2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. FPL 66564

FPL 66564 is a short-acting angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 5.7 nM against rabbit ACE. FPL 66564 inhibits ACE activity at the functional level and is hydrolyzed in human blood into inactive hydrophilic metabolites. FPL 66564 modulates angiotensin I-induced pressor responses in anesthetized rats, and its effects rapidly return to baseline after cessation of intravenous infusion. FPL 66564 can be used for research on cardiovascular regulation related to critical illness.

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FPL 66564

FPL 66564 Chemical Structure

CAS No. : 140369-78-4

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FPL 66564 Related Antibodies

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Description

FPL 66564 is a short-acting angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 5.7 nM against rabbit ACE. FPL 66564 inhibits ACE activity at the functional level and is hydrolyzed in human blood into inactive hydrophilic metabolites. FPL 66564 modulates angiotensin I-induced pressor responses in anesthetized rats, and its effects rapidly return to baseline after cessation of intravenous infusion. FPL 66564 can be used for research on cardiovascular regulation related to critical illness[1][2].

IC50 & Target[1]

ACE

5.7 nM (IC50)

In Vitro

FPL 66564 is degraded in human blood with a half-life of 14 minutes to form inactive, small hydrophilic products[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FPL 66564 Related Antibodies
In Vivo

FPL 66564 (100-1000 nmoL/kg/min; i.v.; continuous infusion) rapidly achieves sustained, dose-dependent inhibition of angiotensin I pressor responses in urethane-anesthetized rats, with effects that rapidly dissipate after infusion cessation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat (anesthetized with urethane)[2]
Dosage: 100 nmol/kg/min; 300 nmol/kg/min; 1000 nmol/kg/min
Administration: i.v.; continuous infusion
Result: Achieved rapid equilibrium of pressor response inhibition, followed by a sustained plateau.
Maintained ~90-95% inhibition of pressor response during infusion at 1000 nmol/kg/min dose.
Maintained ~75-80% inhibition during infusion at 300 nmol/kg/min dose.
Maintained ~60-65% inhibition during infusion at 100 nmol/kg/min dose.
Rapidly dissipated inhibitory effect on cessation of infusion, with all groups returning to near-baseline levels of inhibition (≤25%) by 60 minutes post-infusion.
Molecular Weight

238.32

Formula

C8H14O4S2
CAS No.
SMILES

SC[C@@H](C)C(O[C@H](C(O)=O)CSC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FPL 66564 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FPL 66564140369-78-4FPL66564FPL-66564Angiotensin-converting Enzyme (ACE)angiotensin IAngiotensin Converting Enzymehuman bloodrabbit ACEurethane-anesthetized ratsrabbit lung ACEcardiovascular regulationanesthetized ratsACEInhibitorinhibitorinhibit

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