CPU-228

CPU-228 (0.01-1 μM) concentration-dependently blocks I_Kr in isolated guinea pig ventricular myocytes without altering the activities of I_Ks or I_K1^[1].
CPU-228 (0.33-10 μM) concentration-dependently blocks I_Ca,L in isolated guinea pig ventricular myocytes, with an IC₅₀ of 0.909 μM. It also alters the kinetic properties of I_Ca,L by shifting the steady-state inactivation curve to more negative potentials, without affecting its activation characteristics^[1].
CPU-228 (3.3 μM; 5 min) significantly inhibits systolic cytoplasmic calcium transients in isolated rat ventricular myocytes without altering diastolic calcium levels or the decay kinetics of calcium transients^[1].
CPU-228 (10 nM-100 μM; 15 min) concentration-dependently prolongs the ERP of isolated left atria in guinea pigs without reverse frequency dependence; within the pacing frequency range of 0.5-2.0 Hz, it induces a 23%-24% prolongation at the concentration of 100 μM^[1].
CPU-228 (10 nM-100 μM) exerts a concentration-dependent negative inotropic effect on isolated left atria of guinea pigs, with an IC₅₀ of 69.2 μM, and significantly reduces contractile force at 100 μM^[1].

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