Quinine

Name: Quinine
Brand: MedChemExpress
SKU: HY-D0143
Rating: 5.0 (7 reviews)

Cat. No.: HY-D0143 Purity: 99.82%: Data Sheet
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Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM.

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Quinine 화학구조

CAS No. : 130-95-0

사이즈	재고	수량
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	해외재고보유	Estimated Time of Arrival: December 31
10 g	해외재고보유	Estimated Time of Arrival: December 31
25 g	해외재고보유	Estimated Time of Arrival: December 31
50 g	견적 받기

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고객리뷰

Based on 7 publication(s) in Google Scholar

Other Forms of Quinine:

Quinine-d₃ In-stock
Quinine (hydrochloride) In-stock
Quinine hydrochloride dihydrate In-stock
Quinine sulfate In-stock
Quinine dihydrochloride In-stock
Quinine hemisulfate hydrate In-stock
Quinine sulfate hydrate In-stock
Quinine hemisulfate 견적 받기
Quinine hydrobromide 견적 받기
Quinine (Standard) 견적 받기

7 Publications Citing Use of MCE Quinine

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

Plasmodium

Cellular Effect

Cell Line	Type	Value	Description	References
5637	IC₅₀	>50 3 Compound: 2	Cytotoxicity against human 5637 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human 5637 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23707051]
5637	IC₅₀	> 50 3 Compound: 2	Cytotoxicity against human 5637 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human 5637 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23707051]
5637	IC₅₀	> 50 3 Compound: 2	Cytotoxicity against human 5637 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human 5637 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23707051]
A-431	ED₅₀	> 20 6 Compound: quinine	Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
A-431	ED₅₀	>20 6 Compound: quinine	Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
A-431	ED₅₀	> 20 6 Compound: quinine	Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
EJ	IC₅₀	>50 3 Compound: 2	Cytotoxicity against human EJ cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human EJ cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23707051]
EJ	IC₅₀	> 50 3 Compound: 2	Cytotoxicity against human EJ cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human EJ cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23707051]
EJ	IC₅₀	> 50 3 Compound: 2	Cytotoxicity against human EJ cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human EJ cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23707051]
FM3A	EC₅₀	100 3 Compound: quinine	Cytotoxicity against mouse FM3A cell line Cytotoxicity against mouse FM3A cell line	[PMID: 16524728]
HEK293	IC₅₀	134.35 3 Compound: Quinine	Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay	[PMID: 33744688]
HEK293	IC₅₀	275.6 3 Compound: Quinine	Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay	[PMID: 28027871]
FM3A	EC₅₀	0.1 2 Compound: Quinine	Cytotoxicity against mouse mammary tumor FM3A cells representing a model of host Cytotoxicity against mouse mammary tumor FM3A cells representing a model of host	[PMID: 11855978]
FM3A	EC₅₀	0.1 2 Compound: Quinine	In vitro cytotoxic activity against mouse mammary tumor FM3A cells In vitro cytotoxic activity against mouse mammary tumor FM3A cells	[PMID: 10937718]
HEK293	IC₅₀	51.6 3 Compound: quinine	Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy	[PMID: 18788725]
FM3A	EC₅₀	0.1 2 Compound: Quinine	In vitro cytotoxic activity tested in mouse mammary tumor FM3A cells In vitro cytotoxic activity tested in mouse mammary tumor FM3A cells	[PMID: 15026051]
HeLa	IC₅₀	> 50 3 Compound: 2	Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23707051]
FM3A	EC₅₀	0.0001 41 Compound: Quinine	In vitro cytotoxic activity against mouse mammary tumor FM3A cells In vitro cytotoxic activity against mouse mammary tumor FM3A cells	[PMID: 10937718]
HEK293	IC₅₀	275.6 3 Compound: Quinine	Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay	[PMID: 28027871]
HepG2	CC₅₀	> 100 3 Compound: 3	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue assay	[PMID: 30779564]
FM3A	EC₅₀	0.0001 41 Compound: Quinine	Cytotoxicity against mouse mammary tumor FM3A cells representing a model of host Cytotoxicity against mouse mammary tumor FM3A cells representing a model of host	[PMID: 11855978]
HEK293	IC₅₀	134.35 3 Compound: Quinine	Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay	[PMID: 33744688]
