Cat. No.: HY-15141G

Staurosporine (GMP)

Name: Staurosporine (GMP)
Brand: MedChemExpress
SKU: HY-15141G
Price: 1380.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Antibiotic AM-2282 (GMP); STS (GMP); AM-2282 (GMP))

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Staurosporine (AM-2282) (GMP) is Staurosporine (HY-15141) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases.

For research use only. We do not sell to patients.

CAS No.: 62996-74-1
Formula: C₂₈H₂₆N₄O₃
Molecular Weight:466.53

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Please store the product under the recommended conditions in the Certificate of Analysis.

Staurosporine (GMP) Chemical Structure

CAS No.: 62996-74-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Biological Activity

Description

All PKC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
518A2	IC₅₀	0.2 μM Compound: STP	Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay	[PMID: 24361521]
518A2	EC₅₀	0.03 μM Compound: STS	Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay	[PMID: 29197730]
8505C	IC₅₀	0.2 μM Compound: STP	Cytotoxicity against human 8505C cells after 96 hrs by SRB assay Cytotoxicity against human 8505C cells after 96 hrs by SRB assay	[PMID: 24361521]
A2780	IC₅₀	0.2 μM Compound: STP	Cytotoxicity against human A2780 cells after 96 hrs by SRB assay Cytotoxicity against human A2780 cells after 96 hrs by SRB assay	[PMID: 24361521]
A2780	EC₅₀	0.12 μM Compound: STS	Cytotoxicity against human A2780 cells after 96 hrs by SRB assay Cytotoxicity against human A2780 cells after 96 hrs by SRB assay	[PMID: 29197730]
A2780	EC₅₀	0.1 μM Compound: STS	Cytotoxicity against human A2780 cells assessed as reduction in cell viability after 96 hrs by SRB assay Cytotoxicity against human A2780 cells assessed as reduction in cell viability after 96 hrs by SRB assay	[PMID: 30840925]
A2780	IC₅₀	0.1 μM Compound: ST	Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 32422522]
A2780	EC₅₀	0.1 μM Compound: Staurosporine	Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay	[PMID: 33049606]
A-375	IC₅₀	2.1 μM Compound: Staurosporine	Antiproliferative activity against human A-375 cells assessed as reduction in cell viability measured after 48 hrs by colorimetric based MTT assay Antiproliferative activity against human A-375 cells assessed as reduction in cell viability measured after 48 hrs by colorimetric based MTT assay	[PMID: 35196017]
A-431	IC₅₀	70 nM Compound: Staurosporine	Cytotoxicity against human A431 cells after 24 hrs using Annexin VeFITC/propidium iodide staining by MTT assay Cytotoxicity against human A431 cells after 24 hrs using Annexin VeFITC/propidium iodide staining by MTT assay	[PMID: 22541051]
A549	GI₅₀	2.4 nM Compound: staurosporine	Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B method Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B method	[PMID: 18484775]
A549	IC₅₀	139.95 ng/mL Compound: Staurosporine	Cytotoxicity against human A549 cells after 24 hrs by propidium iodide assay Cytotoxicity against human A549 cells after 24 hrs by propidium iodide assay	[PMID: 19138858]
A549	IC₅₀	139.95 ng/mL Compound: Staurosporine	Cytotoxicity against human A549 cells after 24 hrs by YO-PRO-1 assay Cytotoxicity against human A549 cells after 24 hrs by YO-PRO-1 assay	[PMID: 19138858]
A549	IC₅₀	0.6 μM Compound: STP	Cytotoxicity against human A549 cells after 96 hrs by SRB assay Cytotoxicity against human A549 cells after 96 hrs by SRB assay	[PMID: 24361521]
A549	IC₅₀	3.05 μM Compound: Staurosporine	Antiproliferative activity against human A549 cells after 24 to 48 hrs by CCK-8 assay Antiproliferative activity against human A549 cells after 24 to 48 hrs by CCK-8 assay	[PMID: 24792811]
A549	IC₅₀	0.02 μM Compound: staurosporine	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 25825934]
A549	EC₅₀	0.04 μM Compound: STS	Cytotoxicity against human A549 cells after 96 hrs by SRB assay Cytotoxicity against human A549 cells after 96 hrs by SRB assay	[PMID: 29197730]
A549	IC₅₀	13.22 μM Compound: Staurosporine	Antiproliferative activity against human A549 cells measured after 72 hrs under CoCl2-induced hypoxic condition by MTT assay Antiproliferative activity against human A549 cells measured after 72 hrs under CoCl2-induced hypoxic condition by MTT assay	[PMID: 31794211]
A549	IC₅₀	7.47 μM Compound: Staurosporine	Antiproliferative activity against human A549 cells measured after 72 hrs under normoxic condition by MTT assay Antiproliferative activity against human A549 cells measured after 72 hrs under normoxic condition by MTT assay	[PMID: 31794211]
A549	IC₅₀	9.5 μM Compound: Staurosporine	Cytotoxicity against human A549 cells assessed as cell viability measured by MTT assay Cytotoxicity against human A549 cells assessed as cell viability measured by MTT assay	[PMID: 34246754]
A549	IC₅₀	9.1 μM Compound: Staurosporine	Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by colorimetric based MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by colorimetric based MTT assay	[PMID: 35196017]
A549	IC₅₀	0.002 μM Compound: Staurosporine	Anticancer activity against human A549 cells harboring KRAS mutant assessed as inhibition of cell growth Anticancer activity against human A549 cells harboring KRAS mutant assessed as inhibition of cell growth	[PMID: 38199330]
A549	IC₅₀	0.02 μM Compound: Staurosporine	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	10.1039/C2MD20098H
A549	IC₅₀	0.02 μmol Compound: Staurosporine	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	10.1039/C2MD20098H
B16-F10	IC₅₀	2.82 μM Compound: Staurosporine	Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay Antiproliferative activity against mouse B16F10 cells after 48 hrs by MTT assay	[PMID: 22503364]
BGC-823	EC₅₀	26.83 μg/mL Compound: Staurosporine	Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay	[PMID: 21889345]
BGC-823	IC₅₀	6.83 μM Compound: Staurosporine	Antiproliferative activity against human BGC823 cells after 48 hrs by MTT method Antiproliferative activity against human BGC823 cells after 48 hrs by MTT method	[PMID: 23018096]
BGC-823	IC₅₀	0.38 μM Compound: Staurosporine	Cytotoxicity against human BGC823 cells after 72 hrs by CellTitre-Glo luminescent cell viability assay Cytotoxicity against human BGC823 cells after 72 hrs by CellTitre-Glo luminescent cell viability assay	[PMID: 24328283]
BJ	IC₅₀	0.002 μM Compound: Staurosporine	Cytotoxicity against human BJ cells after 72 hrs by Calcein AM assay Cytotoxicity against human BJ cells after 72 hrs by Calcein AM assay	[PMID: 22921081]
BJ	EC₅₀	<2 μM Compound: Staurosporine	Cytotoxicity against human BJ cells Cytotoxicity against human BJ cells	[PMID: 25316317]
BJ	EC₅₀	>40 μM Compound: STS	Antiproliferative activity against human BJ cells after 72 hrs by CellTiter-Glo luminescent cell viability assay Antiproliferative activity against human BJ cells after 72 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 30840453]
BT-549	IC₅₀	0.08 μM Compound: Staurosporine	Cytotoxic activity against human BT549 cells incubated for 24 hrs by MTT assay Cytotoxic activity against human BT549 cells incubated for 24 hrs by MTT assay	[PMID: 28705432]
CAPAN-1	IC₅₀	0.66 μM Compound: Staurosporine	Cytostatic activity against human Capan1 cells Cytostatic activity against human Capan1 cells	[PMID: 30738653]
CAPAN-1	IC₅₀	0.048 μM Compound: Staurosporine	Antiproliferative activity against human Capan1 cells Antiproliferative activity against human Capan1 cells	[PMID: 31005446]
CAPAN-1	IC₅₀	0.03 μM Compound: STS	Antiproliferative activity against human Capan1 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging assay Antiproliferative activity against human Capan1 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging assay	[PMID: 32832030]
CAPAN-1	IC₅₀	0.0123 μM Compound: Staurosporine	Antiproliferative activity against human CAPAN-1 cells assessed as inhibition of cell proliferation measured after 72 hrs by by real time imaging analysis Antiproliferative activity against human CAPAN-1 cells assessed as inhibition of cell proliferation measured after 72 hrs by by real time imaging analysis	[PMID: 33248847]
CAPAN-1	IC₅₀	0.0546 μM Compound: Staurosporine	Antiproliferative activity against human CAPAN-1 cells assessed as inhibition of cell viability measured after 72 hrs by colorimetric MTS viability assay Antiproliferative activity against human CAPAN-1 cells assessed as inhibition of cell viability measured after 72 hrs by colorimetric MTS viability assay	[PMID: 34352711]
Ca-Ski	IC₅₀	0.01144 μM Compound: Staurosporine	Antiproliferative activity against human Ca-Ski cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay Antiproliferative activity against human Ca-Ski cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 34656041]
CCRF-CEM	IC₅₀	0.023 μM Compound: Staurosporine	Cytotoxicity against human CEM cells after 72 hrs by Calcein AM assay Cytotoxicity against human CEM cells after 72 hrs by Calcein AM assay	[PMID: 22921081]
CHO-K1	GI₅₀	0.13 μM Compound: Staurosporine	Cytotoxicity against human CHOK1 cells after 48 hrs by SRB assay Cytotoxicity against human CHOK1 cells after 48 hrs by SRB assay	[PMID: 21513294]
COLO 205	IC₅₀	<0.1 μM Compound: Staurosporine	Antiproliferative activity against human COLO205 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human COLO205 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 31740249]
DLD-1	IC₅₀	0.009 μM Compound: Staurosporine	Antiproliferative activity against human colon cancer cell line (DLD-1 cells) using MTT assay Antiproliferative activity against human colon cancer cell line (DLD-1 cells) using MTT assay	[PMID: 11591505]
DLD-1	IC₅₀	0.009 μM Compound: Staurosporine	Antiproliferative activity against human DLD1 cells after 48 to 72 hrs by MTT assay Antiproliferative activity against human DLD1 cells after 48 to 72 hrs by MTT assay	[PMID: 22182929]
