productos naturales Microorganisms Classification of Application Fields Other Diseases Disease Research Fields	Endogenous Metabolite Bacterial
Veratryl alcohol (3,4-Dimethoxybenzyl alcohol) is a secondary metabolite of lignin-degrading fungi, commonly used as a substrate for lignin peroxidase (LiP) to measure lignin degradation activity. Veratryl alcohol protects LiP from inactivation by H₂O₂ and prevents the accumulation of LiP III compounds. Veratryl alcohol also acts as a stabilizer for manganese-dependent peroxidases (MnP). Veratryl alcohol is a quorum-sensing inhibitor (QSI) and exhibits antibacterial efficacy .

HY-103638R

3-Methoxytyramine hydrochloride (Standard) 3-O-methyl Dopamine hydrochloride (Standard)	Structural Classification Monophenols Phenols Endogenous metabolite Source Classification	Reference Standards Drug Metabolite Endogenous Metabolite
3-Methoxytyramine (hydrochloride) (Standard) is the analytical standard of 3-Methoxytyramine (hydrochloride). This product is intended for research and analytical applications. 3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1).

HY-N0929R

Hexahydrocurcumin (Standard)	Structural Classification Phenols Polyphenols Plants Curcuma longa Source Classification Zingiberaceae	Reference Standards COX Reactive Oxygen Species (ROS)
Hexahydrocurcumin (Standard) is the analytical standard of Hexahydrocurcumin. This product is intended for research and analytical applications. Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-113083R

Acetaminophen glucuronide (Standard) APAP-glu (Standard)	Structural Classification Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Reference Standards Drug Metabolite Endogenous Metabolite
Acetaminophen glucuronide (Standard) is the analytical standard of Acetaminophen glucuronide. This product is intended for research and analytical applications. Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-126194

Tolcapone 3-β-D-glucuronide Ro 61-1448	Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Source Classification	Drug Metabolite COMT Amyloid-β Apoptosis Reactive Oxygen Species (ROS)
Tolcapone 3-β-D-glucuronide (Ro 61-1448) is an O-methyl metabolite of Tolcapone (HY-17406) and is pharmacologically inactive. Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC₅₀of 773 nM. Tolcapone can inhibits α-syn and Aβ₄₂ oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma .

Cat. No.	Nombre del producto	Chemical Structure

HY-103638S

3-Methoxytyramine-d4 hydrochloride 1 Publications Verification
3-Methoxytyramine-d₄ (hydrochloride) is the deuterium labeled 3-Methoxytyramine hydrochloride. 3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1) .

HY-126373S1

SN-38 glucuronide-13C6
SN-38 glucuronide- ¹³C₆ is the ¹³C labeled SN-38 glucuronide (HY-126373) . SN-38 glucuronide is an inactive metabolite of the cancer agent Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .

HY-13609S

Deflazacort-d5
Deflazacort-d₅ is the deuterium labeled Deflazacort. Deflazacort, a glucocorticoid, is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant .

HY-70002BS

Enzalutamide carboxylic acid-d6
Enzalutamide carboxylic acid-d₆ is the deuterium labeled Enzalutamide carboxylic acid (MDV3100 carboxylic acid). Enzalutamide carboxylic acid is an inactive metabolite of Enzalutamide .

HY-U00199S

N-Desmethyl zopiclone-d8
N-Desmethyl zopiclone-d₈ is deuterium labeled Norzopiclone. Norzopiclone is the inactive metabolite of Zopiclone. Norzopiclone has some anxiolytic properties.

HY-W654397

Deflazacort-d3
Deflazacort-d3 is a isotope of Deflazacort. Deflazacort is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant .

HY-13609S1

Deflazacort-d7
Deflazacort-d₇ is the deuterium labeled Deflazacort. Deflazacort, a glucocorticoid, is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant .

HY-13609S3

Deflazacort-d3-1
Deflazacort-d₃-1 is the deuterium labeled Deflazacort (HY-13609). Deflazacort, a glucocorticoid, is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant .

HY-W777677

Bisphenol b-D-glucuronide A-d6
Bisphenol b-D-glucuronide A-d₆ is the deuterium labeled Bisphenol A-β-D-glucuronide (HY-W585982). Bisphenol A-β-D-glucuronide is an inactive metabolite of the plasticizer Bisphenol A (HY-18260) .

HY-141749AS

Clopidogrel carboxylic acid-d4
Clopidogrel carboxylic acid-d₄ is a deuterated derivative of Clopidogrel carboxylic acid, which is an inactive metabolite of the antiplatelet agent Clopidogrel (HY-15283) in plasma. Clopidogrel carboxylic acid-d₄ can be used to further explore the metabolic characteristics of Clopidogrel .

HY-W585982S

Bisphenol A β-D-Glucuronide-13C12
Bisphenol A β-D-Glucuronide- ¹³C₁₂ is the ¹³C labeled isotope of Bisphenol A β-D-Glucuronide (HY-W585982). Bisphenol A-β-D-glucuronide is an inactive metabolite of the plasticizer Bisphenol A (HY-18260) .

HY-50683S

JNJ-38877605-d1
JNJ-38877605-d1 (compound DO-2) is a highly selective MNNG HOS transforming (MET) inhibitor. JNJ-38877605-d1 is thought to diminish the formation of the Aldehyde Oxidase 1 inactive metabolite M3 .

HY-W759719

21-Desacetyldeflazacort-d4

21-Desacetyldeflazacort-d₄ (21-desDFZ-d₄) is the deuterium labeled 21-Desacetyldeflazacort (HY-100085). 21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration .

HY-W704807

3-Methoxytyramine-d3 hydrochloride
3-Methoxytyramine-d₃ hydrochloride (3-O-methyl Dopamine-d₃ hydrochloride) is the deuterium labeled 3-Methoxytyramine hydrochloride (HY-103638). 3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1).

HY-W745860

Hexahydrocurcumin-d6
Hexahydrocurcumin-d₆ is the deuterium labeled Hexahydrocurcumin (HY-N0929). Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-W653919

SN-38 glucuronide-d3
SN-38 glucuronide-d₃ is deuterium labeled SN-38 glucuronide. SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .

HY-W738271

Veratryl alcohol-13C

Veratryl alcohol- ¹³C (3,4-Dimethoxybenzyl alcohol- ¹³C) is the ¹³C-labeled Veratryl alcohol (HY-107858). Veratryl alcohol (3,4-Dimethoxybenzyl alcohol) is a secondary metabolite of lignin-degrading fungi, commonly used as a substrate for lignin peroxidase (LiP) to measure lignin degradation activity. Veratryl alcohol protects LiP from inactivation by H2O2 and prevents the accumulation of LiP III compounds. Veratryl alcohol also acts as a stabilizer for manganese-dependent peroxidases (MnP). Veratryl alcohol is a quorum-sensing inhibitor (QSI) and exhibits antibacterial efficacy .

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MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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