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nucleoside derivative

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5

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0262
    Cordycepin
    10+ Cited Publications

    3'-Deoxyadenosine

    		 TNF Receptor MMP Bacterial Autophagy Antibiotic Infection Inflammation/Immunology Cancer
    Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase .
    Cordycepin
  • HY-20140
    5'-O-DMT-dT

    5'-O-(4,4'-Dimethoxytrityl)thymidine

    		 Phosphoramidites DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Others
    5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative which can be used in the preparation of oligonucleotides .
    5'-O-DMT-dT
  • HY-W019033
    8-Bromoguanosine

    		Nucleoside Antimetabolite/Analog Others
    8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function .
    8-Bromoguanosine
  • HY-W008662
    2'-Deoxy-5'-O-DMT-2'-fluorouridine
    1 Publications Verification

    		 Phosphoramidites Filovirus Infection
    2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5’-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity .
    2'-Deoxy-5'-O-DMT-2'-fluorouridine
  • HY-104014
    DMT-2'O-MOE-rG(ib) Phosphoramidite

    		Phosphoramidites DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Others
    DMT-2'O-MOE-rG(ib) Phosphoramidite belongs to cyanoethyl-protected nucleoside phosphoramidites. DMT-2'O-MOE-rG(ib) Phosphoramidite is a derivative of nucleotide and guanosine. DMT-2'O-MOE-rG(ib) Phosphoramidite can be used for the stereochemical synthesis of phosphorothioate oligonucleotides .
    DMT-2'O-MOE-rG(ib) Phosphoramidite
  • HY-W003486
    5,7-Dichloropyrazolo[1,5-a]pyrimidine

    		Phosphodiesterase (PDE) Neurological Disease Cancer
    5,7-Dichloropyrazolo[1,5-a]pyrimidine is a PDE10A inhibitor with a Ki of 24 μM. 5,7-Dichloropyrazolo[1,5-a]pyrimidine serves as a key intermediate in the synthesis of 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives (HIV-1 non-nucleoside reverse transcriptase inhibitors). 5,7-Dichloropyrazolo[1,5-a]pyrimidine can be used for the research of schizophrenia .
    5,7-Dichloropyrazolo[1,5-a]pyrimidine
  • HY-W013403
    2'-Deoxy-2'-fluorouridine

    		IFNAR Infection
    2'-Deoxy-2'-fluorouridine is a derivative of the pyrimidine nucleoside uridine. 2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. Hepatitis C polyU/UC RNA strands containing 2'-Deoxy-2'-fluorouridine, bind to RIG-I but do not activate RIG-I signaling in a reporter assay using Huh7 cells. 2'-Deoxy-2'-fluorouridine also has been used as a starting material in the synthesis of respiratory syncytial virus (RSV) polymerase inhibitors. 2'-Deoxy-2'-fluorouridine can incorporate into DNA and RNA in rat and woodchuck model upon administration. 2'-Deoxy-2'-fluorouridine can be studied in anti-viral research .
    2'-Deoxy-2'-fluorouridine
  • HY-120832
    Azt-pmap

    		HIV Infection
    Azt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. Azt-pmap shows anti-HIV activity . AZT is a nucleoside reverse transcriptase inhibitor (NRTI) for HIV infection . Azt-pmap is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azt-pmap
  • HY-111531
    DMTr-LNA-5MeU-3-CED-phosphoramidite

    		Phosphoramidites Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Others
    DMTr-LNA-5MeU-3-CED-phosphoramidite is a Phosphoramidite derivative and Nucleoside derivative .
    DMTr-LNA-5MeU-3-CED-phosphoramidite
  • HY-W010744
    DMT-dI

    5'-O-DMT-dI; 2'-Deoxy-5'-O-DMT-inosine

    		 Phosphoramidites Nucleoside Antimetabolite/Analog Cancer
    DMT-dI (5'-O-DMT-dI) is a deoxyribonucleoside containing a hypoxanthine base. DMT-dI can be used to prepare convertible nucleoside derivatives to prepare modified oligonucleotides complementary to target genes for gene editing. DMT-dI can be used to study various conditions, disorders or diseases modified by adenosine .
    DMT-dI
  • HY-W013330
    3′-Deoxyguanosine