DU-145	IC₅₀	0.5 μM Compound: Staurosporine	Induction of mitochondrial membrane potential loss in human DU145 cells after 2 hrs by JC1 staining based fluorescence assay Induction of mitochondrial membrane potential loss in human DU145 cells after 2 hrs by JC1 staining based fluorescence assay	[PMID: 31120251]
FaDu	EC₅₀	0.2 μM Compound: STS	Cytotoxicity against human FADU cells assessed as reduction in cell viability after 96 hrs by SRB assay Cytotoxicity against human FADU cells assessed as reduction in cell viability after 96 hrs by SRB assay	[PMID: 30840925]
FaDu	IC₅₀	0.1 μM Compound: ST	Cytotoxicity against human FaDu cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Cytotoxicity against human FaDu cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 32422522]
FaDu	EC₅₀	0.1 μM Compound: Staurosporine	Cytotoxicity against human FaDu cells assessed as reduction in cell viability measured after 72 hrs by SRB assay Cytotoxicity against human FaDu cells assessed as reduction in cell viability measured after 72 hrs by SRB assay	[PMID: 33049606]
FHC	GI₅₀	32.65 μM Compound: Staurosporine	Cytotoxicity against human FHC cells assessed as cell growth inhibition incubated for 4 days by MTT assay Cytotoxicity against human FHC cells assessed as cell growth inhibition incubated for 4 days by MTT assay	[PMID: 37506545]
HaCaT	IC₅₀	1.6 μM Compound: Staurosporine	Antiproliferative activity against human HaCaT cells assessed as reduction in cell viability measured after 48 hrs by colorimetric based MTT assay Antiproliferative activity against human HaCaT cells assessed as reduction in cell viability measured after 48 hrs by colorimetric based MTT assay	[PMID: 35196017]
HCT-116	IC₅₀	0.006 μM Compound: Staurosporine	Concentration required for growth inhibition of human colon carcinoma cell line HCT116 Concentration required for growth inhibition of human colon carcinoma cell line HCT116	[PMID: 15537345]
HCT-116	IC₅₀	39 nM Compound: Staurosporine	Inhibition of TNIK-mediated TCF4/beta-casein transcription in human HCT116 cells by beta-lactamase reporter gene assay Inhibition of TNIK-mediated TCF4/beta-casein transcription in human HCT116 cells by beta-lactamase reporter gene assay	[PMID: 23232060]
HCT-116	IC₅₀	0.055 μM Compound: Staurosporine	Cytotoxicity against human HCT116 cells by sulforhodamine B assay Cytotoxicity against human HCT116 cells by sulforhodamine B assay	[PMID: 29389122]
HCT-116	IC₅₀	0.03 μM Compound: Staurosporine	Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 30106291]
HCT-116	IC₅₀	0.037 μM Compound: Staurosporine	Antiproliferative activity against human HCT116 cells Antiproliferative activity against human HCT116 cells	[PMID: 31005446]
HCT-116	IC₅₀	<0.1 μM Compound: Staurosporine	Antiproliferative activity against human HCT116 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 31740249]
HCT-116	IC₅₀	16.15 μM Compound: Staurosporine	Antiproliferative activity against human HCT116 cells measured after 72 hrs under CoCl2-induced hypoxic condition by MTT assay Antiproliferative activity against human HCT116 cells measured after 72 hrs under CoCl2-induced hypoxic condition by MTT assay	[PMID: 31794211]
HCT-116	IC₅₀	8.86 μM Compound: Staurosporine	Antiproliferative activity against human HCT116 cells measured after 72 hrs under normoxic condition by MTT assay Antiproliferative activity against human HCT116 cells measured after 72 hrs under normoxic condition by MTT assay	[PMID: 31794211]
HCT-116	IC₅₀	0.04 μM Compound: STS	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging assay	[PMID: 32832030]
HCT-116	IC₅₀	0.0281 μM Compound: Staurosporine	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 72 hrs by by real time imaging analysis Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 72 hrs by by real time imaging analysis	[PMID: 33248847]
HCT-116	IC₅₀	0.0481 μM Compound: Staurosporine	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell viability measured after 72 hrs by colorimetric MTS viability assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell viability measured after 72 hrs by colorimetric MTS viability assay	[PMID: 34352711]
HCT-116	IC₅₀	6.94 μM Compound: Staurosporine	Anticancer activity against human HCT-116 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Anticancer activity against human HCT-116 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 35694689]
HCT-116	IC₅₀	32.57 μg/mL Compound: Staurosporine	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin dye based assay	[PMID: 37224699]
HCT-116	GI₅₀	6.31 μM Compound: Staurosporine	Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 4 days by MTT assay Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 4 days by MTT assay	[PMID: 37506545]
HCT-116	IC₅₀	13.2 μM Compound: Staurosporine	Antiproliferative activity against Homo sapiens (human) HCT116 cells assessed as growth inhibition after 48 hr by MTT assay Antiproliferative activity against Homo sapiens (human) HCT116 cells assessed as growth inhibition after 48 hr by MTT assay	10.1007/s00044-012-0306-5
HEK293	IC₅₀	0.077 μM Compound: staurosporine	Inhibition of PKC-beta II mediated IL-8 release from HEK293 cells by ELISA Inhibition of PKC-beta II mediated IL-8 release from HEK293 cells by ELISA	[PMID: 12941331]
HEK293	IC₅₀	0.077 μM Compound: Staurosporine	Inhibition of IL-8 release by HEK293 cells expressing PKC-beta2 Inhibition of IL-8 release by HEK293 cells expressing PKC-beta2	[PMID: 15771419]
HEK293	IC₅₀	0.056 μM Compound: Staurosporine	Cytotoxicity against HEK293 cells after 72 hrs by CellTiterGlo assay Cytotoxicity against HEK293 cells after 72 hrs by CellTiterGlo assay	[PMID: 24763262]
HEK293	EC₅₀	<2 μM Compound: Staurosporine	Cytotoxicity against HEK293 cells Cytotoxicity against HEK293 cells	[PMID: 25316317]
HEK293	CC₅₀	0.00354 μM Compound: Staurosporine	Cytotoxicity against HEK293 cells assessed as decrease in cell viability after 72 hrs by CellTiter Glo luminescent assay Cytotoxicity against HEK293 cells assessed as decrease in cell viability after 72 hrs by CellTiter Glo luminescent assay	[PMID: 28624701]
HEK293	IC₅₀	0.0037 μM Compound: Staurosporine	Cytotoxicity against human HEK293 cells assessed as cell viability incubated for 72 hrs by cell titer-glo luminescent cell viability assay (Rvb = > 100 uM) Cytotoxicity against human HEK293 cells assessed as cell viability incubated for 72 hrs by cell titer-glo luminescent cell viability assay (Rvb = > 100 uM)	[PMID: 31252285]
HEK293	IC₅₀	0.41 μM Compound: Staurosporine	Antiproliferative activity against HEK293 cells assessed as inhibition rate incubated for 72 hrs by MTT assay Antiproliferative activity against HEK293 cells assessed as inhibition rate incubated for 72 hrs by MTT assay	[PMID: 34844412]
HEK293	IC₅₀	34.33 μM Compound: Staurosporine	Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability by MTT assay Cytotoxicity against human HEK293 cells assessed as inhibition of cell viability by MTT assay	[PMID: 35182815]
HEK293	GI₅₀	9.25 μM Compound: Staurosporine	Cytotoxicity against human HEK293 cells assessed as cell growth inhibition incubated for 4 days by MTT assay Cytotoxicity against human HEK293 cells assessed as cell growth inhibition incubated for 4 days by MTT assay	[PMID: 37506545]
HeLa	IC₅₀	4 pM Compound: Staurosporine	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 21388191]
HeLa	IC₅₀	4 pM Compound: Staurosporine	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 21488655]
HeLa	EC₅₀	29.12 μg/mL Compound: Staurosporine	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 21889345]
HeLa	IC₅₀	0.175 μM Compound: Staurosporine	Cytotoxicity against human HeLa cells after 72 hrs by Calcein AM assay Cytotoxicity against human HeLa cells after 72 hrs by Calcein AM assay	[PMID: 22921081]
HeLa	IC₅₀	9.12 μM Compound: Staurosporine	Antiproliferative activity against human HeLa cells after 48 hrs by MTT method Antiproliferative activity against human HeLa cells after 48 hrs by MTT method	[PMID: 23018096]
HeLa	IC₅₀	2.72 μM Compound: Staurosporine	Antiproliferative activity against human HeLa cells after 24 to 48 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells after 24 to 48 hrs by CCK-8 assay	[PMID: 24792811]
HeLa	IC₅₀	0.025 μM Compound: staurosporine	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 25825934]
HeLa	IC₅₀	0.025 μM Compound: Staurosporine	Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay	10.1039/C2MD20098H
HeLa	IC₅₀	0.025 μmol Compound: Staurosporine	Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay	10.1039/C2MD20098H
HeLa S3	IC₅₀	4 pM Compound: Staurosporine	Cytotoxicity against human HeLa S3 cells measured after 72 hrs Cytotoxicity against human HeLa S3 cells measured after 72 hrs	[PMID: 32688198]
HepG2	EC₅₀	21.74 μg/mL Compound: Staurosporine	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 21889345]
HepG2	IC₅₀	4.14 μM Compound: Staurosporine	Inhibition of telomerase in human HepG2 cells after 24 hrs by TRAP-PCR-ELISA assay Inhibition of telomerase in human HepG2 cells after 24 hrs by TRAP-PCR-ELISA assay	[PMID: 23018096]
HepG2	IC₅₀	6.73 μM Compound: Staurosporine	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT method Antiproliferative activity against human HepG2 cells after 48 hrs by MTT method	[PMID: 23018096]
HepG2	IC₅₀	8.3 μM Compound: Staurosporine	Inhibition of telomerase in human HepG2 cells after 48 hrs by TRAP-PCR-ELISA Inhibition of telomerase in human HepG2 cells after 48 hrs by TRAP-PCR-ELISA	[PMID: 23279864]
HepG2	EC₅₀	<2 μM Compound: Staurosporine	Cytotoxicity against human HepG2 cells Cytotoxicity against human HepG2 cells	[PMID: 25316317]
HepG2	IC₅₀	0.018 μM Compound: Staurosporine	Cytotoxicity against human HepG2 cells at 100 uM after 3 days by CellTiter-Glo luminescent cell viability assay Cytotoxicity against human HepG2 cells at 100 uM after 3 days by CellTiter-Glo luminescent cell viability assay	[PMID: 28993106]
HepG2	IC₅₀	5.07 μM Compound: Staurosporine	Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36848846]
