140369-78-4
Chemical Structure
FPL 66564
- CAS No.: 140369-78-4
- Formula:C8H14O4S2
- Molecular Weight:238.32
InChIKey: LFBBWVTUUAFKIO-RITPCOANSA-N
SMILES: SC[C@@H](C)C(O[C@H](C(O)=O)CSC)=O
Biological Activity: FPL 66564 is a short-acting angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 5.7 nM against rabbit ACE. FPL 66564 inhibits ACE activity at the functional level and is hydrolyzed in human blood into inactive hydrophilic metabolites. FPL 66564 modulates angiotensin I-induced pressor responses in anesthetized rats, and its effects rapidly return to baseline after cessation of intravenous infusion. FPL 66564 can be used for research on cardiovascular regulation related to critical illness[1][2].
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FPL 66564 | FPL 66564 is a short-acting angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 5.7 nM against rabbit ACE. FPL 66564 inhibits ACE activity at the functional level and is hydrolyzed in human blood into inactive hydrophilic metabolites. FPL 66564 modulates angiotensin I-induced pressor responses in anesthetized rats, and its effects rapidly return to baseline after cessation of intravenous infusion. FPL 66564 can be used for research on cardiovascular regulation related to critical illness. | |||||||||||||||||||||
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- [1]. Bodor N, et al. Soft drug design: general principles and recent applications. Med Res Rev. 2000;20(1):58-101. [Content Brief]
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[2]. Baxter AJ, et al. (R)-2-(3-mercapto-2 (S)-methyl-1-oxopropoxy)-3-(methylthio) propanoic acid (FPL 66564), the first ultra-short-acting angiotensin converting enzyme inhibitor. Journal of medicinal chemistry. 1992 Oct;35(20):3718-20.
Keywords
