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inotropic agent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (2) Bacterial (1) Calcium Channel (3) COX (1) Drug Derivative (3) Fungal (1) Isotope-Labeled Compounds (3) mAChR (1) Myosin (5) Na+/K+ ATPase (1) Phosphodiesterase (PDE) (15) Potassium Channel (8) Reference Standards (4) Sodium Channel (7)
By Research Areas:	Cancer (2) Cardiovascular Disease (35) Infection (2) Inflammation/Immunology (2) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-109128

Danicamtiv 1 Publications Verification MYK-491	Myosin	Cancer
Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency .

HY-B1294

Amrinone Inamrinone	Phosphodiesterase (PDE)	Cardiovascular Disease
Amrinone (Inamrinone) is a positive inotropic-vasodilator agent. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent .

HY-12533

Disopyramide 2 Publications Verification Dicorantil; SC-7031	Sodium Channel Potassium Channel	Cardiovascular Disease
Disopyramide (Dicorantil) is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide inhibits HERG encoded potassium channels. Disopyramide also exhibits complex protein binding, and has a potent negative inotropic action .

HY-12533A

Disopyramide phosphate 2 Publications Verification Dicorantil phosphate; SC-7031 phosphate	Potassium Channel Sodium Channel	Cardiovascular Disease
Disopyramide phosphate is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide phosphate blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide phosphate inhibits HERG encoded potassium channels. Disopyramide phosphate also exhibits complex protein binding, and has a potent negative inotropic action .

HY-B1639

Enoximone	Phosphodiesterase (PDE)	Cardiovascular Disease Inflammation/Immunology
Enoximone is an inotropic vasodilating agent and a selective and orally active phosphodiesterase III (PDE3) inhibitor with an IC₅₀ of 5.9 μM. Enoximone induces vasodilatation and increases intracellular levels of cAMP by inhibiting cGMP-inhibited PDE. Enoximone also exhibits PDE4 inhibitory effect with an IC₅₀ of 21.1 μM for myocardial PDE4A. Enoximone has the potential for congestive heart failure research and has bronchodilatory, antiasthma and anti-inflammatory effects .

HY-19666

DPI 201-106 1 Publications Verification SDZ 201106	Sodium Channel	Cardiovascular Disease
DPI 201-106 (SDZ 201106) is a cardiotonic agent with a synergistic sarcolemmal and intracellular mechanism of action. DPI 201-106 shows cardioselective modulation of voltage-gated sodium channels (VGSCs) resulting in a positive inotropic effect .

HY-N1433

Phytolaccagenin	Fungal mAChR Adrenergic Receptor Calcium Channel	Cardiovascular Disease Infection Inflammation/Immunology
Phytolaccagenin is a triterpenoid saponin aglycone, Antifungal agent, vasodilator, antihypertensive agent, and anti-inflammatory agent. Phytolaccagenin activates vascular and cardiac Muscarinic receptors, blocks cardiac β-adrenergic receptors, and inhibits voltage-dependent calcium channels in blood vessels. Phytolaccagenin inhibits the growth of Candida albicans and Cryptococcus neoformans. Phytolaccagenin induces vasodilation, produces negative inotropic and negative chronotropic effects, reduces mean arterial pressure, and inhibits LPS-induced inflammation. Phytolaccagenin exhibits enhanced antihypertensive effects in high salt-induced hypertensive rats. Phytolaccagenin can be used in the research of candidiasis, cryptococcosis, hypertension, and inflammation-related diseases .

HY-14252A

Milrinone lactate Maximum Cited Publications 33 Publications Verification Win 47203 lactate	Phosphodiesterase (PDE)	Cardiovascular Disease
Milrinone lactate is a potent inotropic dilating agent. Milrinone lactate shows simultaneous positive inotropic and vasodilating activities. Milrinone lactate promotes reduction of SVR and PVR in patients with DCM and NYHA class III and IV of heart failure. Milrinone lactate has the potential for the research of cardiovascular function after cardiac surgery and in septic shock .