HepG2	IC₅₀	9.04 μM Compound: Staurosporine	Antiproliferative activity against Homo sapiens (human) HepG2 cells assessed as growth inhibition after 48 hr by MTT assay Antiproliferative activity against Homo sapiens (human) HepG2 cells assessed as growth inhibition after 48 hr by MTT assay	10.1007/s00044-012-0306-5
HL-60	IC₅₀	9.24 μM Compound: Staurosporine	Cytostatic activity against human HL60 cells Cytostatic activity against human HL60 cells	[PMID: 30738653]
HL-60	IC₅₀	0.019 μM Compound: Staurosporine	Antiproliferative activity against human HL60 cells Antiproliferative activity against human HL60 cells	[PMID: 31005446]
HL-60	IC₅₀	0.04 μM Compound: STS	Antiproliferative activity against human HL60 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging assay Antiproliferative activity against human HL60 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging assay	[PMID: 32832030]
HL-60	IC₅₀	0.0076 μM Compound: Staurosporine	Antiproliferative activity against human HL-60 cells assessed as inhibition of cell proliferation measured after 72 hrs by by real time imaging analysis Antiproliferative activity against human HL-60 cells assessed as inhibition of cell proliferation measured after 72 hrs by by real time imaging analysis	[PMID: 33248847]
HL-60	IC₅₀	0.041 μM Compound: Staurosporine	Antiproliferative activity against human HL-60 cells assessed as inhibition of cell viability measured after 72 hrs by real-time IncuCyte proliferation analysis Antiproliferative activity against human HL-60 cells assessed as inhibition of cell viability measured after 72 hrs by real-time IncuCyte proliferation analysis	[PMID: 34352711]
HMLE	IC₅₀	4.9 nM Compound: 1	Cytotoxicity against human HMLE cells assessed as reduction in cell metabolic activity after 72 hrs by MTS assay Cytotoxicity against human HMLE cells assessed as reduction in cell metabolic activity after 72 hrs by MTS assay	[PMID: 33335665]
HOP-92	GI₅₀	9.99 μM Compound: Staurosporine	Cytotoxicity against human HOP-92 cells assessed as cell growth inhibition incubated for 4 days by MTT assay Cytotoxicity against human HOP-92 cells assessed as cell growth inhibition incubated for 4 days by MTT assay	[PMID: 37506545]
HT-29	GI₅₀	10.9 nM Compound: staurosporine	Cytotoxicity against human HT29 cells after 72 hrs by sulforhodamine B method Cytotoxicity against human HT29 cells after 72 hrs by sulforhodamine B method	[PMID: 18484775]
HT-29	ED₅₀	2.6 nM Compound: staurosporine	Induction of apoptosis in human HT-29 cells assessed as change in mitochondrial transmembrane potential after 2 hrs by JC1 staining based fluorescence assay Induction of apoptosis in human HT-29 cells assessed as change in mitochondrial transmembrane potential after 2 hrs by JC1 staining based fluorescence assay	[PMID: 19422206]
HT-29	IC₅₀	2 nM Compound: Staurosporine	Effect on mitochondrial membrane potential in human HT-29 cells after 2 hrs using JC-1 staining by fluorescence assay Effect on mitochondrial membrane potential in human HT-29 cells after 2 hrs using JC-1 staining by fluorescence assay	[PMID: 21428375]
HT-29	IC₅₀	2.5 nM Compound: Staurosporine	Inhibition of mitochondrial membrane potential in human HT-29 cells using JC1 dye staining by fluorescence plate reader assay Inhibition of mitochondrial membrane potential in human HT-29 cells using JC1 dye staining by fluorescence plate reader assay	[PMID: 21513293]
HT-29	GI₅₀	3.6 μM Compound: Staurosporine	Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay	[PMID: 21513294]
HT-29	ED₅₀	>20 μM Compound: Staurosporine	Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay	[PMID: 21973101]
HT-29	ED₅₀	0.0026 μM Compound: Staurosporine	Induction of apoptosis in human HT-29 cells assessed reduction of mitochondrial membrane potential after 2 hrs by using JC1 staining by fluorescence cell-based assay Induction of apoptosis in human HT-29 cells assessed reduction of mitochondrial membrane potential after 2 hrs by using JC1 staining by fluorescence cell-based assay	[PMID: 21973101]
HT-29	IC₅₀	0.2 μM Compound: STP	Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay	[PMID: 24361521]
HT-29	EC₅₀	0.15 μM Compound: STS	Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay	[PMID: 29197730]
HT-29	IC₅₀	20 nM Compound: Staurosporine	Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay	[PMID: 30057155]
HT-29	EC₅₀	0.2 μM Compound: STS	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 96 hrs by SRB assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 96 hrs by SRB assay	[PMID: 30840925]
HT-29	IC₅₀	0.01 μM Compound: STS	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth	[PMID: 32201021]
HT-29	IC₅₀	0.2 μM Compound: ST	Cytotoxicity against human HT29 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Cytotoxicity against human HT29 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 32422522]
HT-29	EC₅₀	0.2 μM Compound: Staurosporine	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay	[PMID: 33049606]
Huh-7	IC₅₀	0.23 μM Compound: Staurosporine	Cytotoxicity against human HuH7 cells after 72 hrs by CellTitre-Glo luminescent cell viability assay Cytotoxicity against human HuH7 cells after 72 hrs by CellTitre-Glo luminescent cell viability assay	[PMID: 24328283]
HUVEC	IC₅₀	0.004 μM Compound: Staurosporine	Antiproliferative activity against human umbilical vein endothelial cells (HUVECs) using MTT assay Antiproliferative activity against human umbilical vein endothelial cells (HUVECs) using MTT assay	[PMID: 11591505]
HUVEC	IC₅₀	0.004 μM Compound: Staurosporine	Antiproliferative activity against human HUVEC after 48 to 72 hrs by MTT assay Antiproliferative activity against human HUVEC after 48 to 72 hrs by MTT assay	[PMID: 22182929]
HUVEC	IC₅₀	0.5 μM Compound: STS	Cytotoxicity against HUVEC cells assessed as reduction in cell viability after 96 hrs by MTT assay Cytotoxicity against HUVEC cells assessed as reduction in cell viability after 96 hrs by MTT assay	[PMID: 34671737]
Jurkat	IC₅₀	311 nM Compound: staurosporine	Antiproliferative activity against JAK3 expressing human resting Jurkat cells Antiproliferative activity against JAK3 expressing human resting Jurkat cells	[PMID: 19427203]
Jurkat	IC₅₀	71 nM Compound: staurosporine	Antiproliferative activity against JAK3 expressing IL2-stimulated human Jurkat cells Antiproliferative activity against JAK3 expressing IL2-stimulated human Jurkat cells	[PMID: 19427203]
Jurkat	IC₅₀	0.14 μM Compound: Staurosporine	Cytotoxicity against human Jurkat cells after 72 hrs by CellTitre-Glo luminescent cell viability assay Cytotoxicity against human Jurkat cells after 72 hrs by CellTitre-Glo luminescent cell viability assay	[PMID: 24328283]
Jurkat	IC₅₀	0.0393 μM Compound: Staurosporine	Cytotoxicity against human Jurkat cells assessed as inhibition of cell viability measured after 72 hrs by real-time IncuCyte proliferation analysis Cytotoxicity against human Jurkat cells assessed as inhibition of cell viability measured after 72 hrs by real-time IncuCyte proliferation analysis	[PMID: 34352711]
Jurkat	IC₅₀	3.2 μM Compound: Staurosporine	Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability measured after 48 hrs by colorimetric based MTT assay Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability measured after 48 hrs by colorimetric based MTT assay	[PMID: 35196017]
Jurkat	IC₅₀	0.003 μM Compound: Staurosporine	Inhibitory activity against protein kinase C from Jurkat cells. Inhibitory activity against protein kinase C from Jurkat cells.	10.1016/S0960-894X(01)80408-X
K562	IC₅₀	153 μM Compound: STSP	Antitumor activity against human K562 cells assessed as inhibition of cell growth after 48 hrs by MTT assay Antitumor activity against human K562 cells assessed as inhibition of cell growth after 48 hrs by MTT assay	[PMID: 26022079]
K562	IC₅₀	1.7 μM Compound: Staurosporine	Cytotoxicity against human K562 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human K562 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 30106291]
K562	IC₅₀	23.1 μM Compound: Staurosporine	Cytostatic activity against human K562 cells Cytostatic activity against human K562 cells	[PMID: 30738653]
K562	IC₅₀	0.083 μM Compound: Staurosporine	Antiproliferative activity against human K562 cells Antiproliferative activity against human K562 cells	[PMID: 31005446]
K562	IC₅₀	0.04 μM Compound: STS	Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging assay Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging assay	[PMID: 32832030]
K562	IC₅₀	0.0768 μM Compound: Staurosporine	Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation measured after 72 hrs by by real time imaging analysis Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation measured after 72 hrs by by real time imaging analysis	[PMID: 33248847]
K562	IC₅₀	>0.1 μM Compound: Staurosporine	Antiproliferative activity against human K562 cells assessed as inhibition of cell viability measured after 72 hrs by real-time IncuCyte proliferation analysis Antiproliferative activity against human K562 cells assessed as inhibition of cell viability measured after 72 hrs by real-time IncuCyte proliferation analysis	[PMID: 34352711]
KB	ED₅₀	0.0024 μg/mL Compound: 1	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 3204380]
KB 3-1	IC₅₀	<0.2 μM Compound: Staurosporine	Antiproliferative activity against human KB-3-1 cells after 5 days by WST-1 assay Antiproliferative activity against human KB-3-1 cells after 5 days by WST-1 assay	[PMID: 28956915]
KOPN-8	EC₅₀	0.71 μM Compound: STS	Antiproliferative activity against human KOPN8 cells after 72 hrs by CellTiter-Glo luminescent cell viability assay Antiproliferative activity against human KOPN8 cells after 72 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 30840453]
L02	IC₅₀	9.5 μM Compound: Staurosporine	Cytotoxicity against human LO2 cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human LO2 cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 30106291]
L929	IC₅₀	<0.2 μM Compound: Staurosporine	Antiproliferative activity against mouse L929 cells after 5 days by WST-1 assay Antiproliferative activity against mouse L929 cells after 5 days by WST-1 assay	[PMID: 28956915]
