446877-42-5
Chemical Structure
CPU-228
- CAS No.: 446877-42-5
- Formula:C23H26N2O4S
- Molecular Weight:426.53
IUPAC Name: N-(4-(methylsulfonamido)phenethyl)-N-(2-(naphthalen-1-yloxy)ethyl)acetamide
InChIKey: NSXHCQYUSBIMAJ-UHFFFAOYSA-N
SMILES: O=C(N(CCOC1=CC=CC=2C=CC=CC12)CCC3=CC=C(C=C3)NS(=O)(=O)C)C
Biological Activity: CPU-228 is a complex class III antiarrhythmic agent. CPU-228 concentration-dependently blocks the activities of the rapid component 50 of the delayed rectifier potassium channel (IKr) and the L-type calcium channel (ICa,L), with an IC50 value of 0.909 μM for ICa,L current. CPU-228 produces negative inotropic effects and induces mild, non-frequency-dependent prolongation of the effective refractory period (ERP) in isolated left atria. CPU-228 reduces the incidence of torsades de pointes (TDP) in anesthetized rabbits and inhibits ischemia/reperfusion-induced arrhythmias in rats. CPU-228 can be used in studies related to torsades de pointes[1].
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CPU-228 | CPU-228 is a complex class III antiarrhythmic agent. CPU-228 concentration-dependently blocks the activities of the rapid component 50 of the delayed rectifier potassium channel (IKr) and the L-type calcium channel (ICa,L), with an IC50 value of 0.909 μM for ICa,L current. CPU-228 produces negative inotropic effects and induces mild, non-frequency-dependent prolongation of the effective refractory period (ERP) in isolated left atria. CPU-228 reduces the incidence of torsades de pointes (TDP) in anesthetized rabbits and inhibits ischemia/reperfusion-induced arrhythmias in rats. CPU-228 can be used in studies related to torsades de pointes. | |||||||||||||||||||||
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Keywords
