1. Membrane Transporter/Ion Channel
  2. Sodium Channel
    Potassium Channel
  3. Disopyramide

Disopyramide (Synonyms: Dicorantil; SC-7031)

Cat. No.: HY-12533 Purity: >98.0%
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Disopyramide (Dicorantil) is a class IA antiarrhythmic drug with efficacy in ventricular and atrial arrhythmias. Disopyramide blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide inhibits HERG encoded potassium channels. Disopyramide also exhibits complex protein binding, and has a potent negative inotropic action.

For research use only. We do not sell to patients.

Disopyramide Chemical Structure

Disopyramide Chemical Structure

CAS No. : 3737-09-5

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10 mM * 1  mL in DMSO USD 44 In-stock
Estimated Time of Arrival: December 31
10 mg USD 40 In-stock
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100 mg USD 169 In-stock
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Description

Disopyramide (Dicorantil) is a class IA antiarrhythmic drug with efficacy in ventricular and atrial arrhythmias. Disopyramide blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide inhibits HERG encoded potassium channels. Disopyramide also exhibits complex protein binding, and has a potent negative inotropic action[1][2][3].

In Vitro

HERG tail currents recorded at -40 mV following test pulses to +30 mV were inhibited in a dose-dependent fashion by Disopyramide concentrations within the clinical range (IC50=7.23 μM)[1].

Molecular Weight

339.47

Formula

C₂₁H₂₉N₃O

CAS No.

3737-09-5

SMILES

NC(C(C1=CC=CC=C1)(C2=CC=CC=N2)CCN(C(C)C)C(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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Keywords:

DisopyramideDicorantilSC-7031SC7031SC 7031Sodium ChannelPotassium ChannelNa channelsNa+ channelsKcsAantiarrhythmicventricularatrialarrhythmiasactionnegativeinotropicInhibitorinhibitorinhibit

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Disopyramide
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