N-Desmethyl zopiclone-d8
Based on 1 publication(s) in Google Scholar
N-Desmethyl zopiclone-d8 is deuterium labeled Norzopiclone. Norzopiclone is the inactive metabolite of Zopiclone. Norzopiclone has some anxiolytic properties.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1189805-43-3
- Formel: C16H7D8ClN6O3
- Molecular Weight:382.83
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) N-Desmethyl zopiclone-d8
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Biologische Aktivität
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 1189805-43-3
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Unlabeled Cas 59878-63-6
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Molecular Weight 382.83
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Formel C16H7D8ClN6O3
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SMILES
O=C(N1C([2H])([2H])C([2H])([2H])NC([2H])([2H])C1([2H])[2H])OC2N(C3=NC=C(Cl)C=C3)C(C4=NC=CN=C42)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Headache Pain
Increased TSPO alleviates neuropathic pain by preventing pyroptosis via the AMPK-PGC-1α pathway. [Abstract]2025 Jan 27;26(1):16. PMID: 39871133
Reinheit & Dokumentation
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Sha Y, et al. Synthesis of RP 48497, an impurity of eszopiclone. Molecules. 2008 Aug 22;13(8):1817-21. [Content Brief]
[3]. Thomas P. Jerussi, et al. Methods of making and using N-desmethylzopiclone. US 6339086 B1.
[4]. Tornio A, et al. The CYP2C8 inhibitor gemfibrozil does not increase the plasma concentrations of zopiclone. Eur J Clin Pharmacol. 2006 Aug;62(8):645-51. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
N-Desmethyl zopiclone-d8 Related Classifications
HY-U00199S Related Classifications
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