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Cat. No.: HY-165486

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AWD 122-60

AWD 122-60 is a potassium channel blocker and calcium sensitizer, with IC₅₀ values of 11 μM and 29 μM, respectively, against mouse skeletal muscle ATP-sensitive potassium (K_ATP) channels. AWD 122-60 exerts potent positive inotropic activity. AWD 122-60 exhibits antiarrhythmic activity in vivo and prolongs myocardial refractory period in vitro. AWD 122-60 can be used for research related to arrhythmias.

For research use only. We do not sell to patients.

CAS No.: 108610-89-5
Formula: C₁₈H₂₃N₅
Molecular Weight:309.42

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Please store the product under the recommended conditions in the Certificate of Analysis.

AWD 122-60 Chemical Structure

CAS No.: 108610-89-5

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

IC₅₀ & Target^[1]

K_ATP

11 or 29 μM (IC₅₀)

All Calcium Channel Isoforms :

In Vitro

AWD 122-60 exerts potent positive inotropic activity and negative chronotropic effects^[1].
AWD 122-60 (1-1000 μM) reversibly inhibits K_ATP channels in inside-out patch-clamp preparations isolated from skeletal muscle fibers of the flexor digitorum brevis of adult mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AWD 122-60 exhibits antiarrhythmic activity in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 108610-89-5
Molecular Weight 309.42
Formula C₁₈H₂₃N₅
SMILES

N#CC=1C=C(C=NC1NCCCN(CC)CC)C=2C=CN=CC2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Abignente E, Arena F, Luraschi E, et al. P95 heterocyclic antiinflammatory agents: Imidazo [1, 2-1] pyramidines[J]. European Journal of Pharmaceutical Sciences, 1994, 2(1-2): 142.

[2]. Bodewei R, et al. The cardiotonic bipyridine AWD 122-60 inhibits adenosine triphosphate-sensitive potassium channels of mouse skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol. 1992;345(5):570-577. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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AWD 122-60

All Calcium Channel Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

AWD 122-60 Related Classifications

HY-165486 Related Classifications