Leukemia cell	EC₅₀	0.35 μM Compound: STS	Antiproliferative activity against mouse leukemia cells overexpressing BCR/ABL after 72 hrs by CellTiter-Glo luminescent cell viability assay Antiproliferative activity against mouse leukemia cells overexpressing BCR/ABL after 72 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 30840453]
LN-229	IC₅₀	0.003 μM Compound: STS	Antiproliferative activity against human LN229 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging assay Antiproliferative activity against human LN229 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging assay	[PMID: 32832030]
LN-229	IC₅₀	0.0097 μM Compound: Staurosporine	Antiproliferative activity against human LN-229 cells assessed as inhibition of cell viability measured after 72 hrs by colorimetric MTS viability assay Antiproliferative activity against human LN-229 cells assessed as inhibition of cell viability measured after 72 hrs by colorimetric MTS viability assay	[PMID: 34352711]
LoVo	IC₅₀	0.001 μM Compound: Staurosporine	Antiproliferative activity against human colon cancer cell line (LoVo cells) using MTT assay Antiproliferative activity against human colon cancer cell line (LoVo cells) using MTT assay	[PMID: 11591505]
LoVo	IC₅₀	0.001 μM Compound: Staurosporine	Antiproliferative activity against human LoVo cells after 48 to 72 hrs by MTT assay Antiproliferative activity against human LoVo cells after 48 to 72 hrs by MTT assay	[PMID: 22182929]
LOX IMVI	IC₅₀	7.15 μM Compound: Staurosporine	Cytotoxicity against human LOX IMVI cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human LOX IMVI cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 33601311]
MCF-10A	IC₅₀	18.01 μM Compound: Staurosporine	Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38107182]
MCF7	IC₅₀	2 μM Compound: Staurosporine	Inhibition of PKA in human MCF7 cells by array-based fluorescence assay Inhibition of PKA in human MCF7 cells by array-based fluorescence assay	[PMID: 18656369]
MCF7	IC₅₀	50 nM Compound: Staurosporine	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 21388191]
MCF7	IC₅₀	50 nM Compound: Staurosporine	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 21488655]
MCF7	GI₅₀	11 μM Compound: Staurosporine	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 21513294]
MCF7	IC₅₀	3.07 μM Compound: Staurosporine	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22503364]
MCF7	IC₅₀	180 nM Compound: Staurosporine	Cytotoxicity against human MCF7 cells after 24 hrs using Annexin VeFITC/propidium iodide staining by MTT assay Cytotoxicity against human MCF7 cells after 24 hrs using Annexin VeFITC/propidium iodide staining by MTT assay	[PMID: 22541051]
MCF7	IC₅₀	0.064 μM Compound: Staurosporine	Cytotoxicity against human MCF7 cells after 72 hrs by Calcein AM assay Cytotoxicity against human MCF7 cells after 72 hrs by Calcein AM assay	[PMID: 22921081]
MCF7	IC₅₀	0.52 μM Compound: Staurosporine	Cytotoxicity against human MCF7 cells after 72 hrs by CellTitre-Glo luminescent cell viability assay Cytotoxicity against human MCF7 cells after 72 hrs by CellTitre-Glo luminescent cell viability assay	[PMID: 24328283]
MCF7	IC₅₀	0.4 μM Compound: STP	Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay	[PMID: 24361521]
MCF7	IC₅₀	1.8 μM Compound: Staurosporine	Antiproliferative activity against human MCF7 cells after 5 days by WST-1 assay Antiproliferative activity against human MCF7 cells after 5 days by WST-1 assay	[PMID: 28956915]
MCF7	EC₅₀	0.1 μM Compound: STS	Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay	[PMID: 29197730]
MCF7	EC₅₀	0.1 μM Compound: STS	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 96 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 96 hrs by SRB assay	[PMID: 30840925]
MCF7	IC₅₀	3.39 μM Compound: Staurosporine	Antiproliferative activity against human MCF7 cells measured after 48 hrs under normoxic condition by MTT assay Antiproliferative activity against human MCF7 cells measured after 48 hrs under normoxic condition by MTT assay	[PMID: 31972394]
MCF7	IC₅₀	9.2 μM Compound: Staurosporine	Antiproliferative activity against human MCF7 cells measured after 48 hrs under CoCl2-induced hypoxic condition by MTT assay Antiproliferative activity against human MCF7 cells measured after 48 hrs under CoCl2-induced hypoxic condition by MTT assay	[PMID: 31972394]
MCF7	IC₅₀	0.33 μM Compound: Staurosporine	Inhibition of VEGFR2 in human MCF7 cells by horseradish peroxidase-coupled TMB substrate based ELISA Inhibition of VEGFR2 in human MCF7 cells by horseradish peroxidase-coupled TMB substrate based ELISA	[PMID: 31992477]
MCF7	IC₅₀	8.81 μM Compound: Staurosporine	Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 3 days by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 3 days by MTT assay	[PMID: 31992477]
MCF7	IC₅₀	0.02 μM Compound: STS	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth	[PMID: 32201021]
MCF7	IC₅₀	0.1 μM Compound: ST	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 32422522]
MCF7	IC₅₀	3.67 μM Compound: Staurosporine	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs under normaxic condition by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs under normaxic condition by MTT assay	[PMID: 32877804]
MCF7	IC₅₀	7.33 μM Compound: Staurosporine	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs under chemically-induced hypoxic condition by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs under chemically-induced hypoxic condition by MTT assay	[PMID: 32877804]
MCF7	EC₅₀	0.1 μM Compound: Staurosporine	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay	[PMID: 33049606]
MCF7	IC₅₀	3.67 μM Compound: Staurosporine	Antiproliferative activity against human MCF7 cells incubated for 2 days by MTT assay Antiproliferative activity against human MCF7 cells incubated for 2 days by MTT assay	[PMID: 33667848]
MCF7	IC₅₀	4.1 μM Compound: Staurosporine	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay	[PMID: 34482273]
MCF7	IC₅₀	6.08 μM Compound: Staurosporine	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 3 days by MTT assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 3 days by MTT assay	[PMID: 34743062]
MCF7	IC₅₀	4.1 μM Compound: Staurosporine	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay	[PMID: 34871842]
MCF7	IC₅₀	6.3 μM Compound: Staurosporine	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by colorimetric based MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by colorimetric based MTT assay	[PMID: 35196017]
MCF7	IC₅₀	7.25 μM Compound: Staurosporine	Anticancer activity against human MCF7 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay Anticancer activity against human MCF7 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay	[PMID: 35694689]
MCF7	IC₅₀	6.76 μM Compound: Staurosporine	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36848846]
MCF7	IC₅₀	3.18 μM Compound: Staurosporine	Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay	[PMID: 37501287]
MCF7	IC₅₀	3.144 μM Compound: Staurosporine	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth by MTT assay	[PMID: 38283222]
MCF7	IC₅₀	16.06 μM Compound: Staurosporine	Antiproliferative activity against Homo sapiens (human) MCF7 cells assessed as growth inhibition after 48 hr by MTT assay Antiproliferative activity against Homo sapiens (human) MCF7 cells assessed as growth inhibition after 48 hr by MTT assay	10.1007/s00044-012-0306-5
MCF7	IC₅₀	0.013 μM Compound: Staurosporine	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay	10.1039/C2MD20098H
MCF7	IC₅₀	0.013 μmol Compound: Staurosporine	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay	10.1039/C2MD20098H
MDA-MB-231	GI₅₀	7.1 nM Compound: staurosporine	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B method Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B method	[PMID: 18484775]
MDA-MB-231	IC₅₀	0.24 μM Compound: Staurosporine	Cytotoxic activity against human MDA-MB-231 cells incubated for 24 hrs by MTT assay Cytotoxic activity against human MDA-MB-231 cells incubated for 24 hrs by MTT assay	[PMID: 28705432]
MDA-MB-231	IC₅₀	4.25 μM Compound: Staurosporine	Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 72 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation measured after 72 hrs by SRB assay	[PMID: 32044580]
MDA-MB-231	IC₅₀	4.31 μM Compound: Staurosporine	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs under normaxic condition by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs under normaxic condition by MTT assay	[PMID: 32877804]
MDA-MB-231	IC₅₀	6.75 μM Compound: Staurosporine	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs under chemically-induced hypoxic condition by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs under chemically-induced hypoxic condition by MTT assay	[PMID: 32877804]
MDA-MB-231	IC₅₀	0.01 μM Compound: Staurosporin	Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 24 hrs Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 24 hrs	[PMID: 33139111]
MDA-MB-231	IC₅₀	2.5 nM Compound: 1	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell metabolic activity after 72 hrs by MTS assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell metabolic activity after 72 hrs by MTS assay	[PMID: 33335665]
MDA-MB-231	IC₅₀	6.75 μM Compound: Staurosporine	Antiproliferative activity against human MDA-MB-231 cells incubated for 2 days by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 2 days by MTT assay	[PMID: 33667848]
MDA-MB-231	IC₅₀	0.00085 μM Compound: Staurosporine	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 34656041]
MDA-MB-231	IC₅₀	0.85 nM Compound: Staurosporine	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 34656041]
MDA-MB-231	IC₅₀	4.385 μM Compound: Staurosporine	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay	[PMID: 38283222]
MDA-MB-453	IC₅₀	0.02351 μM Compound: Staurosporine	Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 34656041]
