2. Anti-infection Autophagy
  3. Bacterial Autophagy Antibiotic
  4. Colistin sulfate

Colistin (sulfate)  (Synonyms: コリスチン硫酸塩; Polymyxin E (sulfate); ポリミキシンE)

製品番号: HY-A0089 純度: 98.0%
COA 取扱説明書 Technical Support

Colistin sulfate is a polypeptide antibiotic which inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria.

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CAS 番号 : 1264-72-8

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500 mg $96 在庫あり
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Based on 27 publication(s) in Google Scholar

Other Forms of Colistin sulfate:

Colistin (sulfate) 関連抗体

Top Publications Citing Use of Products

    Colistin sulfate purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2025 Jul 7;27(1):137.  [Abstract]

    Colistin sulfate (150 mg/L; 12 weeks). The colonic tissue IF results showed significantly decreased expression of Occludin and, in particular, ZO-1 in the colistin and E. coli groups.

    Colistin sulfate purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2025 Jul 7;27(1):137.  [Abstract]

    Colistin sulfate (150 mg/L; 12 weeks). Significantly decreased mRNA expression of Occludin and ZO-1 was observed in the colistin and E. coli groups compared with the control group.

    Colistin sulfate purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2025 Jul 7;27(1):137.  [Abstract]

    Colistin sulfate (150 mg/L; 12 weeks) was administered. Representative images of H&E, Safranin O, AB, and TB staining of the mice tibial plateau from the three groups at 12 weeks were obtained.

    Colistin sulfate purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2025 Jul 7;27(1):137.  [Abstract]

    Colistin sulfate (150 mg/L; 12 weeks). IFP-SM IF revealed that the expression of CD86 increased in the colistin and E. coli groups.

    Colistin sulfate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 10;15(1):7914.  [Abstract]

    The relative levels of serum anti-OVA IgA, cecal content anti-OVA IgA, serum total IgA, and cecal content total IgA of control (Ctrl) and T. mu-colonized mice with or without NA+ Colistin sulfate (600μg/mouse) treatments were determined 14 days after intraperitoneal immunization.

    Colistin sulfate purchased from MedChemExpress. Usage Cited in: Microorganisms. 2024 Mar 13;12(3):575.

    Percentages of E. coli strains showing antimicrobial resistance to different antimicrobial agents. AMP, Ampicillin; CAZ, Ceftazidime; IPM, Imipenem; MRP, Meropenem; GEN, Gentamicin; OFX, Ofloxacin; SXT, Trimethoprim–sulfamethoxazole; TET, Tetracycline; TGC, Tigecycline; CL, Colistin; FFC, Florfenicol.

    Antibiotic アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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    製品説明

    Colistin sulfate is a polypeptide antibiotic which inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria.

    体外実験

    Colistins are bactericidal to gram-negative bacteria by a detergent-like mechanism. This mechanism involves interaction with lipopolysaccharides and phospholipids of the outer membrane and electrostatic interference with the outer membrane by competitively displacing divalent cations (calcium and magnesium) from the negatively charged phosphate groups of membrane lipids[1]. Colistin (polymyxin E) owns favorable properties of rapid bacterial killing, a narrow spectrum of activity, and an associated slow development of resistance for the treatment of infections caused by multidrug-resistant gram-negative bacteria. There are two forms of colistin available commercially: colistin (sulfate) mainly for topical use and colistin methanesulfonate (sodium) for parenteral use[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Colistin (sulfate) 関連抗体
    体内実験

    High concentrations of colistin in rat ELF are achieved as a result of slow and sustained CMS conversion following i.t. instillation[3]. Colistin is often used in piglets but underdosing and overdosing are frequent. Under- or overdoses of colistin do not result in any major disturbance of piglet fecal microbiota and rarely select for chromosomal resistance in the dominant E. coli population[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    [H][C@@]([C@@H](C)O)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](N1)CCN)=O)CC(C)C)=O)CC(C)C)=O)CCN)=O)CCN)=O)C(NCC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CCC[R])=O)CCN)=O)[C@@H](C)O)=O)CCN)=O)C1=O)=O.[C]C(C)C.[C][C@H](CC)C.O=S(O)(O)=O.[R:].[R:].[Colistin B].[Colistin A].[2.5]
    Structure Classification
    Initial Source

    Bacillus polymyxa var. colistinus
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 50 mg/mL (Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

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    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL; Clear solution; Need ultrasonic

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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 98.0%

    COA (252 KB) HNMR (397 KB) MS (70 KB)

    取扱説明書 (2659 KB)
    参考文献
    動物実験
    [3]

    Rats: Colistin methanesulfonate (sodium) and colistin (sulfate) dosing solutions are freshly prepared in sterile 0.9% sodium chloride. For the i.v. studies, colistin methanesulfonate (CMS) or sulfate solutions are administered by a bolus injection via the jugular vein cannula. Intratracheal (i.t.) instillation is utilized as the technique for pulmonary administration. Animals are administered i.v. CMS at doses of 14 mg/kg of body weight, 28 mg/kg or 56 mg/kg. In an independent study, rats are administered i.v. colistin at doses of 0.21 mg/kg, 0.41 mg/kg, or 0.62 mg/kg[3].

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    参考文献
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    Colistin sulfate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Colistin1264-72-8Polymyxin EBacterialAutophagyAntibioticInhibitorinhibitorinhibit

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    製品名:
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