    Guanosine, 3'-deoxy-

    		 Nucleoside Antimetabolite/Analog Drug Derivative Metabolic Disease
    3′-Deoxyguanosine (Guanosine, 3'-deoxy-) is a derivative of Guanosine (HY-N0097). 3′-Deoxyguanosine interacts with human purine nucleoside phosphorylase via hydrogen bonding with residues such as Glu201 and Asn243. 3′-Deoxyguanosine exhibits moderate displacement activity for [ 3H]-guanosine in rat meninges. 3′-Deoxyguanosine is useful for studying the mechanism of guanosine receptors and purine metabolism .
    3′-Deoxyguanosine
  • HY-N6666
    Vidarabine monohydrate
    5+ Cited Publications

    		 Nucleoside Antimetabolite/Analog DNA/RNA Synthesis HSV VZV CMV EBV Infection
    Vidarabine monohydrate is a Purine nucleoside derivative and Antiviral agent. The triphosphate derivative of Vidarabine monohydrate competitively inhibits DNA polymerase, incorporates into the terminus of elongating DNA molecules, and interferes with the early steps of viral DNA synthesis. Vidarabine monohydrate inhibits the replication of herpes simplex virus, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus and vaccinia virus, reduces viral shedding, and accelerates skin healing. Vidarabine monohydrate is metabolized to arabinosyl hypoxanthine, causes minimal impairment of corneal wound healing in rabbit models, and is associated with recurrence of herpes simplex encephalitis. Vidarabine monohydrate can be used in the research of herpetic keratoconjunctivitis, herpes simplex encephalitis, herpetic uveitis, and chronic active hepatitis associated with hepatitis B virus .
    Vidarabine monohydrate
  • HY-14941
    Elacytarabine
    1 Publications Verification

    CP 4055

    		 Nucleoside Antimetabolite/Analog Cancer
    Elacytarabine (CP 4055) is a lipid-conjugated derivative of the nucleoside analog cytarabine. Elacytarabine (CP 4055) is an antineoplastic agent with cytotoxicity in solid tumors.
    Elacytarabine
  • HY-13465
    VCH-916
    1 Publications Verification

    		 HCV Virus Protease Infection
    VCH-916 is a thiophene derivative and non-nucleoside inhibitor of HCV NS5B polymerase. VCH-916 binds to Thumb Site II. VCH-916 can be used for the research of hepatitis c virus (hcv) infection .
    VCH-916
  • HY-100028
    AT-130
    2 Publications Verification

    		 HBV DNA/RNA Synthesis Infection Cancer
    AT-130, a phenylpropenamide derivative, is a potent hepatitis B virus (HBV) replication non-nucleoside inhibitor. AT-130 inhibits the viral DNA synthesis with an EC50 of 0.13 μM. AT-130 inhibits both wt and mutant HBVs. AT-130 has anti-HBV activity in hepatoma cells .
    AT-130
  • HY-N0262R
    Cordycepin (Standard)

    3'-Deoxyadenosine (Standard)

    		 TNF Receptor Reference Standards MMP Bacterial Autophagy Antibiotic Infection Inflammation/Immunology Cancer
    Cordycepin (Standard) is the analytical standard of Cordycepin. This product is intended for research and analytical applications. Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase .
    Cordycepin (Standard)
  • HY-41344
    Ganciclovir mono-O-acetate

    		Antibiotic Infection
    Ganciclovir mono-O-acetate is a derivative of Ganciclovir. Ganciclovir, a nucleoside analogue, is an orally active antiviral agent with activity against CMV .
    Ganciclovir mono-O-acetate
  • HY-W001957
    Glurate

    4-Acetylbutyric acid; 5-Oxohexanoic acid; NSC-5281

    		 Drug Intermediate HIV Infection
    Glurate (4-Acetylbutyric acid) is an acylating agent. Glurate can be used in the development of antiviral compounds, especially those targeting retroviruses such as herpes virus and HIV. Glurate can be used in the synthesis of acyclic nucleoside derivatives and 5-hydroxyhexanoic acid .
    Glurate
  • HY-W054064
    6-Chloro-7-deazapurine-β-D-riboside

    		Fungal Infection
    6-Chloro-7-deazapurine-β-D-riboside, a nucleoside derivative, exerts antifungal effects. 6-Chloro-7-deazapurine-β-D-riboside shows activity against plant pathogenic fungi .
    6-Chloro-7-deazapurine-β-D-riboside
  • HY-W008388
    Bz-rA

    N6-Benzoyladenosine

    		 Nucleoside Antimetabolite/Analog Others
    Bz-rA (N6-Benzoyladenosine) is a nucleoside derivative with an N6 protecting group. Bz-rA is mainly used as a synthetic intermediate to participate in photocatalytic oxidative cyclization reactions and synthesize oligoribonucleotides. Bz-rA can be used to efficiently construct heterocyclic skeletons in photochemical conversions and protect the ribose moiety to regulate the cyclization pathway .
    Bz-rA
  • HY-111807
    Locked nucleic acid 1

