6-Mercaptopurine-13C2,15N
Based on 1 Customer Validation
6-Mercaptopurine-13C2,15N is the 13C- and 15N-labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.
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- Pureza : 96.0%
- No. CAS: 1190008-04-8
- Fòrmula: C313C2H4N315NS
- Peso molecular:155.16
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Almacenamiento:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Aplicación
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 1190008-04-8
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Unlabeled CAS 50-44-2
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Appearance Solid
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Peso molecular 155.16
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Fòrmula C313C2H4N315NS
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Color White to off-white
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SMILES
SC1=C2[13C](N[13CH]=[15N]2)=NC=N1
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Synonyms
Mercaptopurine-13C2,15N; 6-MP-13C2,15N
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvente y solubilidad
In Vitro:
DMSO : 35.71 mg/mL (230.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Sahasranaman S, et al. Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol. 2008 Aug;64(8):753-67. [Content Brief]
[3]. Liu Q, et al. 6-Mercaptopurine augments glucose transport activity in skeletal muscle cells in part via a mechanism dependent upon orphan nuclear receptor NR4A3. Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1081-92. [Content Brief]
[4]. Kanemitsu H, et al. 6-Mercaptopurine (6-MP) induces cell cycle arrest and apoptosis of neural progenitor cells in the developing fetal rat brain. Neurotoxicol Teratol. 2009 Mar-Apr;31(2):104-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.4450 mL | 32.2248 mL | 64.4496 mL | 161.1240 mL |
| 5 mM | 1.2890 mL | 6.4450 mL | 12.8899 mL | 32.2248 mL | |
| 10 mM | 0.6445 mL | 3.2225 mL | 6.4450 mL | 16.1124 mL | |
| 15 mM | 0.4297 mL | 2.1483 mL | 4.2966 mL | 10.7416 mL | |
| 20 mM | 0.3222 mL | 1.6112 mL | 3.2225 mL | 8.0562 mL | |
| 25 mM | 0.2578 mL | 1.2890 mL | 2.5780 mL | 6.4450 mL | |
| 30 mM | 0.2148 mL | 1.0742 mL | 2.1483 mL | 5.3708 mL | |
| 40 mM | 0.1611 mL | 0.8056 mL | 1.6112 mL | 4.0281 mL | |
| 50 mM | 0.1289 mL | 0.6445 mL | 1.2890 mL | 3.2225 mL | |
| 60 mM | 0.1074 mL | 0.5371 mL | 1.0742 mL | 2.6854 mL | |
| 80 mM | 0.0806 mL | 0.4028 mL | 0.8056 mL | 2.0140 mL | |
| 100 mM | 0.0644 mL | 0.3222 mL | 0.6445 mL | 1.6112 mL |
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