HY-165439

Indolidan LY195115	Phosphodiesterase (PDE)	Cardiovascular Disease
Indolidan (LY195115) is an orally active cardiotonic agent and a selective cyclic nucleotide phosphodiesterase inhibitor. Indolidan has a K_i of 80 nM for sarcoplasmic reticulum phosphodiesterase (SR-PDE). Indolidan exhibits positive inotropic and vasodilator effects. Indolidan can be used in the research of diseases such as congestive heart failure .

HY-W017764

7,8-Dihydro-2,5(1H,6H)-quinolinedione	Drug Derivative	Cardiovascular Disease
7,8-Dihydro-2,5(1H,6H)-quinolinedione (compound SF32) is a positive inotropic agent .

HY-153168

Bemoradan	Phosphodiesterase (PDE)	Cardiovascular Disease
Bemoradan (compound 10a) is an orally active and selective canine Phosphodiesterase (PDE) fraction III inhibitor. Bemoradan is a long-acting, potent, inotropic vasodilator and a novel cardiotonic agent, and can be used in congestive heart failure research .

HY-106844

EMD 53998	Phosphodiesterase (PDE)	Cardiovascular Disease
EMD 53998 is a cardiotonic agent that increases myocardial contractility as an inhibitor for phosphodiesterase III (PDE III) and a calcium sensitizer. EMD 53998 increases myocardial contractility, reduces energy consumption and the risk of inducing arrhythmias .

HY-120577

BA 41899	Others	Cardiovascular Disease
BA 41899 is a purely calcium-sensitizing agent. BA 41899 is completely devoid of phosphodiesterase (PDE) III inhibitory activity or any other known inotropic mechanism. BA 41899 can be used for the research of cardiovascular diseases, such as congestive heart failure (CHF) .

HY-163120

Myosin-IN-1	Myosin	Cardiovascular Disease
Myosin-IN-1 (compound F10) is a Myosin inhibitor that specifically targets cardiac myosin. Myosin-IN-1 stabilizes the biochemical and structural closed state of the cardiac myosin motor domain and reduces myocardial force production and calcium sensitivity in vitro. Myosin-IN-1 acts as a negative inotropic agent in isolated Langendroff-perfused rat hearts, reducing stress in isolated myofilaments and left ventricular pressure development. Myosin-IN-1 can be used in heart failure research .

HY-105057

MDL 19205	Phosphodiesterase (PDE)	Cardiovascular Disease
MDL 19205 is a cardiotonic agent with inotropic effect. MDL 19205 can be used for the research of cardiovascular disease, such as heart failure .

HY-165436

Toborinone	Phosphodiesterase (PDE)	Cardiovascular Disease
Toborinone is an inotropic agent. Toborinone increases cAMP and intracellular calcium levels through inhibiting PDE. Toborinone inhibits thrombin-induced platelet aggregation with an IC₅₀ of 9.7 μM .

HY-109128S

Danicamtiv-d6 MYK-491-d₆	Isotope-Labeled Compounds Myosin	Cardiovascular Disease
Danicamtiv-d₆ (MYK-491-d₆) is a deuterated labeled Danicamtiv (HY-109128). Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency .

HY-167079

OPC-18750	Drug Derivative	Cardiovascular Disease
OPC-18750 is a novel positive inotropic agent and 2(lH)-quinolinone derivative. OPC-18750 displays positive inotropic and coronary vasodilating effects .

HY-113547

Nanterinone UK 61260	Phosphodiesterase (PDE)	Cardiovascular Disease
Nanterinone (UK 61260) is a positive inotropic and arterial vasodilating agent. Nanterinone is a phosphodiesterase inhibitor .

HY-16256

Amrinone lactate	Phosphodiesterase (PDE)	Cardiovascular Disease
Amrinone lactate is a positive inotropic-vasodilator agent. Amrinone lactate is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone lactate is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent .

