2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Potassium Channel Calcium Channel
  4. AWD 122-60

AWD 122-60 is a potassium channel blocker and calcium sensitizer, with IC50 values of 11 μM and 29 μM, respectively, against mouse skeletal muscle ATP-sensitive potassium (KATP) channels. AWD 122-60 exerts potent positive inotropic activity. AWD 122-60 exhibits antiarrhythmic activity in vivo and prolongs myocardial refractory period in vitro. AWD 122-60 can be used for research related to arrhythmias.

For research use only. We do not sell to patients.

AWD 122-60

AWD 122-60 Chemical Structure

CAS No. : 108610-89-5

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AWD 122-60 Related Antibodies

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Description

AWD 122-60 is a potassium channel blocker and calcium sensitizer, with IC50 values of 11 μM and 29 μM, respectively, against mouse skeletal muscle ATP-sensitive potassium (KATP) channels. AWD 122-60 exerts potent positive inotropic activity. AWD 122-60 exhibits antiarrhythmic activity in vivo and prolongs myocardial refractory period in vitro. AWD 122-60 can be used for research related to arrhythmias[1][2].

IC50 & Target[1]

KATP

11 or 29 μM (IC50)

In Vitro

AWD 122-60 exerts potent positive inotropic activity and negative chronotropic effects[1].
AWD 122-60 (1-1000 μM) reversibly inhibits KATP channels in inside-out patch-clamp preparations isolated from skeletal muscle fibers of the flexor digitorum brevis of adult mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AWD 122-60 Related Antibodies
In Vivo

AWD 122-60 exhibits antiarrhythmic activity in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

309.42

Formula

C18H23N5
CAS No.
SMILES

N#CC=1C=C(C=NC1NCCCN(CC)CC)C=2C=CN=CC2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AWD 122-60 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AWD 122-60108610-89-5Potassium ChannelCalcium ChannelKcsACa2+ channelsCa channelspotassium channel blockerantiarrhythmic agentacute myocardial ischemianegative chronotropic agentpositive inotropic agentcalcium sensitizermouse skeletal muscle ATP-sensitive potassium (K(ATP)) channelmouse flexor digitorum brevis skeletal muscle fibresmyocardial refractory period prolongerarrhythmiaInhibitorinhibitorinhibit

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