    		Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Metabolic Disease
    Locked nucleic acid 1 is a derivative of LNA-type nucleoside.
    Locked nucleic acid 1
  • HY-W586082
    N-Isobutyryl-2', 3'-acetyl-guanosine

    		Nucleoside Antimetabolite/Analog Others
    N-Isobutyryl-2',3'-Acetyl-Guanosine is a guanosine nucleoside derivative.
    N-Isobutyryl-2', 3'-acetyl-guanosine
  • HY-W073825
    N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine

    		Nucleoside Antimetabolite/Analog Cancer
    N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine is a 2’-0-(2-methoxyethyl) guanosine derivative. 2’-0-methoxyethyl nucleoside derivatives can enhance the affinity with RNA and increase the resistance of oligonucleotides to nucleases.
    N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine
  • HY-177747
    dMeThPmR

    		Nucleoside Transporters Cancer
    dMeThPmR, a ribonucleoside derivative, is a potent and selective human nucleoside transporter 1 (hCNT1) inhibitor (Ki = 0.3-0.98 μM). dMeThPmR exhibit weak inhibitory activity on hCNT2 (IC50 = 133 μM) and hCNT3 (Ki = 32.7 μM). dMeThPmR can protect cells from the toxicity of nucleoside drugs. dMeThPmR can be used for the research of cancer .
    dMeThPmR
  • HY-177746
    MeThPmR

    		Nucleoside Transporters Cancer
    MeThPmR, a ribonucleoside derivative, is a potent and selective human nucleoside transporter 1 (hCNT1) inhibitor (Ki/sub> = 0.16-0.69 μM). MeThPmR exhibit weak inhibitory activity on hCNT2 (IC50 = 360 μM) and hCNT3 (Ki = 4.7 μM). MeThPmR can protect cells from the toxicity of nucleoside drugs. MeThPmR can be used for the research of cancer .
    MeThPmR
  • HY-153062
    6-Chloro-7-deazapurine-2F-β-D-arabinofuranose

    		HCV Infection
    6-Chloro-7-deazapurine-2F-β-D-arabinofuranose is a nucleoside derivative. 6-Chloro-7-deazapurine-2F-β-D-arabinofuranose can be used for synthesis of antiviral agent against hepatitis C virus infection .
    6-Chloro-7-deazapurine-2F-β-D-arabinofuranose
  • HY-111642
    3'-Azido-3'-deoxy-beta-L-uridine

    		Nucleoside Antimetabolite/Analog Others
    3'-Azido-3'-deoxy-beta-L-uridine (Compound 25) is a nucleoside derivative. 3'-Azido-3'-deoxy-beta-L-uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    3'-Azido-3'-deoxy-beta-L-uridine
  • HY-15350
    Trovirdine hydrochloride

    LY 300046 hydrochloride

    		 Reverse Transcriptase Others
    Trovirdine hydrochloride, a phenethylthiazolylthiourea (PETT) derivative, is an HIV reverse transcriptase (RT) non-nucleoside inhibitor (NNI). A novel computer model of the RT/NNI binding pocket revealed spatial gaps around Trovirdine hydrochloride's pyridyl ring. Docking studies suggested that replacing this planar ring with a nonplanar piperidinyl or piperazinyl ring could better occupy the binding pocket, enhancing anti-HIV activity. Synthesized heterocyclic compounds based on this modification demonstrated greater potency than Trovirdine hydrochloride, effectively inhibiting HIV replication at nanomolar concentrations without cytotoxicity in infected peripheral blood mononuclear cells .
    Trovirdine hydrochloride
  • HY-172003
    Isoorotidine

    		Nucleoside Antimetabolite/Analog Metabolic Disease
    Isoorotidine is a nucleoside derivative and an isomer of the pyrimidine nucleoside Orotidine (HY-113226).
    Isoorotidine
  • HY-155291
    3'-Mant-GDP

    		Others Others
    3'-Mant-GDP is a nucleoside compound and a derivative of guanosine diphosphate .
    3'-Mant-GDP
  • HY-137693
    ddTTPαS

    		Nucleoside Antimetabolite/Analog Others
    ddTTPαS is a sulfur-containing nucleoside triphosphate derivative. ddTTPαS can be used for chain extension in PCR assays .
    ddTTPαS
  • HY-137693A
    ddTTPαS tetrasodium