HY-113847

Nanterinone mesylate UK-61260-27	Phosphodiesterase (PDE)	Cardiovascular Disease
Nanterinone mesylate (UK-61260-27) is an orally active and positive inotropic and balanced-type vasodilating agent, partially based on phosphodiesterase III inhibition with venodilating properties. Nanterinone mesylate is promising for research of cardiovascular diseases .

HY-B1294R

Amrinone (Standard) Inamrinone (Standard)	Reference Standards Phosphodiesterase (PDE)	Cardiovascular Disease
Amrinone (Standard) is the analytical standard of Amrinone. This product is intended for research and analytical applications. Amrinone (Inamrinone) is a positive inotropic-vasodilator agent. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent .

HY-109128S1

Danicamtiv-d3 MYK-491-d₃	Isotope-Labeled Compounds Myosin	Cardiovascular Disease
Danicamtiv-d₃ (MYK-491-d₃) is a deuterated labeled Danicamtiv (HY-109128). Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency .

HY-109128S2

Danicamtiv-d3-1 MYK-491-d₃-1	Isotope-Labeled Compounds Myosin	Cardiovascular Disease
Danicamtiv-d₃-1 (MYK-491-d₃-1) is a deuterated labeled Danicamtiv (HY-109128). Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency .

HY-117715

CK-3197	Phosphodiesterase (PDE)	Cardiovascular Disease
CK-3197 is a weak inhibitor of Peak lll cyclic 3'5'-adenosine monophosphate phosphodiesterase (CAMP PDEl). CK-3197 has hemodynamic and myocardial energetic effects in vivo. CK-3197 is an imidazolone derivative used as a selective positive inotropic agent for congestive heart failure .

HY-12533B

Disopyramide hydrochloride Dicorantil hydrochloride; SC-7031 hydrochloride	Sodium Channel Potassium Channel	Cardiovascular Disease
Disopyramide hydrochloride is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide hydrochloride blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide hydrochloride inhibits HERG encoded potassium channels. Disopyramide hydrochloride also exhibits complex protein binding, and has a potent negative inotropic action .

HY-15718B

Istaroxime oxalate PST2744 oxalate	Na+/K+ ATPase	Cardiovascular Disease
Istaroxime oxalate (PST2744 oxalate) is the oxalate form of Istaroxime (HY-15718). Istaroxime oxalate is is an inotropic agent, that inhibits Na ⁺/K ⁺-ATPase with an IC₅₀ of 0.11 μM. Istaroxime oxalate increases force of contraction in guinea pig atria and twitch amplitude in isolated guinea pig myocytes without causing lethal arrhythmias .

HY-19666R

DPI 201-106 (Standard) SDZ 201106 (Standard)	Sodium Channel Reference Standards	Cardiovascular Disease
DPI 201-106 (Standard) is the analytical standard of DPI 201-106. This product is intended for research and analytical applications. DPI 201-106 (SDZ 201106) is a cardiotonic agent with a synergistic sarcolemmal and intracellular mechanism of action. DPI 201-106 shows cardioselective modulation of voltage-gated sodium channels (VGSCs) resulting in a positive inotropic effect .

HY-12533R

Disopyramide (Standard) Dicorantil (Standard); SC-7031 (Standard)	Reference Standards Sodium Channel Potassium Channel	Cardiovascular Disease
Disopyramide (Standard) is the analytical standard of Disopyramide. This product is intended for research and analytical applications. Disopyramide (Dicorantil) is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide inhibits HERG encoded potassium channels. Disopyramide also exhibits complex protein binding, and has a potent negative inotropic action .

HY-12533AR

Disopyramide phosphate (Standard) Dicorantil phosphate (Standard); SC-7031 phosphate (Standard)	Potassium Channel Sodium Channel Reference Standards	Cardiovascular Disease
Disopyramide (phosphate) (Standard) is the analytical standard of Disopyramide (phosphate). This product is intended for research and analytical applications. Disopyramide phosphate is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide phosphate blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide phosphate inhibits HERG encoded potassium channels. Disopyramide phosphate also exhibits complex protein binding, and has a potent negative inotropic action .

