1. Cytoskeleton
  2. Myosin
  3. Danicamtiv

Danicamtiv 

Cat. No.: HY-109128 Purity: 99.49%
Handling Instructions

Danicamtiv, an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.

For research use only. We do not sell to patients.

Danicamtiv Chemical Structure

Danicamtiv Chemical Structure

CAS No. : 1970972-74-7

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 638 In-stock
Estimated Time of Arrival: December 31
5 mg USD 580 In-stock
Estimated Time of Arrival: December 31
10 mg USD 900 In-stock
Estimated Time of Arrival: December 31
25 mg USD 2000 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

Danicamtiv, an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency[1].

Molecular Weight

435.42

Formula

C₁₆H₂₀F₃N₅O₄S

CAS No.

1970972-74-7

SMILES

O=S([[email protected]@](C1CCN(CC1)C(NC2=NOC=C2)=O)(C)F)(C3=CN(N=C3C(F)F)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (114.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2966 mL 11.4832 mL 22.9663 mL
5 mM 0.4593 mL 2.2966 mL 4.5933 mL
10 mM 0.2297 mL 1.1483 mL 2.2966 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DanicamtivMyosininotropicallostericcardiacacto-myosinsystolicfunctionInhibitorinhibitorinhibit

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Product Name:
Danicamtiv
Cat. No.:
HY-109128
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