    		Nucleoside Antimetabolite/Analog Others
    ddTTPαS tetrasodium is a sulfur-containing nucleoside triphosphate derivative. ddTTPαS tetrasodium can be used for chain extension in PCR assays .
    ddTTPαS tetrasodium
  • HY-152294
    3′-Deoxy-3′-methyluridine

    		DNA/RNA Synthesis Infection
    3′-Deoxy-3′-methyluridine is a nucleoside derivative, involving in preparation inhibitors of RNA-dependent RNA viral polymerase .
    3′-Deoxy-3′-methyluridine
  • HY-159737
    Rociclovir

    HOE 602

    		 HCV CMV Infection
    Rociclovir (HOE 602) is an acyclic nucleoside derivative. Rociclovir protects mice against HSV and MCMV infections, but lacks antiviral activity in cell cultures .
    Rociclovir
  • HY-172027
    Remdesivir methylpropyl ester analog

    GS-5734 methylpropyl ester analog

    		 SARS-CoV Infection
    Remdesivir methylpropyl ester analog (GS-5734 methylpropyl ester analog) is a derivative of Remdesivir (HY-104077). Remdesivir is a nucleoside analogue with effective antiviral activity.
    Remdesivir methylpropyl ester analog
  • HY-138594
    5'-O-TBDMS-N2-ibu-dG

    		DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Infection Cancer
    5'-O-TBDMS-N2-ibu-dG is a nucleoside derivative and can be used for lead compounds synthesis with anti-bovine viral diarrhea virus activity .
    5'-O-TBDMS-N2-ibu-dG
  • HY-W048502
    8-Mercaptoadenosine

    8-Thioadenosine

    		 Drug Intermediate Others
    8-Mercaptoadenosine is a nucleoside derivative that can be synthesized in DMF-aqueous solution at room temperature using NaSH via the corresponding 8-bromo compounds, and it is an intermediate in the synthesis of the substrate for RNA pyrophosphorylase .
    8-Mercaptoadenosine
  • HY-134272A
    8-Bromo-2'-deoxy-ATP tetrasodium

    8-Bromo-dATP tetrasodium

    		 Endogenous Metabolite Metabolic Disease
    8-Bromo-2'-deoxy-ATP (8-Bromo-dATP) tetrasodium is a derivative of the nucleoside triphosphate 2'-Deoxyadenosine-5'-triphosphate (dATP, HY-136648).
    8-Bromo-2'-deoxy-ATP tetrasodium
  • HY-131804A
    3'-O-Acetyl-2'-deoxycytidine-5'-O-triphosphate tetrasodium

    3'-O-Ac-dCTP tetrasodium

    		 Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Others
    3'-O-Acetyl-2'-deoxycytidine-5'-O-triphosphate (3'-O-Ac-dCTP) tetrasodium is a nucleoside triphosphate derivative with potential applications in DNA synthesis and nucleoside drug design. 3'-O-Acetyl-2'-deoxycytidine-5'-O-triphosphate tetrasodium can be used to inhibit chain elongation reactions and as a terminator or biochemical probe .
    3'-O-Acetyl-2'-deoxycytidine-5'-O-triphosphate tetrasodium
  • HY-41344R
    Ganciclovir mono-O-acetate (Standard)

    		Antibiotic Reference Standards Infection
    Ganciclovir mono-O-acetate (Standard) is the analytical standard of Ganciclovir mono-O-acetate. This product is intended for research and analytical applications. Ganciclovir mono-O-acetate is a derivative of Ganciclovir. Ganciclovir, a nucleoside analogue, is an orally active antiviral agent with activity against CMV[1].
    Ganciclovir mono-O-acetate (Standard)
  • HY-W751961
    2'-Deoxyadenosine-15N5

    		Isotope-Labeled Compounds Endogenous Metabolite Others
    2'-Deoxyadenosine-15N5 is the 15N5-labeled version of 2'-Deoxyadenosine (HY-W040329). 2'-Deoxyadenosine is a nucleoside adenosine derivative that can pair with deoxythymidine in double-stranded DNA.
    2'-Deoxyadenosine-15N5
  • HY-13465A
    VCH-916 free base

    		HCV Virus Protease Infection
    VCH-916 free base is a thiophene derivative and non-nucleoside inhibitor of HCV NS5B polymerase. VCH-916 free base binds to Thumb Site II. VCH-916 free base can be used for the research of hepatitis c virus (hcv) infection .
    VCH-916 free base
  • HY-W747965
    8-Bromoguanosine-13C2,15N

