108610-89-5
Chemical Structure
AWD 122-60
- CAS No.: 108610-89-5
- Formula:C18H23N5
- Molecular Weight:309.42
IUPAC Name: 6-((3-(diethylamino)propyl)amino)-[3,4'-bipyridine]-5-carbonitrile
InChIKey: PGTGATAQGNXSIO-UHFFFAOYSA-N
SMILES: N#CC=1C=C(C=NC1NCCCN(CC)CC)C=2C=CN=CC2
Biological Activity: AWD 122-60 is a potassium channel blocker and calcium sensitizer, with IC50 values of 11 μM and 29 μM, respectively, against mouse skeletal muscle ATP-sensitive potassium (KATP) channels. AWD 122-60 exerts potent positive inotropic activity. AWD 122-60 exhibits antiarrhythmic activity in vivo and prolongs myocardial refractory period in vitro. AWD 122-60 can be used for research related to arrhythmias[1][2].
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AWD 122-60 | AWD 122-60 is a potassium channel blocker and calcium sensitizer, with IC50 values of 11 μM and 29 μM, respectively, against mouse skeletal muscle ATP-sensitive potassium (KATP) channels. AWD 122-60 exerts potent positive inotropic activity. AWD 122-60 exhibits antiarrhythmic activity in vivo and prolongs myocardial refractory period in vitro. AWD 122-60 can be used for research related to arrhythmias. | |||||||||||||||||||||
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- [1]. Abignente E, Arena F, Luraschi E, et al. P95 heterocyclic antiinflammatory agents: Imidazo [1, 2-1] pyramidines[J]. European Journal of Pharmaceutical Sciences, 1994, 2(1-2): 142.
- [2]. Bodewei R, et al. The cardiotonic bipyridine AWD 122-60 inhibits adenosine triphosphate-sensitive potassium channels of mouse skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol. 1992;345(5):570-577. [Content Brief]
Keywords
