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6-Mercaptopurine

(Synonyms: Mercaptopurine; 6-MP)
18 Cited Publications
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Based on 18 publication(s) in Google Scholar

6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug.

For research use only. We do not sell to patients.

  • Purity: 99.93%
  • CAS No.: 50-44-2
  • Formula: C5H4N4S
  • Molecular Weight:152.18
  • Storage:

    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • 6-Mercaptopurine Chemical Structure
    6-Mercaptopurine Chemical Structure
  • Experimental Validation Results for 6-Mercaptopurine
  • Experimental Validation Results for 6-Mercaptopurine
  • Experimental Validation Results for 6-Mercaptopurine
  • Experimental Validation Results for 6-Mercaptopurine
  • Experimental Validation Results for 6-Mercaptopurine
CAS No.: 50-44-2
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WBIn Vivo Efficacy StudyCell Proliferation/Viability Assay
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  • 6-Mercaptopurine Chemical Structure
    6-Mercaptopurine Chemical Structure
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    6-Mercaptopurine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Dec 4:e2408373. [Abstract]

    Customer Validation
     MM1S cells were treated with 6-Mercaptopurine (6-MP, 1.25-10 µM) or daidzin at the indicated concentrations for 48 h and the expression of CAV1 was detected using western blot. The results showed that 6-MP significantly inhibited the expression of CAV1 protein.

  • 1/16

    6-Mercaptopurine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Dec 4:e2408373. [Abstract]

    Customer Validation
     B‐NDG mice were inoculated with MM1S‐Luc cells and randomly divided into six groups (n = 5–7). After 11 days of inoculation, these mice were intraperitoneally injected with 6-Mercaptopurine (6-MP) (10-20 mg/kg), daidzin (30 mg/kg), or vehicle daily until day 67. After 15 days of inoculation, mice were intraperitoneally injected with bortezomib (0.5 mg/kg) three times a week until day 67. The distribution of MM1S‐Luc cells in these mice was measured at the indicated days after inoculation using a living imaging system.

  • 1/16

    6-Mercaptopurine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Dec 4:e2408373. [Abstract]

    Customer Validation
     B‐NDG mice were inoculated with MM1S‐Luc cells and randomly divided into six groups (n = 5–7). After 11 days of inoculation, these mice were intraperitoneally injected with 6‐MP (10-20 mg/kg), daidzin (30 mg/kg), or vehicle daily until day 67. After 15 days of inoculation, mice were intraperitoneally injected with bortezomib (0.5 mg/kg) three times a week until day 67. Kaplan–Meier curve showing mice survival. The results showed that 6-MP further promoted the bortezomib‐mediated survival of MM‐bearing mice.

  • 1/16

    6-Mercaptopurine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Dec 5:e20444. [Abstract]

    Customer Validation
     Viability of SH‐SY5Y cells treated with 500 µM CuSO4 and 100 µM 6-Mercaptopurine (6-MP) , 400 µM AICAR for 24 h (n = 3, unpaired t‐test).

  • 1/16

    6-Mercaptopurine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Nov 17;13(1):7031. [Abstract]

    Customer Validation
     6-Mercaptopurine (6-MP; 300 µM; pretreatment for 2 h) significantly inhibits EcSTH-induced phosphorylation of AMPK and ACC1 in HeLaTet-on EcSTH and MDA-MB-231Tet-on EcSTH cells.

  • 6-Mercaptopurine