    		Isotope-Labeled Compounds Nucleoside Antimetabolite/Analog Others
    8-Bromoguanosine- 13C2, 15N is the 13C- and 15N-labeled 8-Bromoguanosine (HY-W019033). 8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function .
    8-Bromoguanosine-13C2,15N
  • HY-W767371
    8-Bromoguanosine-13C,15N2

    		Isotope-Labeled Compounds Nucleoside Antimetabolite/Analog Others
    8-Bromoguanosine- 13C, 15N2 is the 13C- and 15N-labeled 8-Bromoguanosine (HY-W019033). 8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function .
    8-Bromoguanosine-13C,15N2
  • HY-W001957R
    Glurate (Standard)

    4-Acetylbutyric acid (Standard); 5-Oxohexanoic acid (Standard); NSC-5281 (Standard)

    		 Reference Standards Drug Intermediate HIV Infection
    Glurate (Standard) is the analytical standard of Glurate (HY-W001957). This product is used for research and analytical applications. Glurate (4-Acetylbutyric acid) is an acylating agent. Glurate can be used in the development of antiviral compounds, especially those targeting retroviruses such as herpes virus and HIV. Glurate can be used in the synthesis of acyclic nucleoside derivatives and 5-hydroxyhexanoic acid .
    Glurate (Standard)
  • HY-163978
    YGZ-331

    		Adenosine Receptor Neurological Disease
    YGZ-331 is a sedative with a calming effect. YGZ-331 is a derivative of the adenosine nucleoside NGBA, which can increase GABA levels. YGZ-331 exerts a sedative-hypnotic effect by activating A1R and A2aR, and inhibiting CaMKII phosphorylation (pCaMKII) levels. YGZ-331 can reduce the spontaneous motor activity of mice .
    YGZ-331
  • HY-W701362
    Glurate-d5

    4-Acetylbutyric acid-d5; 5-Oxohexanoic acid-d5; NSC-5281-d5

    		 Isotope-Labeled Compounds HIV Drug Intermediate Infection
    Glurate-d5 (4-Acetylbutyric acid-d5; 5-Oxohexanoic acid-d5; NSC-5281-d5) is the deuterium labeled Glurate (HY-W001957). Glurate (4-Acetylbutyric acid) is an acylating agent. Glurate can be used in the development of antiviral compounds, especially those targeting retroviruses such as herpes virus and HIV. Glurate can be used in the synthesis of acyclic nucleoside derivatives and 5-hydroxyhexanoic acid .
    Glurate-d5
  • HY-W013403S
    2'-Deoxy-2'-fluorouridine-d2

    		IFNAR Infection
    2'-Deoxy-2'-fluorouridine-d2 is the deuterium labeled 2'-Deoxy-2'-fluorouridine . 2'-Deoxy-2'-fluorouridine is a derivative of the pyrimidine nucleoside uridine. 2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. Hepatitis C polyU/UC RNA strands containing 2'-Deoxy-2'-fluorouridine, bind to RIG-I but do not activate RIG-I signaling in a reporter assay using Huh7 cells. 2'-Deoxy-2'-fluorouridine also has been used as a starting material in the synthesis of respiratory syncytial virus (RSV) polymerase inhibitors. 2'-Deoxy-2'-fluorouridine can incorporate into DNA and RNA in rat and woodchuck model upon administration. 2'-Deoxy-2'-fluorouridine can be studied in anti-viral research .
    2'-Deoxy-2'-fluorouridine-d2
  • HY-131805A
    3'-O-Ac-dGTP sodium

    		Drug Derivative Metabolic Disease
    3'-O-Ac-dGTP sodium is an acetylated derivative of the nucleoside triphosphate 2'-deoxyguanosine-5'-triphosphate .
    3'-O-Ac-dGTP sodium
  • HY-183641
    5'-O-DMTr-N,N-Dimethylacetamide-dA-3'-CE phosphoramidite

    		Phosphoramidites DNA/RNA Synthesis Others
    5'-O-DMTr-N,N-Dimethylacetamide-dA-3'-CE phosphoramidite is a Phosphoramidite derivative. 5'-O-DMTr-N,N-Dimethylacetamide-dA-3'-CE phosphoramidite can be used in studies related to the introduction of N-alkyl nucleosides into DNA oligonucleotides .
    5'-O-DMTr-N,N-Dimethylacetamide-dA-3'-CE phosphoramidite

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