MDA-MB-468	IC₅₀	0.15 μM Compound: Staurosporine	Cytotoxic activity against human MDA-MB-468 cells incubated for 24 hrs by MTT assay Cytotoxic activity against human MDA-MB-468 cells incubated for 24 hrs by MTT assay	[PMID: 28705432]
MDA-MB-468	IC₅₀	4.37 μM Compound: Staurosporine	Antiproliferative activity against human MDA-MB-468 cells measured after 48 hrs under normoxic condition by MTT assay Antiproliferative activity against human MDA-MB-468 cells measured after 48 hrs under normoxic condition by MTT assay	[PMID: 31972394]
MDA-MB-468	IC₅₀	6.46 μM Compound: Staurosporine	Antiproliferative activity against human MDA-MB-468 cells measured after 48 hrs under CoCl2-induced hypoxic condition by MTT assay Antiproliferative activity against human MDA-MB-468 cells measured after 48 hrs under CoCl2-induced hypoxic condition by MTT assay	[PMID: 31972394]
MDA-MB-468	IC₅₀	0.005 μM Compound: STS	Antiproliferative activity against human MDA-MB-468 cells assessed inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human MDA-MB-468 cells assessed inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37037136]
MDA-MB-468	IC₅₀	6.358 μM Compound: Staurosporine	Cytotoxicity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38107182]
MGC-803	IC₅₀	8.97 μM Compound: Staurosporine	Inhibition of telomerase in human MGC-803 cells after 24 hrs by TRAP-PCR-ELISA assay Inhibition of telomerase in human MGC-803 cells after 24 hrs by TRAP-PCR-ELISA assay	[PMID: 26900656]
MIA PaCa-2	IC₅₀	370 nM Compound: Staurosporine	Antiproliferative activity against MiaPaCa-2 cells by MTT assay Antiproliferative activity against MiaPaCa-2 cells by MTT assay	[PMID: 16403626]
MIA PaCa-2	IC₅₀	370 nM Compound: Staurosporine	Antiproliferative activity against human MiaPaCa-2 cells Antiproliferative activity against human MiaPaCa-2 cells	[PMID: 16413780]
MM1.S	IC₅₀	0.0442 μM Compound: Staurosporine	Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation measured after 72 hrs by by real time imaging analysis Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation measured after 72 hrs by by real time imaging analysis	[PMID: 33248847]
MRC5	GI₅₀	27.27 μM Compound: Staurosporine	Cytotoxicity against human MRC5 cells assessed as cell growth inhibition incubated for 4 days by MTT assay Cytotoxicity against human MRC5 cells assessed as cell growth inhibition incubated for 4 days by MTT assay	[PMID: 37506545]
MV4-11	IC₅₀	0.05 μM Compound: Staurosporine	Cytotoxicity against human MV4-11cells assessed as inhibition of cell viability measured after 72 hrs by real-time IncuCyte proliferation analysis Cytotoxicity against human MV4-11cells assessed as inhibition of cell viability measured after 72 hrs by real-time IncuCyte proliferation analysis	[PMID: 34352711]
N2a	IC₅₀	0.0113 μM Compound: Staurosporine	Cytotoxicity against mouse Neuro2a cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against mouse Neuro2a cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 28152427]
NALM-6	EC₅₀	1.4 μM Compound: STS	Antiproliferative activity against human NALM6 cells after 72 hrs by CellTiter-Glo luminescent cell viability assay Antiproliferative activity against human NALM6 cells after 72 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 30840453]
NCI-H1975	IC₅₀	0.005 μM Compound: Staurosporine	Anticancer activity against TKI resistant human NCI-H1975 cells harboring EGFR L858R/T790M mutant assessed as inhibition of cell growth Anticancer activity against TKI resistant human NCI-H1975 cells harboring EGFR L858R/T790M mutant assessed as inhibition of cell growth	[PMID: 38199330]
NCI-H460	GI₅₀	3.6 μM Compound: Staurosporine	Cytotoxicity against human H460 cells after 48 hrs by SRB assay Cytotoxicity against human H460 cells after 48 hrs by SRB assay	[PMID: 21513294]
NCI-H460	IC₅₀	11.5 μM Compound: Staurosporine	Cytostatic activity against human NCI-H460 cells Cytostatic activity against human NCI-H460 cells	[PMID: 30738653]
NCI-H460	IC₅₀	0.024 μM Compound: Staurosporine	Antiproliferative activity against human NCI-H460 cells Antiproliferative activity against human NCI-H460 cells	[PMID: 31005446]
NCI-H460	IC₅₀	0.06 μM Compound: STS	Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging assay Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging assay	[PMID: 32832030]
NCI-H460	IC₅₀	0.0597 μM Compound: Staurosporine	Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell proliferation measured after 72 hrs by by real time imaging analysis Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell proliferation measured after 72 hrs by by real time imaging analysis	[PMID: 33248847]
NCI-H460	IC₅₀	>0.1 μM Compound: Staurosporine	Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell viability measured after 72 hrs by colorimetric MTS viability assay Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell viability measured after 72 hrs by colorimetric MTS viability assay	[PMID: 34352711]
NIH3T3	IC₅₀	140.12 μM Compound: Staurosporine	Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay	[PMID: 24286761]
NIH3T3	IC₅₀	0.2 μM Compound: STP	Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay	[PMID: 24361521]
NIH3T3	EC₅₀	0.008 μM Compound: STS	Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay	[PMID: 29197730]
NIH3T3	EC₅₀	0.008 μM Compound: STS	Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 96 hrs by SRB assay Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 96 hrs by SRB assay	[PMID: 30840925]
NIH3T3	IC₅₀	0.008 μM Compound: ST	Cytotoxicity against mouse NIH3T3 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Cytotoxicity against mouse NIH3T3 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 32422522]
NIH3T3	EC₅₀	0.008 μM Compound: Staurosporine	Cytotoxicity against mouse NIH3T3 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay Cytotoxicity against mouse NIH3T3 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay	[PMID: 33049606]
P19	IC₅₀	>10 μM Compound: Staurosporine	Inhibition of Casein kinase 2 of P19 cells Inhibition of Casein kinase 2 of P19 cells	[PMID: 15771419]
P19	IC₅₀	>10 μM Compound: Staurosporine	Inhibition of Epidermal growth factor receptor in P19 cells Inhibition of Epidermal growth factor receptor in P19 cells	[PMID: 15771419]
P19	IC₅₀	>10 μM Compound: Staurosporine	Inhibition of Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 in P19 cells Inhibition of Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 in P19 cells	[PMID: 15771419]
P19	IC₅₀	0.002 μM Compound: Staurosporine	Inhibition of Platelet-derived growth factor receptor in P19 cells Inhibition of Platelet-derived growth factor receptor in P19 cells	[PMID: 15771419]
P19	IC₅₀	0.004 μM Compound: Staurosporine	Inhibition of Protein Kinase A in P19 cells Inhibition of Protein Kinase A in P19 cells	[PMID: 15771419]
P19	IC₅₀	0.006 μM Compound: Staurosporine	Inhibition of Calcium/calmodulin-dependent protein kinase type II in P19 cells Inhibition of Calcium/calmodulin-dependent protein kinase type II in P19 cells	[PMID: 15771419]
P19	IC₅₀	0.008 μM Compound: Staurosporine	Inhibition of Cyclin-dependent kinase 1 in P19 cells Inhibition of Cyclin-dependent kinase 1 in P19 cells	[PMID: 15771419]
P19	IC₅₀	0.014 μM Compound: Staurosporine	Inhibition of Vascular endothelial growth factor receptor in P19 cells Inhibition of Vascular endothelial growth factor receptor in P19 cells	[PMID: 15771419]
P19	IC₅₀	0.2 μM Compound: Staurosporine	Inhibition of Insulin receptor kinase in P19 cells Inhibition of Insulin receptor kinase in P19 cells	[PMID: 15771419]
P19	IC₅₀	1.4 μM Compound: Staurosporine	Inhibition of Casein kinase 1 in P19 cells Inhibition of Casein kinase 1 in P19 cells	[PMID: 15771419]
P388	ED₅₀	<0.08 μg/mL Compound: 1	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 3204380]
PANC-1	IC₅₀	0.02 μM Compound: STS	Antiproliferative activity against human PANC1 cells assessed as inhibition of cell growth Antiproliferative activity against human PANC1 cells assessed as inhibition of cell growth	[PMID: 32201021]
PBMC	IC₅₀	0.016 μM Compound: 1	Suppression of IL2 production in human PBMC after 24 hrs by ELISA Suppression of IL2 production in human PBMC after 24 hrs by ELISA	[PMID: 18585046]
PBMC	IC₅₀	0.016 μM Compound: staurosporine	Inhibition of IL2 production in PHA-stimulated human PBMC after 24 hrs by ELISA Inhibition of IL2 production in PHA-stimulated human PBMC after 24 hrs by ELISA	[PMID: 18823784]
PBMC	IC₅₀	0.0002 μM Compound: Staurosporine	Cytotoxicity against human PBMC cells assessed as inhibition of cell proliferation measured after 72 hrs by radioactive cell proliferation assay Cytotoxicity against human PBMC cells assessed as inhibition of cell proliferation measured after 72 hrs by radioactive cell proliferation assay	[PMID: 33248847]
PBMC	IC₅₀	0.2 nM Compound: Staurosporine	Cytotoxicity against human PBMC cells assessed as inhibition of cell proliferation measured after 72 hrs by radioactive cell proliferation assay Cytotoxicity against human PBMC cells assessed as inhibition of cell proliferation measured after 72 hrs by radioactive cell proliferation assay	[PMID: 33248847]
PC-3	IC₅₀	0.031 μM Compound: staurosporine	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay Cytotoxicity against human PC3 cells after 48 hrs by MTT assay	[PMID: 25825934]
PC-3	IC₅₀	0.017 μM Compound: Staurosporine	Cytotoxicity against human PC3 cells by sulforhodamine B assay Cytotoxicity against human PC3 cells by sulforhodamine B assay	[PMID: 29389122]
PC-3	IC₅₀	0.039 μM Compound: STU	Cytotoxicity against human PC3 cells after 72 hrs by SRB assay Cytotoxicity against human PC3 cells after 72 hrs by SRB assay	[PMID: 29558119]
PC-3	IC₅₀	4.91 μM Compound: Staurosporine	Antiproliferative activity against human PC3 cells measured after 72 hrs under normoxic condition by MTT assay Antiproliferative activity against human PC3 cells measured after 72 hrs under normoxic condition by MTT assay	[PMID: 31794211]
PC-3	IC₅₀	5.92 μM Compound: Staurosporine	Antiproliferative activity against human PC3 cells measured after 72 hrs under CoCl2-induced hypoxic condition by MTT assay Antiproliferative activity against human PC3 cells measured after 72 hrs under CoCl2-induced hypoxic condition by MTT assay	[PMID: 31794211]
