2. Membrane Transporter/Ion Channel Neuronal Signaling Anti-infection
  3. GABA Receptor HIV
  4. L-Cycloserine

L-Cycloserine  (Synonyms: (S)-Cycloserine; (S)-4-Amino-3-isoxazolidone; L-シクロセリン)

製品番号: HY-B1122 純度: 98.84%
COA 取扱説明書 Technical Support

L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains.

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L-Cycloserine

L-Cycloserine 構造式

CAS 番号 : 339-72-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 41 在庫あり
Solution
10 mM * 1 mL in Water USD 41 在庫あり
Solid
5 mg $38 在庫あり
10 mg $60 在庫あり
50 mg $84 在庫あり
100 mg $120 在庫あり
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Other Forms of L-Cycloserine:

L-Cycloserine 関連抗体

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製品説明

L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains[1][2][3][4].

Cellular Effect
Cell Line Type Value Description References
Splenocyte IC50
3.5 μM
Compound: L-cycloserine
Inhibition of Concanavalin A-stimulated cell proliferation in mouse splenocytes after 48 hrs by MTT assay
Inhibition of Concanavalin A-stimulated cell proliferation in mouse splenocytes after 48 hrs by MTT assay
[PMID: 11000020]
体外実験

L-Cycloserine inhibits the growth of M. tuberculosis, with an MIC of 0.3 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Cycloserine 関連抗体
体内実験

L-Cycloserine (25-50 mg/kg, intraperitoneal injection, single dose) has anticonvulsant effects in mice[2].
L-Cycloserine (30-100 mg/kg, orally or via intraperitoneal injection, twice daily for 5 days) enhances the inhibitory effect on GABA-T activity in mice and boosts its anticonvulsant effects[3].
L-Cycloserine (100-150 mg/kg, subcutaneous or intraperitoneal injection, once daily for 1 week) can reduce the brain content of gangliosides by 28% when injected subcutaneously, with no effect on the content of neurogangliosides; intraperitoneal injection leads to decreased levels of gangliosides and cerebrosides[4].
L-Cycloserine (100 mg/kg, subcutaneous or intraperitoneal injection, single dose) affects the level of inhibition of 3-keto-dihydrosphingosine synthase depending on the method of injection[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Close-crossed epileptic mice (DBA/2J), normal CBNCa mice[2]
Dosage: 25, 50 mg/kg; single dose
Administration: Intraperitoneal injection (i.p.)
Result: Protected mice from seizures three hours later, and the effects gradually weakened thereafter, with lower concentrations of glutamate and aspartate in the hypothalamus decreasing and γ-aminobutyric acid increasing.
Animal Model: DAB/2mice induced by 3-MPA[3]
Dosage: 100 mg/kg; twice a day; 5 days
30 mg/kg; single dose
Administration: Oral; Intraperitoneal injection (i.p.)
Result: Enhanced inhibition of GABA-T activity protected mice from 3-mercaptopropionic acid (3-MPA)-induced tonic seizures, and motor performance deficits decreased over time.
Animal Model: Male Swiss mice[4]
Dosage: 100 mg/kg; single dose
Administration: Subcutaneous injection (s.c.); Intraperitoneal injection (i.p.)
Result: Showed that 2 hours after intraperitoneal injection, the synthase activity was found to be inhibited by 80%, and subcutaneous injection of L-cycloserine had no significant inhibitory effect on the synthase within 2-48 hours.
分子量

102.09

分子式

C3H6N2O2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C1NOC[C@@H]1N
Structure Classification
Initial Source

Erwinia uredovora.
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : 100 mg/mL (979.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.7953 mL 48.9764 mL 97.9528 mL
5 mM 1.9591 mL 9.7953 mL 19.5906 mL
10 mM 0.9795 mL 4.8976 mL 9.7953 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 9.7953 mL 48.9764 mL 97.9528 mL 244.8820 mL
5 mM 1.9591 mL 9.7953 mL 19.5906 mL 48.9764 mL
10 mM 0.9795 mL 4.8976 mL 9.7953 mL 24.4882 mL
15 mM 0.6530 mL 3.2651 mL 6.5302 mL 16.3255 mL
20 mM 0.4898 mL 2.4488 mL 4.8976 mL 12.2441 mL
25 mM 0.3918 mL 1.9591 mL 3.9181 mL 9.7953 mL
30 mM 0.3265 mL 1.6325 mL 3.2651 mL 8.1627 mL
40 mM 0.2449 mL 1.2244 mL 2.4488 mL 6.1220 mL
50 mM 0.1959 mL 0.9795 mL 1.9591 mL 4.8976 mL
60 mM 0.1633 mL 0.8163 mL 1.6325 mL 4.0814 mL
80 mM 0.1224 mL 0.6122 mL 1.2244 mL 3.0610 mL
100 mM 0.0980 mL 0.4898 mL 0.9795 mL 2.4488 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Cycloserine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Cycloserine339-72-0(S)-Cycloserine (S)-4-Amino-3-isoxazolidoneGABA ReceptorHIVGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorHuman immunodeficiency virusBrain cerebroside synthesisanticonvulsantMycobacterium tuberculosis branched-chain aminotransferasegamma-aminobutyric acid (GABA)-aminotransferaseInhibitorinhibitorinhibit

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製品名:
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製品番号:
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