Norzopiclone
Based on 1 Customer Validation
Norzopiclone is the inactive metabolite of Zopiclone. Norzopiclone has some anxiolytic properties.
For research use only. We do not sell to patients.
- Purity : 99.74%
- CAS No.: 59878-63-6
- Formula: C16H15ClN6O3
- Molecular Weight:374.78
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
The main urine metabolites of racemic zopiclone are the less active eszopiclone-N-oxide (RP 29753) and the inactive Norzopiclone (N-desmethyleszopiclone, RP 32273)[1]. Zopiclone has two major metabolites, N-oxideZopiclone and Norzopiclone (N-desmethyl-Zopiclone). N-oxideZopiclone has a hypnotic activity lower than the parent Zopiclone, whereas Norzopiclone (N-desmethyl-Zopiclone) lacks hypnotic effect, but has some anxiolytic properties[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 59878-63-6
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Appearance Solid
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Molecular Weight 374.78
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Formula C16H15ClN6O3
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Color White to off-white
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SMILES
O=C(N1CCNCC1)OC2N(C3=NC=C(Cl)C=C3)C(C4=NC=CN=C42)=O
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Synonyms
N-Desmethyl zopiclone; RP 32273
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (133.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Sha Y, et al. Synthesis of RP 48497, an impurity of eszopiclone. Molecules. 2008 Aug 22;13(8):1817-21. [Content Brief]
[2]. Thomas P. Jerussi, et al. Methods of making and using N-desmethylzopiclone. US 6339086 B1.
[3]. Tornio A, et al. The CYP2C8 inhibitor gemfibrozil does not increase the plasma concentrations of zopiclone. Eur J Clin Pharmacol. 2006 Aug;62(8):645-51. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6682 mL | 13.3412 mL | 26.6823 mL | 66.7058 mL |
| 5 mM | 0.5336 mL | 2.6682 mL | 5.3365 mL | 13.3412 mL | |
| 10 mM | 0.2668 mL | 1.3341 mL | 2.6682 mL | 6.6706 mL | |
| 15 mM | 0.1779 mL | 0.8894 mL | 1.7788 mL | 4.4471 mL | |
| 20 mM | 0.1334 mL | 0.6671 mL | 1.3341 mL | 3.3353 mL | |
| 25 mM | 0.1067 mL | 0.5336 mL | 1.0673 mL | 2.6682 mL | |
| 30 mM | 0.0889 mL | 0.4447 mL | 0.8894 mL | 2.2235 mL | |
| 40 mM | 0.0667 mL | 0.3335 mL | 0.6671 mL | 1.6676 mL | |
| 50 mM | 0.0534 mL | 0.2668 mL | 0.5336 mL | 1.3341 mL | |
| 60 mM | 0.0445 mL | 0.2224 mL | 0.4447 mL | 1.1118 mL | |
| 80 mM | 0.0334 mL | 0.1668 mL | 0.3335 mL | 0.8338 mL | |
| 100 mM | 0.0267 mL | 0.1334 mL | 0.2668 mL | 0.6671 mL |
Norzopiclone Related Classifications
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