2. Cytoskeleton
  3. Myosin
  4. Danicamtiv

Danicamtiv  (Synonyms: MYK-491)

Cat. No.: HY-109128 Purity: 99.12%
COA Handling Instructions

Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.

For research use only. We do not sell to patients.

Danicamtiv Chemical Structure

Danicamtiv Chemical Structure

CAS No. : 1970972-74-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 385 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 385 In-stock
Solid
1 mg USD 200 In-stock
5 mg USD 350 In-stock
10 mg USD 580 In-stock
25 mg USD 1180 In-stock
50 mg USD 1700 In-stock
100 mg USD 2500 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Danicamtiv Related Antibodies

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Description

Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency[1].

In Vivo

Danicamtiv selectively enhances cardiac actomyosin activity, the molecular force‐generating unit of the sarcomere, prolonging contraction while preserving actin–myosin detachment, allowing relaxation, and without impacting Ca2+ homeostasis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

435.42

Appearance

Solid

Formula

C16H20F3N5O4S
CAS No.
SMILES

O=S([C@@](C1CCN(CC1)C(NC2=NOC=C2)=O)(C)F)(C3=CN(N=C3C(F)F)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (114.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2966 mL 11.4832 mL 22.9663 mL
5 mM 0.4593 mL 2.2966 mL 4.5933 mL
10 mM 0.2297 mL 1.1483 mL 2.2966 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Danicamtiv Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Danicamtiv1970972-74-7MYK-491MYK491MYK 491Myosininotropicallostericcardiacacto-myosinsystolicfunctionInhibitorinhibitorinhibit

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