(S)-Norzopiclone
(S)-Norzopiclone ((S)-N-Desmethyl zopiclone; SEP-174559) is a metabolite of Zopiclone with anxiolytic and anticonvulsant effects. (S)-Norzopiclone has benzodiazepine-like actions at γ2-bearing subtypes of the GABAA receptor and inhibits nACh and NMDA receptors.
For research use only. We do not sell to patients.
- CAS No.: 151776-26-0
- Formula: C16H15ClN6O3
- Molecular Weight:374.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All iGluR Isoforms
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Biological Activity
Micromolar concentrations of (S)-Norzopiclone (SEP-174559) potentiates GABAA receptor currents evoked by subsaturating concentrations of GABA[1].
(S)-Norzopiclone9 is not selective between alpha1-, alpha2-, or alpha3-bearing GABAA receptors. Within the nicotinic receptor superfamily, (S)-Norzopiclone does not affect serotonin type-3 receptor function but is found to inhibit nACh receptors[1].
In the glutamate receptor superfamily, (S)-Norzopiclone inhibits N-methyl-D-aspartate (NMDA) receptor currents but does not affect non-NMDA receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 151776-26-0
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Molecular Weight 374.78
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Formula C16H15ClN6O3
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SMILES
O=C(O[C@@H]1N(C(C2=NC=CN=C21)=O)C3=NC=C(C=C3)Cl)N4CCNCC4
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Synonyms
(S)-N-Desmethyl zopiclone; SEP-174559
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)