HY-W748419

Acetylstrophanthidin	Others	Cardiovascular Disease
Acetylstrophanthidin is a cardiac glycoside compound and a positive inotropic agent. Acetylstrophanthidin increases myocardial oxygen consumption in cat papillary muscles under constant load or tension, as well as under afterload (isotonic) and isometric contraction conditions .

HY-N19224

Pulvinic acid dilactone	Drug Derivative Bacterial	Infection Neurological Disease Cancer
Pulvinic acid dilactone is a Pulvinic acid derivative and Antibacterial agent. Pulvinic acid dilactone can be isolated from the lichen Candelaria concolor. Pulvinic acid dilactone moderately inhibits the growth of Bacillus subtilis. Pulvinic acid dilactone exerts positive inotropic effects. Pulvinic acid dilactone can be used in studies related to Bacillus subtilis infections and leukemia .

HY-106830

Pelrinone	Phosphodiesterase (PDE)	Cardiovascular Disease
Pelrinone is an orally active cardiotonic agent and PDE III inhibitor with an IC₅₀ of 36 μM. Pelrinone elevates intracellular cAMP levels. The action of Pelrinone is independent of β-adrenergic receptors, and it does not inhibit Na ⁺/K ⁺-ATPase. Pelrinone exerts positive inotropic and vasodilatory effects. Pelrinone inhibits platelet aggregation, reduces thrombus formation, and exerts weak anticoagulant activity without altering hematocrit or circulating platelet counts. Pelrinone can be used in research related to congestive heart failure and coronary thrombosis .

HY-N8421

Tabernanthine	Potassium Channel	Cardiovascular Disease
Tabernanthine is a negative chronotropic and negative inotropic agent that selectively acts on sinoatrial node receptors, regulating heart rhythm and myocardial contractility. Tabernanthine exhibits atropine resistance and direct non-cholinergic binding properties, acting directly on the sinoatrial node rather than relying on vagal nerve or cholinergic pathways to exert its key activity of slowing heart rate and weakening myocardial contractility. Tabernanthine is useful in cardiovascular pharmacology research, particularly in the areas of sinoatrial node function regulation, mechanisms related to bradycardia, and studies of cardiac receptor subtype differences .

HY-124940

CPU-228	Calcium Channel Potassium Channel	Cardiovascular Disease
CPU-228 is a complex class III antiarrhythmic agent. CPU-228 concentration-dependently blocks the activities of the rapid component 50 of the delayed rectifier potassium channel (I_Kr) and the L-type calcium channel (I_Ca,L), with an IC₅₀ value of 0.909 μM for I_Ca,L current. CPU-228 produces negative inotropic effects and induces mild, non-frequency-dependent prolongation of the effective refractory period (ERP) in isolated left atria. CPU-228 reduces the incidence of torsades de pointes (TDP) in anesthetized rabbits and inhibits ischemia/reperfusion-induced arrhythmias in rats. CPU-228 can be used in studies related to torsades de pointes .

HY-165486

AWD 122-60	Potassium Channel Calcium Channel	Cardiovascular Disease
AWD 122-60 is a potassium channel blocker and calcium sensitizer, with IC₅₀ values of 11 μM and 29 μM, respectively, against mouse skeletal muscle ATP-sensitive potassium (K_ATP) channels. AWD 122-60 exerts potent positive inotropic activity. AWD 122-60 exhibits antiarrhythmic activity in vivo and prolongs myocardial refractory period in vitro. AWD 122-60 can be used for research related to arrhythmias .