PC-3	IC₅₀	0.36 μM Compound: Staurosporine	Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36848846]
Platelet	IC₅₀	48 nM Compound: Staurosporine	Inhibition of alpha-thrombin induced human Platelet aggregation pre-incubated for 1 min followed by alpha-thrombin stimulation and measured after 30 sec by aggregometer assay Inhibition of alpha-thrombin induced human Platelet aggregation pre-incubated for 1 min followed by alpha-thrombin stimulation and measured after 30 sec by aggregometer assay	[PMID: 1874734]
Platelet	IC₅₀	76 nM Compound: Staurosporine	Inhibition of collagen induced human Platelet aggregation pre-incubated for 1 min followed by collagen stimulation and measured after 30 sec by aggregometer assay Inhibition of collagen induced human Platelet aggregation pre-incubated for 1 min followed by collagen stimulation and measured after 30 sec by aggregometer assay	[PMID: 1874734]
Raji	EC₅₀	<2 μM Compound: Staurosporine	Cytotoxicity against human Raji cells Cytotoxicity against human Raji cells	[PMID: 25316317]
RBL-2H3	IC₅₀	0.2 μM Compound: Staurosporine	Anti-allergic activity in rat RBL2H3 cells assessed as reduction in mouse anti-DNP IgE-induced IL-4 level preincubated for 15 mins followed by mouse anti-DNP IgE-stimulation and measured after 3 hrs by ELISA Anti-allergic activity in rat RBL2H3 cells assessed as reduction in mouse anti-DNP IgE-induced IL-4 level preincubated for 15 mins followed by mouse anti-DNP IgE-stimulation and measured after 3 hrs by ELISA	[PMID: 30711393]
RBL-2H3	IC₅₀	0.3 μM Compound: Staurosporine	Anti-allergic activity in rat RBL2H3 cells assessed as reduction in mouse anti-DNP IgE-induced beta-hexosaminidase release preincubated for 15 mins followed by mouse anti-DNP IgE-stimulation and measured after 3 hrs by p-nitrophenyl-2-acetamide-2-deoxy-be Anti-allergic activity in rat RBL2H3 cells assessed as reduction in mouse anti-DNP IgE-induced beta-hexosaminidase release preincubated for 15 mins followed by mouse anti-DNP IgE-stimulation and measured after 3 hrs by p-nitrophenyl-2-acetamide-2-deoxy-be	[PMID: 30711393]
RBL-2H3	IC₅₀	0.3 μM Compound: Staurosporine	Anti-allergic activity in rat RBL2H3 cells assessed as reduction in mouse anti-DNP IgE-induced TNF-alpha level preincubated for 15 mins followed by mouse anti-DNP IgE-stimulation and measured after 3 hrs by ELISA Anti-allergic activity in rat RBL2H3 cells assessed as reduction in mouse anti-DNP IgE-induced TNF-alpha level preincubated for 15 mins followed by mouse anti-DNP IgE-stimulation and measured after 3 hrs by ELISA	[PMID: 30711393]
RBL-2H3	IC₅₀	0.7 μM Compound: Staurosporine	Anti-allergic activity in rat RBL2H3 cells assessed as reduction in calcium ionophore-induced IL-4 level preincubated for 15 mins followed by calcium ionophore stimulation and measured after 3 hrs by ELISA Anti-allergic activity in rat RBL2H3 cells assessed as reduction in calcium ionophore-induced IL-4 level preincubated for 15 mins followed by calcium ionophore stimulation and measured after 3 hrs by ELISA	[PMID: 30711393]
RBL-2H3	IC₅₀	1 μM Compound: Staurosporine	Anti-allergic activity in rat RBL2H3 cells assessed as reduction in calcium ionophore-induced beta-hexosaminidase release preincubated for 15 mins followed by calcium ionophore-stimulation and measured after 3 hrs by p-nitrophenyl-2-acetamide-2-deoxy-beta Anti-allergic activity in rat RBL2H3 cells assessed as reduction in calcium ionophore-induced beta-hexosaminidase release preincubated for 15 mins followed by calcium ionophore-stimulation and measured after 3 hrs by p-nitrophenyl-2-acetamide-2-deoxy-beta	[PMID: 30711393]
RBL-2H3	IC₅₀	1 μM Compound: Staurosporine	Anti-allergic activity in rat RBL2H3 cells assessed as reduction in calcium ionophore-induced TNF-alpha level preincubated for 15 mins followed by calcium ionophore stimulation and measured after 3 hrs by ELISA Anti-allergic activity in rat RBL2H3 cells assessed as reduction in calcium ionophore-induced TNF-alpha level preincubated for 15 mins followed by calcium ionophore stimulation and measured after 3 hrs by ELISA	[PMID: 30711393]
RBL-2H3	IC₅₀	0.3 μM Compound: Staurosporine	Inhibition of PKC in rat RBL2H3 cells assessed as inhibition of mouse anti-DNP IgE-stimulated beta-hexosaminidase release preincubated for 15 mins followed by mouse anti-DNP IgE stimulation and measured after 3 hrs by 4-nitropheny1-2-acetamide-2-deoxy-bet Inhibition of PKC in rat RBL2H3 cells assessed as inhibition of mouse anti-DNP IgE-stimulated beta-hexosaminidase release preincubated for 15 mins followed by mouse anti-DNP IgE stimulation and measured after 3 hrs by 4-nitropheny1-2-acetamide-2-deoxy-bet	[PMID: 31879206]
RBL-2H3	IC₅₀	0.5 μM Compound: Staurosporine	Inhibition of PKC in rat RBL2H3 cells assessed as inhibition of anti-DNP IgE-stimulated TNFalpha release preincubated for 15 mins followed by mouse anti-DNP IgE stimulation and measured after 3 hrs by ELISA Inhibition of PKC in rat RBL2H3 cells assessed as inhibition of anti-DNP IgE-stimulated TNFalpha release preincubated for 15 mins followed by mouse anti-DNP IgE stimulation and measured after 3 hrs by ELISA	[PMID: 31879206]
RBL-2H3	IC₅₀	0.8 μM Compound: Staurosporine	Inhibition of PKC in rat RBL2H3 cells assessed as inhibition of ionomycin-stimulated beta-hexosaminidase release preincubated for 15 mins followed by ionomycin stimulation and measured after 3 hrs by 4-nitropheny1-2-acetamide-2-deoxy-beta-glucopyranoside Inhibition of PKC in rat RBL2H3 cells assessed as inhibition of ionomycin-stimulated beta-hexosaminidase release preincubated for 15 mins followed by ionomycin stimulation and measured after 3 hrs by 4-nitropheny1-2-acetamide-2-deoxy-beta-glucopyranoside	[PMID: 31879206]
RBL-2H3	IC₅₀	1 μM Compound: Staurosporine	Inhibition of PKC in rat RBL2H3 cells assessed as inhibition of ionomycin-stimulated TNFalpha release preincubated for 15 mins followed by ionomycin stimulation and measured after 3 hrs by ELISA Inhibition of PKC in rat RBL2H3 cells assessed as inhibition of ionomycin-stimulated TNFalpha release preincubated for 15 mins followed by ionomycin stimulation and measured after 3 hrs by ELISA	[PMID: 31879206]
Rec1	IC₅₀	0.0255 μM Compound: Staurosporine	Cytotoxicity against human REC1 cells assessed as inhibition of cell viability measured after 72 hrs by real-time IncuCyte proliferation analysis Cytotoxicity against human REC1 cells assessed as inhibition of cell viability measured after 72 hrs by real-time IncuCyte proliferation analysis	[PMID: 34352711]
RXF 393	GI₅₀	0.95 μM Compound: Staurosporine	Cytotoxicity against human RXF 393 cells assessed as cell growth inhibition incubated for 4 days by MTT assay Cytotoxicity against human RXF 393 cells assessed as cell growth inhibition incubated for 4 days by MTT assay	[PMID: 37506545]
Sf21	IC₅₀	6 nM Compound: 2	Inhibition of JAK3 expressed in Sf21 cells Inhibition of JAK3 expressed in Sf21 cells	[PMID: 17088059]
Sf21	IC₅₀	6 nM Compound: staurosporine	Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylation Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylation	[PMID: 19427203]
Sf21	IC₅₀	0.027 μM Compound: staurosporine	Inhibition of human CHK2 kinase expressed in insect Sf21 cells using phospho-CREBtide as substrate at 30 uM Inhibition of human CHK2 kinase expressed in insect Sf21 cells using phospho-CREBtide as substrate at 30 uM	[PMID: 21334796]
Sf21	IC₅₀	0.039 μM Compound: staurosporine	Inhibition of human recombinant IKK-alpha expressed in insect Sf21 cells using phospho-Ulight-IkappaB-alpha as substrate at 30 uM Inhibition of human recombinant IKK-alpha expressed in insect Sf21 cells using phospho-Ulight-IkappaB-alpha as substrate at 30 uM	[PMID: 21334796]
Sf21	IC₅₀	0.49 μM Compound: staurosporine	Inhibition of human recombinant IKK-beta expressed in insect Sf21 cells using phospho-Ulight-IkappaB-alpha as substrate at 30 uM Inhibition of human recombinant IKK-beta expressed in insect Sf21 cells using phospho-Ulight-IkappaB-alpha as substrate at 30 uM	[PMID: 21334796]
Sf21	IC₅₀	1325 nM Compound: Staurosporine	Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 5 mins by time resolved-fluorescent assay Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 5 mins by time resolved-fluorescent assay	[PMID: 21441024]
Sf21	IC₅₀	1533 nM Compound: Staurosporine	Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 30 mins by time resolved-fluorescent assay Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 30 mins by time resolved-fluorescent assay	[PMID: 21441024]
Sf21	IC₅₀	1646 nM Compound: Staurosporine	Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 60 mins by time resolved-fluorescent assay Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 60 mins by time resolved-fluorescent assay	[PMID: 21441024]
Sf21	IC₅₀	1701 nM Compound: Staurosporine	Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 10 mins by time resolved-fluorescent assay Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 10 mins by time resolved-fluorescent assay	[PMID: 21441024]
Sf21	IC₅₀	0.002 μM Compound: Staurosporine	Inhibition of human recombinant JAK2 expressed in Sf21 cells assessed as reduction in Ulight-CAGAGAIETDKEYYTVKD phosphorylation pre-incubated before substrate addition and measured after 60 mins by LANCE detection method Inhibition of human recombinant JAK2 expressed in Sf21 cells assessed as reduction in Ulight-CAGAGAIETDKEYYTVKD phosphorylation pre-incubated before substrate addition and measured after 60 mins by LANCE detection method	[PMID: 27137359]
SF-268	GI₅₀	0.044 μM Compound: Staurosporine	Cytotoxicity against human SF268 cells after 48 hrs by SRB assay Cytotoxicity against human SF268 cells after 48 hrs by SRB assay	[PMID: 21513294]
Sf9	IC₅₀	0.005 μM Compound: Staurosporine	Inhibition of human Fyn expressed in Sf9 cells after 1 min by ELISA in presence of 1 umol/L ATP Inhibition of human Fyn expressed in Sf9 cells after 1 min by ELISA in presence of 1 umol/L ATP	[PMID: 17315853]
