2. Others Apoptosis Neuronal Signaling Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. Ferroptosis Environmental Pollutants Endogenous Metabolite Apoptosis iGluR
  4. L-Glutamic acid monosodium salt

L-Glutamic acid (monosodium salt)  (Synonyms: L-グルタミン酸一ナトリウム)

製品番号: HY-14608A 純度: 98.0%
COA 取扱説明書 Technical Support

L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases. L-Glutamic acid monosodium salt acts at ionotropic and metabotropic glutamate receptors.

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CAS 番号 : 142-47-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in Water USD 27 在庫あり
Solid
100 mg $25 在庫あり
500 mg $32 在庫あり
1 g $39 在庫あり
5 g $50 在庫あり
10 g   お問い合わせ  
50 g   お問い合わせ  

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カスタマーレビュー

Based on 14 publication(s) in Google Scholar

Other Forms of L-Glutamic acid monosodium salt:

L-Glutamic acid (monosodium salt) 関連抗体

Top Publications Citing Use of Products

    L-Glutamic acid monosodium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 5:e11194.  [Abstract]

    L-Glutamic acid (100 µM; 10 min) for activation of spike count. Spontaneous LFP activity is recorded from OPAB that has been pre-treated with Bicuculline and stimulated with L-Glutamic acid. The LFP signal from the activated OPAB is measured (pre), and then the electrical signal is inhibited for 10 min using a cocktail of TTX, CNQX, and AP5 and LFP was recorded again (post).

    L-Glutamic acid monosodium salt purchased from MedChemExpress. Usage Cited in: Cancer Immunol Immunother. 2025 Jun 7;74(8):240.  [Abstract]

    Flow cytometry representative image showing the effect of exogenous glutamate (1 mM) on mouse primary T cells.

    L-Glutamic acid monosodium salt purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Jan 27:18:1235-1254.  [Abstract]

    Viability of HT22 cells treated with Glutamate at different concentrations (0, 5, 10, 15, 20 and 25 mM) for 24 h (n=5 at each concentration).

    L-Glutamic acid monosodium salt purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Jan 27:18:1235-1254.  [Abstract]

    The relative mRNA expression levels of c-fos in the control, glu (20 mM, 24 h) and lactate groups (n=6 in each group).

    L-Glutamic acid monosodium salt purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Jan 27:18:1235-1254.  [Abstract]

    Fluorescence images of TUNEL staining of HT22 cells in the control, glu (20 mM, 24 h) and lactate groups.

    L-Glutamic acid monosodium salt purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Jan 27:18:1235-1254.  [Abstract]

    Images of VGLUT1 fluorescence staining in HT22 cells from the control, glu (20 mM, 24 h) and lactate groups.

    L-Glutamic acid monosodium salt purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Feb 18;22(1):178.  [Abstract]

    PC3 and DU145 cells were treated with 10 μM glutamate for 24 h, after which the protein expression levels were analysed by western blotting. The expression intensity was normalized to that of β-tubulin (right panel).

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    iGluR アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    AMPA Receptor NMDA Receptor Kainate Receptor

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases. L-Glutamic acid monosodium salt acts at ionotropic and metabotropic glutamate receptors[1][2][3][4][5].

    IC50 & Target

    Microbial Metabolite

     

    AMPA Receptor

     

    Human Endogenous Metabolite

     

    体外実験

    L-Glutamic acid monosodium salt (120, 500, 750, 1000 mg/dL) can reduce the harmful effect of lithium on the embryonic development of Xenopus Xenopus[3].
    L-Glutamic acid monosodium salt (2, 5, 10, 20 mM, 24-48 h) can induce neuroexcitotoxicity in neuroblastoma[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    L-Glutamic acid (monosodium salt) 関連抗体

    Cell Viability Assay[4]

    Cell Line: SH-SY5Y, IMR-32, SK-N-BE(2)
    Concentration: 2, 5, 10, 20 mM
    Incubation Time: 24 and 48 h
    Result: Reduced cell viability in a dose-dependent manner.
    体内実験

    L-Glutamic acid monosodium salt (3 g/kg, subcutaneous injection) can promote excitotoxic degeneration of retinal ganglion cells in mice[1].
    L-Glutamic acid monosodium salt (750 mg/kg, intraperitoneal injection) can reduce and inhibit oxidative stress induced by chlorpyrifos (CPF) in rats[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Crv4 mice model[1]
    Dosage: 3g/kg
    Administration: s.c., single dose
    Result: Reduced the number of Brn-3a+ RGCs by >70%.
    In the absence of mGlu1 receptor, MSG-induced retinal damage is diminished.
    Animal Model: CPF-induced rat model[5]
    Dosage: 750 mg/kg
    Administration: i.p.
    Result: Reduced CPF-induced oxidative stress by increasing the level of GSH and activity of GSH-related enzymes.
    分子量

    169.11

    分子式

    C5H8NNaO4
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O[Na])CC[C@H](N)C(O)=O
    Structure Classification
    Initial Source

    mammalian brain
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 100 mg/mL (591.33 mM; Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.9133 mL 29.5666 mL 59.1331 mL
    5 mM 1.1827 mL 5.9133 mL 11.8266 mL
    10 mM 0.5913 mL 2.9567 mL 5.9133 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (591.33 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 98.0%

    COA (252 KB) HNMR (239 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 5.9133 mL 29.5666 mL 59.1331 mL 147.8328 mL
    5 mM 1.1827 mL 5.9133 mL 11.8266 mL 29.5666 mL
    10 mM 0.5913 mL 2.9567 mL 5.9133 mL 14.7833 mL
    15 mM 0.3942 mL 1.9711 mL 3.9422 mL 9.8555 mL
    20 mM 0.2957 mL 1.4783 mL 2.9567 mL 7.3916 mL
    25 mM 0.2365 mL 1.1827 mL 2.3653 mL 5.9133 mL
    30 mM 0.1971 mL 0.9856 mL 1.9711 mL 4.9278 mL
    40 mM 0.1478 mL 0.7392 mL 1.4783 mL 3.6958 mL
    50 mM 0.1183 mL 0.5913 mL 1.1827 mL 2.9567 mL
    60 mM 0.0986 mL 0.4928 mL 0.9856 mL 2.4639 mL
    80 mM 0.0739 mL 0.3696 mL 0.7392 mL 1.8479 mL
    100 mM 0.0591 mL 0.2957 mL 0.5913 mL 1.4783 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    L-Glutamic acid monosodium salt Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-Glutamic acid monosodium142-47-2FerroptosisEnvironmental PollutantsEndogenous MetaboliteApoptosisiGluREnvironmental ContaminantsIonotropic glutamate receptorsNMDAAgonistSH-SY5YIMR-32SK-N-BE(2)NeurotoxicityCrv4 miceInhibitorinhibitorinhibit

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    製品名:
    L-Glutamic acid monosodium salt
    製品番号:
    HY-14608A
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