HY-19091

ICI-170777	Phosphodiesterase (PDE) Adrenergic Receptor COX	Cardiovascular Disease
ICI-170777 is an orally active cardiotonic agent and type III Phosphodiesterase inhibitor, with an IC₅₀ of 2.5 μM against cyclic AMP phosphodiesterase type III from canine cardiac fractions. ICI-170777 inhibits Aldrin epoxidase and pentobarbital metabolism. It enhances β-adrenergic receptor-mediated positive inotropic effects without causing chronotropic effects, while also exerting balanced arteriolar/venular vasodilator, platelet aggregation inhibitor and smooth muscle relaxant activities. ICI-170777 restores cardiac function in an acute canine heart failure model, exhibits additive effects when combined with Ouabain (HY-B1457), and shows no significant activity against multiple receptor classes or non-cardiac systems. ICI-170777 can be used in research related to congestive heart failure .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1433

Phytolaccagenin	Triterpenes Structural Classification Classification of Application Fields Terpenoids Phytolacca acinosa Roxb. Plants Inflammation/Immunology Disease Research Fields Phytolaccaceae Source Classification	Fungal mAChR Adrenergic Receptor Calcium Channel
Phytolaccagenin is a triterpenoid saponin aglycone, Antifungal agent, vasodilator, antihypertensive agent, and anti-inflammatory agent. Phytolaccagenin activates vascular and cardiac Muscarinic receptors, blocks cardiac β-adrenergic receptors, and inhibits voltage-dependent calcium channels in blood vessels. Phytolaccagenin inhibits the growth of Candida albicans and Cryptococcus neoformans. Phytolaccagenin induces vasodilation, produces negative inotropic and negative chronotropic effects, reduces mean arterial pressure, and inhibits LPS-induced inflammation. Phytolaccagenin exhibits enhanced antihypertensive effects in high salt-induced hypertensive rats. Phytolaccagenin can be used in the research of candidiasis, cryptococcosis, hypertension, and inflammation-related diseases .

HY-W748419

Acetylstrophanthidin	Structural Classification Endogenous metabolite Steroids Source Classification	Others
Acetylstrophanthidin is a cardiac glycoside compound and a positive inotropic agent. Acetylstrophanthidin increases myocardial oxygen consumption in cat papillary muscles under constant load or tension, as well as under afterload (isotonic) and isometric contraction conditions .

HY-N19224

Pulvinic acid dilactone	Structural Classification Natural Products Microorganisms Source Classification	Drug Derivative Bacterial
Pulvinic acid dilactone is a Pulvinic acid derivative and Antibacterial agent. Pulvinic acid dilactone can be isolated from the lichen Candelaria concolor. Pulvinic acid dilactone moderately inhibits the growth of Bacillus subtilis. Pulvinic acid dilactone exerts positive inotropic effects. Pulvinic acid dilactone can be used in studies related to Bacillus subtilis infections and leukemia .

HY-N8421

Tabernanthine	Apocynaceae Structural Classification Alkaloids Plants Indole Alkaloids Tabernanthe iboga Baill. Source Classification	Potassium Channel
Tabernanthine is a negative chronotropic and negative inotropic agent that selectively acts on sinoatrial node receptors, regulating heart rhythm and myocardial contractility. Tabernanthine exhibits atropine resistance and direct non-cholinergic binding properties, acting directly on the sinoatrial node rather than relying on vagal nerve or cholinergic pathways to exert its key activity of slowing heart rate and weakening myocardial contractility. Tabernanthine is useful in cardiovascular pharmacology research, particularly in the areas of sinoatrial node function regulation, mechanisms related to bradycardia, and studies of cardiac receptor subtype differences .

Cat. No.	Product Name	Chemical Structure

HY-109128S

Danicamtiv-d6
Danicamtiv-d₆ (MYK-491-d₆) is a deuterated labeled Danicamtiv (HY-109128). Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency .

HY-109128S1

Danicamtiv-d3
Danicamtiv-d₃ (MYK-491-d₃) is a deuterated labeled Danicamtiv (HY-109128). Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency .

HY-109128S2

Danicamtiv-d3-1
Danicamtiv-d₃-1 (MYK-491-d₃-1) is a deuterated labeled Danicamtiv (HY-109128). Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency .

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inotropic agent

Inhibitors & Agonists

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Isotope-Labeled Compounds

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