Sf9	IC₅₀	0.015 μM Compound: Staurosporine	Inhibition of human Fyn expressed in Sf9 cells after 20 mins by ELISA in presence of 1 umol/L ATP Inhibition of human Fyn expressed in Sf9 cells after 20 mins by ELISA in presence of 1 umol/L ATP	[PMID: 17315853]
Sf9	IC₅₀	0.036 μM Compound: Staurosporine	Inhibition of human Fyn expressed in Sf9 cells after 1 min by ELISA in presence of 10 umol/L ATP Inhibition of human Fyn expressed in Sf9 cells after 1 min by ELISA in presence of 10 umol/L ATP	[PMID: 17315853]
Sf9	IC₅₀	0.083 μM Compound: Staurosporine	Inhibition of human Fyn expressed in Sf9 cells after 20 mins by ELISA in presence of 10 umol/L ATP Inhibition of human Fyn expressed in Sf9 cells after 20 mins by ELISA in presence of 10 umol/L ATP	[PMID: 17315853]
Sf9	IC₅₀	0.27 μM Compound: Staurosporine	Inhibition of human Fyn expressed in Sf9 cells after 1 min by ELISA in presence of 100 umol/L ATP Inhibition of human Fyn expressed in Sf9 cells after 1 min by ELISA in presence of 100 umol/L ATP	[PMID: 17315853]
Sf9	IC₅₀	0.51 μM Compound: Staurosporine	Inhibition of human Fyn expressed in Sf9 cells after 20 mins by ELISA in presence of 100 umol/L ATP Inhibition of human Fyn expressed in Sf9 cells after 20 mins by ELISA in presence of 100 umol/L ATP	[PMID: 17315853]
Sf9	IC₅₀	0.003 μM Compound: staurosporine	Inhibition of human Syk expressed in Sf9 cells Inhibition of human Syk expressed in Sf9 cells	[PMID: 18823784]
Sf9	IC₅₀	0.053 μM Compound: staurosporine	Inhibition of human ZAP70 expressed in Sf9 cells Inhibition of human ZAP70 expressed in Sf9 cells	[PMID: 18823784]
Sf9	IC₅₀	2.3 μM Compound: staurosporine	Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assay	[PMID: 20580552]
Sf9	IC₅₀	>18.5 μM Compound: Staurosporine	Inhibition of human recombinant ALK5 expressed in insect Sf9 cells using casein as substrate by radioisotopic assay Inhibition of human recombinant ALK5 expressed in insect Sf9 cells using casein as substrate by radioisotopic assay	[PMID: 24786585]
Sf9	IC₅₀	1.2 nM Compound: Staurosporine	Inhibition of N-terminal GST tagged recombinant full-length human CHK1 expressed in baculovirus Sf9 insect cells after 10 mins by luminescent ADP-Glo assay Inhibition of N-terminal GST tagged recombinant full-length human CHK1 expressed in baculovirus Sf9 insect cells after 10 mins by luminescent ADP-Glo assay	[PMID: 27089211]
Sf9	IC₅₀	0.0039 μM Compound: Staurosporine	Inhibition of N-terminal His-tagged recombinant human AXL (473 to end amino acids) expressed by baculovirus in Sf9 cells using axltide substrate and ATP by ADP-Glo luminescence assay Inhibition of N-terminal His-tagged recombinant human AXL (473 to end amino acids) expressed by baculovirus in Sf9 cells using axltide substrate and ATP by ADP-Glo luminescence assay	[PMID: 30340900]
Sf9	IC₅₀	2.0 x 10^-8 M Compound: staurosporine	Inhibition of protein kinase C(1:1mixture of PKC alpha & beta) expressed in Sf9 insect cells Inhibition of protein kinase C(1:1mixture of PKC alpha & beta) expressed in Sf9 insect cells	[PMID: 9873605]
Splenocyte	IC₅₀	0.4 μM Compound: 1 (Staurosporine)	In vitro for inhibitory activity against tyrosine specific protein kinase from murine spleen cells (T-kinase) In vitro for inhibitory activity against tyrosine specific protein kinase from murine spleen cells (T-kinase)	10.1016/S0960-894X(01)80995-1
SR	GI₅₀	6.29 μM Compound: Staurosporine	Cytotoxicity against human SR cells assessed as cell growth inhibition incubated for 4 days by MTT assay Cytotoxicity against human SR cells assessed as cell growth inhibition incubated for 4 days by MTT assay	[PMID: 37506545]
SR	IC₅₀	2.62 μM Compound: Staurosporine	Antiproliferative activity against human SR cells assessed as inhibition of cell growth incubated for 2 to 4 hrs by MTT assay Antiproliferative activity against human SR cells assessed as inhibition of cell growth incubated for 2 to 4 hrs by MTT assay	[PMID: 38389871]
ST486	IC₅₀	0.007 μM Compound: Staurosporine	Antiproliferative activity against human ST486 cells after 48 to 72 hrs by MTT assay Antiproliferative activity against human ST486 cells after 48 to 72 hrs by MTT assay	[PMID: 22182929]
SUP-B15	EC₅₀	0.55 μM Compound: STS	Antiproliferative activity against human SUP-B15 cells after 72 hrs by CellTiter-Glo luminescent cell viability assay Antiproliferative activity against human SUP-B15 cells after 72 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 30840453]
SW 1116	EC₅₀	24.92 μg/mL Compound: Staurosporine	Antiproliferative activity against human SW1116 cells after 48 hrs by MTT assay Antiproliferative activity against human SW1116 cells after 48 hrs by MTT assay	[PMID: 21889345]
SW 1116	IC₅₀	8.32 μM Compound: Staurosporine	Inhibition of telomerase in human SW1116 cells after 24 hrs by TRAP-PCR-ELISA assay Inhibition of telomerase in human SW1116 cells after 24 hrs by TRAP-PCR-ELISA assay	[PMID: 21962523]
SW 1116	IC₅₀	4.95 μM Compound: Staurosporine	Antiproliferative activity against human SW1116 cells after 48 hrs by MTT method Antiproliferative activity against human SW1116 cells after 48 hrs by MTT method	[PMID: 23018096]
SW 1116	IC₅₀	4.18 μM Compound: Staurosporine	Inhibition of telomerase in human SW1116 cells after 24 hrs by TRAP-PCR-ELISA assay Inhibition of telomerase in human SW1116 cells after 24 hrs by TRAP-PCR-ELISA assay	[PMID: 24286761]
SW-1736	EC₅₀	0.2 μM Compound: STS	Cytotoxicity against human SW1736 cells assessed as reduction in cell viability after 96 hrs by SRB assay Cytotoxicity against human SW1736 cells assessed as reduction in cell viability after 96 hrs by SRB assay	[PMID: 30840925]
SW480	IC₅₀	<0.1 μM Compound: Staurosporine	Antiproliferative activity against human SW480 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human SW480 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 31740249]
T47D	IC₅₀	4.52 μM Compound: Staurosporine	Cytotoxicity against human T47D cells assessed as inhibition of cell proliferation measured after 72 hrs by SRB assay Cytotoxicity against human T47D cells assessed as inhibition of cell proliferation measured after 72 hrs by SRB assay	[PMID: 32044580]
T47D	IC₅₀	11.7 μM Compound: Staurosporine	Cytotoxicity against human T47D cells assessed as reduction in cell viability after 3 hrs by MTT assay Cytotoxicity against human T47D cells assessed as reduction in cell viability after 3 hrs by MTT assay	[PMID: 33962153]
T47D	IC₅₀	7.12 μM Compound: Staurosporine	Antiproliferative activity against human T47D cells incubated for 48 hrs by MTT assay Antiproliferative activity against human T47D cells incubated for 48 hrs by MTT assay	[PMID: 37501287]
T47D	IC₅₀	4.849 μM Compound: Staurosporine	Cytotoxicity against human T47D cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against human T47D cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38107182]
TERT-RPE1	IC₅₀	0.25 μM Compound: Staurosporine	Cytostatic activity against human hTERT-RPE1 cells Cytostatic activity against human hTERT-RPE1 cells	[PMID: 30738653]
TERT-RPE1	IC₅₀	0.0055 μM Compound: Staurosporine	Cytotoxicity against human TERT-RPE1 cells assessed as inhibition of cell proliferation measured after 72 hrs by real time imaging analysis Cytotoxicity against human TERT-RPE1 cells assessed as inhibition of cell proliferation measured after 72 hrs by real time imaging analysis	[PMID: 33248847]
U-87MG ATCC	IC₅₀	0.02 μM Compound: STS	Antiproliferative activity against human U87MG cells assessed as inhibition of cell growth Antiproliferative activity against human U87MG cells assessed as inhibition of cell growth	[PMID: 32201021]
U-937	IC₅₀	2 μM Compound: staurosporine	Cytotoxicity against human U937 cells Cytotoxicity against human U937 cells	[PMID: 17088067]
UoC-B1	EC₅₀	2 μM Compound: STS	Antiproliferative activity against human UOCB1 cells after 72 hrs by CellTiter-Glo luminescent cell viability assay Antiproliferative activity against human UOCB1 cells after 72 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 30840453]
Vero	IC₅₀	0.0024 μM Compound: Staurosporine	Cytotoxicity against African green monkey Vero cells after 2 days by CellTiter-Glo luminescent cell viability assay Cytotoxicity against African green monkey Vero cells after 2 days by CellTiter-Glo luminescent cell viability assay	[PMID: 28993106]
Vero	IC₅₀	0.028 μM Compound: Staurosporine	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 30743094]
WI-38	IC₅₀	24.41 μM Compound: Staurosporine	Cytotoxicity against human WI-38 cells assessed as cell viability measured by MTT assay Cytotoxicity against human WI-38 cells assessed as cell viability measured by MTT assay	[PMID: 34246754]
Z-138	IC₅₀	21.5 μM Compound: Staurosporine	Cytostatic activity against human Z138 cells Cytostatic activity against human Z138 cells	[PMID: 30738653]
Z-138	IC₅₀	0.018 μM Compound: Staurosporine	Antiproliferative activity against human Z138 cells Antiproliferative activity against human Z138 cells	[PMID: 31005446]
Z-138	IC₅₀	0.02 μM Compound: STS	Antiproliferative activity against human Z138 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging assay Antiproliferative activity against human Z138 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging assay	[PMID: 32832030]
Z-138	IC₅₀	0.0067 μM Compound: Staurosporine	Antiproliferative activity against human Z138 cells assessed as inhibition of cell proliferation measured after 72 hrs by by real time imaging analysis Antiproliferative activity against human Z138 cells assessed as inhibition of cell proliferation measured after 72 hrs by by real time imaging analysis	[PMID: 33248847]
Z-138	IC₅₀	0.0418 μM Compound: Staurosporine	Antiproliferative activity against human Z138 cells assessed as inhibition of cell viability measured after 72 hrs by real-time IncuCyte proliferation analysis Antiproliferative activity against human Z138 cells assessed as inhibition of cell viability measured after 72 hrs by real-time IncuCyte proliferation analysis	[PMID: 34352711]

