2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Endogenous Metabolite DNA/RNA Synthesis
  4. Docosanoic acid

Docosanoic acid  (Synonyms: Behenic acid)

Art. -Nr.: HY-W013049 Reinheit: 99.40%
COA
SDS
Handling Instructions Technical Support

Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans.

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Docosanoic acid

Docosanoic acid Chemische Struktur

CAS. Nr. : 112-85-6

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Other Forms of Docosanoic acid:

Docosanoic acid Related Antibodies

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Beschreibung

Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a Kd of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Docosanoic acid is effective at inhibiting the dsDNA binding activity of wild-type p53 DBD, with 50% inhibition observed at 0.41 nmol. The inhibitory effect of Docosanoic acid on the activities of R248A mutant p53 DBD was almost as strong as that of the wild-type[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Docosanoic acid Related Antibodies
In Vivo

In rats, the percentage of Behenic acid in the diet is 1.7% and shows a significant reduction in the deposition of visceral fat, confirmed by a lower weight of adipose (epididymal and mesenteric) and hepatic tissues, as well as excreting more fatty acids in the feces when compared to the group. Behenic acid has a low bioavailability, which leads to a reduction in the absorption and as a consequence, to the reduction in body weight and deposition of visceral fat[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molekulargewicht

340.59

Formel

C22H44O2
CAS. Nr.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CCCCCCCCCCCCCCCCCCCCCC(O)=O
Structure Classification
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit
In Vitro: 

DMF : 9.09 mg/mL (26.69 mM; ultrasonic and warming and heat to 60°C)

DMSO : 1 mg/mL (2.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9361 mL 14.6804 mL 29.3608 mL
5 mM 0.5872 mL 2.9361 mL 5.8722 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  50% PEG300    50% Saline

    Solubility: 3.33 mg/mL (9.78 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 99.40%

SDS (393 KB)

COA (237 KB) HNMR (236 KB) RP-HPLC (248 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMF 1 mM 2.9361 mL 14.6804 mL 29.3608 mL 73.4020 mL
DMF 5 mM 0.5872 mL 2.9361 mL 5.8722 mL 14.6804 mL
10 mM 0.2936 mL 1.4680 mL 2.9361 mL 7.3402 mL
15 mM 0.1957 mL 0.9787 mL 1.9574 mL 4.8935 mL
20 mM 0.1468 mL 0.7340 mL 1.4680 mL 3.6701 mL
25 mM 0.1174 mL 0.5872 mL 1.1744 mL 2.9361 mL
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Docosanoic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Docosanoic acid112-85-6Behenic acidEndogenous MetaboliteDNA/RNA SynthesisInhibitorinhibitorinhibit

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