2. Disopyramide phosphate

Disopyramide phosphate  (Synonyms: Dicorantil phosphate; SC-7031 phosphate)

Cat. No.: HY-12533A
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Disopyramide phosphate is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide phosphate blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide phosphate inhibits HERG encoded potassium channels. Disopyramide phosphate also exhibits complex protein binding, and has a potent negative inotropic action.

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Disopyramide phosphate Chemical Structure

Disopyramide phosphate Chemical Structure

CAS No. : 22059-60-5

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Disopyramide phosphate Related Antibodies

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Description

Disopyramide phosphate is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide phosphate blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide phosphate inhibits HERG encoded potassium channels. Disopyramide phosphate also exhibits complex protein binding, and has a potent negative inotropic action[1][2][3].

In Vitro

HERG tail currents recorded at -40 mV following test pulses to +30 mV were inhibited in a dose-dependent fashion by Disopyramide concentrations within the clinical range (IC50=7.23 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Disopyramide phosphate Related Antibodies
Clinical Trial
Molecular Weight

437.47

Formula

C21H32N3O5P
CAS No.
SMILES

O=P(O)(O)O.NC(C(C1=CC=CC=C1)(C2=CC=CC=N2)CCN(C(C)C)C(C)C)=O
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Keywords:

Disopyramide22059-60-5DicorantilSC-7031SC7031SC 7031Inhibitorinhibitorinhibit

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