In Vitro

Staurosporine (GMP) (316 nM; 24 h) induces the production of robust neurite in RGC-5 cells^[1].
Staurosporine (GMP) (25 and 100 nM; 12 h) induces differentiation of SH-SY5Y cells with the increasing of neurite processes combined with a prominent branching and the subsequent reduction in cell body size^[2].
Staurosporine (GMP) (20 nM) induces cell differentiation of human neuroblastoma cell line^[3].
Staurosporine (GMP) (5 nM) enhances HL-60-cell differentiation induced by 1 alpha,25 dihydroxyvitamin D3, dbc AMP, all-trans-beta-retinoic acid (RA), actinomycin D (Act D) and other compounds^[4].
Staurosporine (GMP) (1 μM; 15 d) induces differentiation of human neuroblastoma cells^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 62996-74-1
Appearance Solid
Molecular Weight 466.53
Formula C₂₈H₂₆N₄O₃
Color Off-white to light yellow
SMILES

O=C(NC1)C2=C1C3=C(C4=C2C5=C(C=CC=C5)N4[C@H]6C[C@@H](NC)[C@@H](OC)[C@]7(C)O6)N7C8=CC=CC=C83
Synonyms

Antibiotic AM-2282 (GMP); STS (GMP); AM-2282 (GMP)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (418 KB)
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- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ganapathy PS, et al. Sensitivity of staurosporine-induced differentiated RGC-5 cells to homocysteine. Curr Eye Res. 2010 Jan;35(1):80-90. [Content Brief]

[2]. Pregi N, et al. Effect of erythropoietin on staurosporine-induced apoptosis and differentiation of SH-SY5Y neuroblastoma cells. Biochim Biophys Acta. 2006 Feb;1763(2):238-46. [Content Brief]

[3]. Hajimu MORIOKA, et al. Staurosporine-induced Differentiation in a Human Neuroblastoma Cell Line, NB-1. Agricultural and Biological Chemistry. 1985; 1959-1963.

[4]. Okazaki T, et al. Staurosporine, a novel protein kinase inhibitor, enhances HL-60-cell differentiation induced by various compounds. Exp Hematol. 1988 Jan;16(1):42-8. [Content Brief]

[5]. Yuste VJ, et al. The prevention of the staurosporine-induced apoptosis by Bcl-X(L), but not by Bcl-2 or caspase inhibitors, allows the extensive differentiation of human neuroblastoma cells. J Neurochem. 2002 Jan;80(1):126-39. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

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Product Name:
CAS No.:
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Staurosporine (GMP)

RepSox (GMP)

Staurosporine

Retinoic acid (GMP)

Staurosporine (Standard)

LDN193189 (GMP)

K-252a

Verbascoside

Sotrastaurin

SB 525334

Rottlerin

D-erythro-Sphingosine

Go 6983

All PKC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

Staurosporine (GMP)

RepSox (GMP)

Staurosporine

Retinoic acid (GMP)

Staurosporine (Standard)

LDN193189 (GMP)

K-252a

Verbascoside

Sotrastaurin

SB 525334

Rottlerin

D-erythro-Sphingosine

Go 6983

All PKC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Staurosporine (GMP) Related Classifications

HY-15141G Related Classifications

Bioz