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6-Mercaptopurine

(Synonyms: Mercaptopurine; 6-MP)
18 Cited Publications
Revisión del cliente

Based on 18 publication(s) in Google Scholar

6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug.

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  • Pureza: 99.93%
  • No. CAS: 50-44-2
  • Fòrmula: C5H4N4S
  • Peso molecular:152.18
  • Almacenamiento:

    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • 6-Mercaptopurine Chemical Structure
    6-Mercaptopurine Chemical Structure
  • Experimental Validation Results for 6-Mercaptopurine
  • Experimental Validation Results for 6-Mercaptopurine
  • Experimental Validation Results for 6-Mercaptopurine
  • Experimental Validation Results for 6-Mercaptopurine
  • Experimental Validation Results for 6-Mercaptopurine
No. CAS: 50-44-2
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Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
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  • 6-Mercaptopurine Chemical Structure
    6-Mercaptopurine Chemical Structure
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  • 1/16

    6-Mercaptopurine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Dec 4:e2408373. [Abstract]

    Customer Validation
     MM1S cells were treated with 6-Mercaptopurine (6-MP, 1.25-10 µM) or daidzin at the indicated concentrations for 48 h and the expression of CAV1 was detected using western blot. The results showed that 6-MP significantly inhibited the expression of CAV1 protein.

  • 1/16

    6-Mercaptopurine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Dec 4:e2408373. [Abstract]

    Customer Validation
     B‐NDG mice were inoculated with MM1S‐Luc cells and randomly divided into six groups (n = 5–7). After 11 days of inoculation, these mice were intraperitoneally injected with 6-Mercaptopurine (6-MP) (10-20 mg/kg), daidzin (30 mg/kg), or vehicle daily until day 67. After 15 days of inoculation, mice were intraperitoneally injected with bortezomib (0.5 mg/kg) three times a week until day 67. The distribution of MM1S‐Luc cells in these mice was measured at the indicated days after inoculation using a living imaging system.

  • 1/16

    6-Mercaptopurine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Dec 4:e2408373. [Abstract]

    Customer Validation
     B‐NDG mice were inoculated with MM1S‐Luc cells and randomly divided into six groups (n = 5–7). After 11 days of inoculation, these mice were intraperitoneally injected with 6‐MP (10-20 mg/kg), daidzin (30 mg/kg), or vehicle daily until day 67. After 15 days of inoculation, mice were intraperitoneally injected with bortezomib (0.5 mg/kg) three times a week until day 67. Kaplan–Meier curve showing mice survival. The results showed that 6-MP further promoted the bortezomib‐mediated survival of MM‐bearing mice.

  • 1/16

    6-Mercaptopurine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Dec 5:e20444. [Abstract]

    Customer Validation
     Viability of SH‐SY5Y cells treated with 500 µM CuSO4 and 100 µM 6-Mercaptopurine (6-MP) , 400 µM AICAR for 24 h (n = 3, unpaired t‐test).

  • 1/16

    6-Mercaptopurine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Nov 17;13(1):7031. [Abstract]

    Customer Validation
     6-Mercaptopurine (6-MP; 300 µM; pretreatment for 2 h) significantly inhibits EcSTH-induced phosphorylation of AMPK and ACC1 in HeLaTet-on EcSTH and MDA-MB-231Tet-on EcSTH cells.

  • 6-Mercaptopurine