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  3. Antibiotic Bacterial
  4. Sulfamethoxazole sodium

Sulfamethoxazole sodium  (Synonyms: Ro 4-2130 sodium)

製品番号: HY-B0322A 純度: 99.45%
COA 取扱説明書 Technical Support

Sulfamethoxazole (Ro 4-2130) sodium is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole sodium inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole sodium can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis.

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CAS 番号 : 4563-84-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 86 在庫あり
Solution
10 mM * 1 mL in DMSO USD 86 在庫あり
Solid
100 mg $79 在庫あり
500 mg $119 在庫あり
1 g $143 在庫あり
5 g $215 在庫あり
10 g $258 在庫あり
25 g $325 在庫あり
50 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 24 publication(s) in Google Scholar

Other Forms of Sulfamethoxazole sodium:

Sulfamethoxazole sodium 関連抗体

Top Publications Citing Use of Products

    Sulfamethoxazole sodium purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2023 Mar 15:253:114711.  [Abstract]

    Heat map of several key genes involved in immunity, metabolism, and circadian rhythm within the gut of juvenile and adult seahorses treated with Sulfamethoxazole (SMX) (1 μg/L; 4 weeks) was constructed using Tbtools software.

    Sulfamethoxazole sodium purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2023 Mar 15:253:114711.  [Abstract]

    Sulfamethoxazole (SMX) (1 μg/L; 4 weeks) increased the relative abundance of Proteobacteria, whereas decreased the relative abundance of Actinobacteria and Acidobacteria.

    Sulfamethoxazole sodium purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2023 Mar 15:253:114711.  [Abstract]

    Sulfamethoxazole (SMX) (1 μg/L; 4 weeks) significantly increased the ACE index, but significantly reduced the Simpson's index.

    Sulfamethoxazole sodium purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2023 Mar 15:253:114711.  [Abstract]

    Sulfamethoxazole (SMX) (1 μg/L; 4 weeks) considerably increased the relative abundances of potential pathogens.

    Sulfamethoxazole sodium purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2023 Mar 15:253:114711.  [Abstract]

    Sulfamethoxazole (SMX) (1 μg/L; 4 weeks). Heat map of some of representative genes related to immunity and drug metabolism in seahorse brood pouches.

    Antibiotic アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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    • 純度とドキュメンテーション

    • 参考文献

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    製品説明

    Sulfamethoxazole (Ro 4-2130) sodium is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole sodium inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole sodium can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis[1][2][3].

    体外実験

    Sulfamethoxazole (0.01-1.28 mg/mL; 120 h) sodium inhibits P. lutzii mitochondrial activity[1].
    Sulfamethoxazole (0.01 mg/mL; 1-2 h) sodium acts in P. lutzii as a competitor for amino acid, nucleic acids and folate cofactor biosynthesis, disrupting mitochondrial functions[1].
    Sulfamethoxazole sodium at different concentrations, by using the whole-cell patch clamp recording method, inhibits the KATP channel currents in mouse pancreatic β cells in a dose-dependent manner, and the IC50 is 0.46 mM[3].
    Sulfamethoxazole sodium at different concentrations, through the static incubation assay of islets, stimulates insulin secretion in mouse islets. It can stimulate insulin secretion at a low concentration (0.1 mM) under high-glucose (10 mM) conditions and only at a high concentration (10 mM) under low-glucose (2 mM) conditions[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Sulfamethoxazole sodium 関連抗体

    Cell Viability Assay[1]

    Cell Line: P. lutzii yeast cells
    Concentration: 1.28 mg/mL, 0.64 mg/mL, 0.32 mg/mL, 0.16 mg/mL, 0.08 mg/mL, 0.04 mg/mL, 0.02 mg/mL, and 0.01 mg/mL
    Incubation Time: 120 h
    Result: Produced a marked dose-dependent adverse effect on P. lutzii.

    RT-PCR[1]

    Cell Line: P. lutzii yeast cells
    Concentration: 0.01 mg/mL
    Incubation Time: 1 or 2 h
    Result: The up-regulated genes included those for HSP70, HSP60, and HSP30.
    The down-regulated genes included betaine aldehyde dehydrogenase (BADH), carnitine/acyl carnitine carrier (ACUH), guanine nucleotide binding protein α-1 subunit (GPA2), C6 transcription factor (CTF1B) and pleckstrin homology domain (PH).
    分子量

    275.26

    分子式

    C10H10N3NaO3S
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=S(C1=CC=C(N)C=C1)([N-]C2=NOC(C)=C2)=O.[Na+]
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
    溶剤 & 溶解度
    体外: 

    H2O : ≥ 100 mg/mL (363.29 mM)

    DMSO : 50 mg/mL (181.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.6329 mL 18.1646 mL 36.3293 mL
    5 mM 0.7266 mL 3.6329 mL 7.2659 mL
    10 mM 0.3633 mL 1.8165 mL 3.6329 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    一般には略語で表示されます：C1V1 = C2V2

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    In Vivo Dissolution Calculator
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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.45%

    COA (249 KB) HNMR (255 KB) LCMS (94 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 3.6329 mL 18.1646 mL 36.3293 mL 90.8232 mL
    5 mM 0.7266 mL 3.6329 mL 7.2659 mL 18.1646 mL
    10 mM 0.3633 mL 1.8165 mL 3.6329 mL 9.0823 mL
    15 mM 0.2422 mL 1.2110 mL 2.4220 mL 6.0549 mL
    20 mM 0.1816 mL 0.9082 mL 1.8165 mL 4.5412 mL
    25 mM 0.1453 mL 0.7266 mL 1.4532 mL 3.6329 mL
    30 mM 0.1211 mL 0.6055 mL 1.2110 mL 3.0274 mL
    40 mM 0.0908 mL 0.4541 mL 0.9082 mL 2.2706 mL
    50 mM 0.0727 mL 0.3633 mL 0.7266 mL 1.8165 mL
    60 mM 0.0605 mL 0.3027 mL 0.6055 mL 1.5137 mL
    80 mM 0.0454 mL 0.2271 mL 0.4541 mL 1.1353 mL
    100 mM 0.0363 mL 0.1816 mL 0.3633 mL 0.9082 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Sulfamethoxazole sodium Related Classifications

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Sulfamethoxazole4563-84-2Ro 4-2130AntibioticBacterialbacteriostaticantibioticurinarytractpathogenTrimethopriminfectionUTIInhibitorinhibitorinhibit

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