N-Desmethyl zopiclone-d8
Based on 1 publication(s) in Google Scholar
N-Desmethyl zopiclone-d8 is deuterium labeled Norzopiclone. Norzopiclone is the inactive metabolite of Zopiclone. Norzopiclone has some anxiolytic properties.
For research use only. We do not sell to patients.
- CAS No.: 1189805-43-3
- Formula: C16H7D8ClN6O3
- Molecular Weight:382.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) N-Desmethyl zopiclone-d8
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1189805-43-3
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Unlabeled Cas 59878-63-6
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Molecular Weight 382.83
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Formula C16H7D8ClN6O3
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SMILES
O=C(N1C([2H])([2H])C([2H])([2H])NC([2H])([2H])C1([2H])[2H])OC2N(C3=NC=C(Cl)C=C3)C(C4=NC=CN=C42)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Headache Pain
Increased TSPO alleviates neuropathic pain by preventing pyroptosis via the AMPK-PGC-1α pathway. [Abstract]2025 Jan 27;26(1):16. PMID: 39871133
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Sha Y, et al. Synthesis of RP 48497, an impurity of eszopiclone. Molecules. 2008 Aug 22;13(8):1817-21. [Content Brief]
[3]. Thomas P. Jerussi, et al. Methods of making and using N-desmethylzopiclone. US 6339086 B1.
[4]. Tornio A, et al. The CYP2C8 inhibitor gemfibrozil does not increase the plasma concentrations of zopiclone. Eur J Clin Pharmacol. 2006 Aug;62(8):645-51. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N-Desmethyl zopiclone-d8 Related Classifications
HY-U00199S Related Classifications
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