SN-38 glucuronide-d3
SN-38 glucuronide-d3 is deuterium labeled SN-38 glucuronide. SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer.
For research use only. We do not sell to patients.
- Formula: C28H25D3N2O11
- Molecular Weight:571.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 121080-63-5
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Molecular Weight 571.55
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Formula C28H25D3N2O11
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SMILES
O=C1C2=C(C=C3C4=NC5=CC=C(C=C5C(CC([2H])([2H])[2H])=C4CN31)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(O)=O)O)O)O)[C@@](CC)(C(OC2)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : 100 mg/mL (174.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Methanol : 6.25 mg/mL (10.94 mM; ultrasonic and warming and heat to 60°C)
H2O : 2.5 mg/mL (4.37 mM; ultrasonic and warming and heat to 60°C)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Atasilp C, et al. Determination of irinotecan, SN-38 and SN-38 glucuronide using HPLC/MS/MS: Application in a clinical pharmacokinetic and personalized medicine in colorectal cancer patients. J Clin Lab Anal. 2018 Jan;32(1):e22217. [Content Brief]
[3]. Pellock SJ, et al. Three structurally and functionally distinct β-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018;293(48):18559-18573. [Content Brief]
[4]. Wallace BD, et al. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science. 2010 Nov 5;330(6005):831-5. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / Methanol / DMSO | 1 mM | 1.7496 mL | 8.7481 mL | 17.4963 mL | 43.7407 mL |
| Methanol / DMSO | 5 mM | 0.3499 mL | 1.7496 mL | 3.4993 mL | 8.7481 mL |
| 10 mM | 0.1750 mL | 0.8748 mL | 1.7496 mL | 4.3741 mL | |
| DMSO | 15 mM | 0.1166 mL | 0.5832 mL | 1.1664 mL | 2.9160 mL |
| 20 mM | 0.0875 mL | 0.4374 mL | 0.8748 mL | 2.1870 mL | |
| 25 mM | 0.0700 mL | 0.3499 mL | 0.6999 mL | 1.7496 mL | |
| 30 mM | 0.0583 mL | 0.2916 mL | 0.5832 mL | 1.4580 mL | |
| 40 mM | 0.0437 mL | 0.2187 mL | 0.4374 mL | 1.0935 mL | |
| 50 mM | 0.0350 mL | 0.1750 mL | 0.3499 mL | 0.8748 mL | |
| 60 mM | 0.0292 mL | 0.1458 mL | 0.2916 mL | 0.7290 mL | |
| 80 mM | 0.0219 mL | 0.1094 mL | 0.2187 mL | 0.5468 mL | |
| 100 mM | 0.0175 mL | 0.0875 mL | 0.1750 mL | 0.4374 mL |
SN-38 glucuronide-d3 Related Classifications
HY-W653919 Related Classifications
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