Staurosporine  (Synonyms: Antibiotic AM-2282; STS; AM-2282)

Staurosporine (AM-2282) (GMP) is Staurosporine (HY-15141) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases^{[1][2][3][4][5]}.

Staurosporine (GMP) (316 nM; 24 h) induces the production of robust neurite in RGC-5 cells^[1].
Staurosporine (GMP) (25 and 100 nM; 12 h) induces differentiation of SH-SY5Y cells with the increasing of neurite processes combined with a prominent branching and the subsequent reduction in cell body size^[2].
Staurosporine (GMP) (20 nM) induces cell differentiation of human neuroblastoma cell line^[3].
Staurosporine (GMP) (5 nM) enhances HL-60-cell differentiation induced by 1 alpha,25 dihydroxyvitamin D3, dbc AMP, all-trans-beta-retinoic acid (RA), actinomycin D (Act D) and other compounds^[4].
Staurosporine (GMP) (1 μM; 15 d) induces differentiation of human neuroblastoma cells^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

466.53

C₂₈H₂₆N₄O₃

62996-74-1

O=C(NC1)C2=C1C3=C(C4=C2C5=C(C=CC=C5)N4[C@H]6C[C@@H](NC)[C@@H](OC)[C@]7(C)O6)N7C8=CC=CC=C83

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ganapathy PS, et al. Sensitivity of staurosporine-induced differentiated RGC-5 cells to homocysteine. Curr Eye Res. 2010 Jan;35(1):80-90.  [Content Brief]

  [2]. Pregi N, et al. Effect of erythropoietin on staurosporine-induced apoptosis and differentiation of SH-SY5Y neuroblastoma cells. Biochim Biophys Acta. 2006 Feb;1763(2):238-46.  [Content Brief]

  [3]. Hajimu MORIOKA, et al. Staurosporine-induced Differentiation in a Human Neuroblastoma Cell Line, NB-1. Agricultural and Biological Chemistry. 1985; 1959-1963.

  [4]. Okazaki T, et al. Staurosporine, a novel protein kinase inhibitor, enhances HL-60-cell differentiation induced by various compounds. Exp Hematol. 1988 Jan;16(1):42-8.  [Content Brief]

  [5]. Yuste VJ, et al. The prevention of the staurosporine-induced apoptosis by Bcl-X(L), but not by Bcl-2 or caspase inhibitors, allows the extensive differentiation of human neuroblastoma cells. J Neurochem. 2002 Jan;80(1):126-39.  [Content Brief]