HT-1080	ED₅₀	> 20 6 Compound: quinine	Cytotoxicity against human HT1080 cells after 3 days by sulforhodamine B assay Cytotoxicity against human HT1080 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
HEK293	IC₅₀	51.6 3 Compound: quinine	Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy	[PMID: 18788725]
Jurkat	IC₅₀	> 50 3 Compound: 2	Cytotoxicity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23707051]
FM3A	EC₅₀	0.0001 41 Compound: Quinine	In vitro cytotoxic activity tested in mouse mammary tumor FM3A cells In vitro cytotoxic activity tested in mouse mammary tumor FM3A cells	[PMID: 15026051]
KB	ED₅₀	> 20 6 Compound: quinine	Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
FM3A	EC₅₀	100000 1 Compound: quinine	Cytotoxicity against mouse FM3A cell line Cytotoxicity against mouse FM3A cell line	[PMID: 16524728]
HEK293	IC₅₀	1.1 3 Compound: Quinine	TP_TRANSPORTER: inhibition of TEA uptake (in the absence of bicarbonate) (TEA: 20 uM) in OCT1-expressing HEK293 cells TP_TRANSPORTER: inhibition of TEA uptake (in the absence of bicarbonate) (TEA: 20 uM) in OCT1-expressing HEK293 cells	[PMID: 12438515]
HEK293	IC₅₀	38 3 Compound: Quinine	TP_TRANSPORTER: inhibition of TEA uptake (in the absence of bicarbonate) (TEA: 20 uM) in OCT2-expressing HEK293 cells TP_TRANSPORTER: inhibition of TEA uptake (in the absence of bicarbonate) (TEA: 20 uM) in OCT2-expressing HEK293 cells	[PMID: 12438515]
KB	ED₅₀	> 20 6 Compound: quinine	Cytotoxicity against human KB cells after 72 hrs Cytotoxicity against human KB cells after 72 hrs	[PMID: 11421741]
KB	ED₅₀	> 55400 1 Compound: quinine	Cytotoxicity against human KB cells after 72 hrs by SRB assay Cytotoxicity against human KB cells after 72 hrs by SRB assay	[PMID: 9917283]
HEK293	IC₅₀	0.9 3 Compound: Quinine	TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT1-expressing HEK293 cells TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT1-expressing HEK293 cells	[PMID: 12438515]
HEK293	IC₅₀	13 3 Compound: Quinine	TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT2-expressing HEK293 cells TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT2-expressing HEK293 cells	[PMID: 12438515]
KB-V1	ED₅₀	5.6 6 Compound: quinine	Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
LNCaP	ED₅₀	> 20 6 Compound: quinine	Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
HeLa	IC₅₀	>50 3 Compound: 2	Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23707051]
Hepatocyte	IC₅₀	150 3 Compound: 11 Quinine	Inhibition of apamin-sensitive SKCa channel of guinea-pig hepatocytes Inhibition of apamin-sensitive SKCa channel of guinea-pig hepatocytes	[PMID: 15225721]
MES-SA	IC₅₀	91 3 Compound: 2; Q	Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 144 hrs in presence of P-gp inhibitor Tariquidar by fluorescence microplate reader assay Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 144 hrs in presence of P-gp inhibitor Tariquidar by fluorescence microplate reader assay	[PMID: 35640378]
HepG2	CC₅₀	>100 3 Compound: 3	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue assay	[PMID: 30779564]
MES-SA	IC₅₀	93 3 Compound: 2; Q	Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 144 hrs by fluorescence microplate reader assay Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 144 hrs by fluorescence microplate reader assay	[PMID: 35640378]
HT-1080	ED₅₀	>20 6 Compound: quinine	Cytotoxicity against human HT1080 cells after 3 days by sulforhodamine B assay Cytotoxicity against human HT1080 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
MES-SA/Dx5	IC₅₀	43 3 Compound: 2; Q	Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 144 hrs in presence of P-gp inhibitor Tariquidar by fluorescence microplate reader assay Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 144 hrs in presence of P-gp inhibitor Tariquidar by fluorescence microplate reader assay	[PMID: 35640378]
Huh-7	CC₅₀	>6.25 3 Compound: GNF-Pf-180	NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)	[PMID: 18579783]
MES-SA/Dx5	IC₅₀	67 3 Compound: 2; Q	Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 144 hrs by fluorescence microplate reader assay Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 144 hrs by fluorescence microplate reader assay	[PMID: 35640378]
Jurkat	IC₅₀	>50 3 Compound: 2	Cytotoxicity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23707051]
P388	ED₅₀	> 5 6 Compound: quinine	Cytotoxicity against mouse P388 cells after 2 days by sulforhodamine B assay Cytotoxicity against mouse P388 cells after 2 days by sulforhodamine B assay	[PMID: 8450319]
KB	ED₅₀	>20 6 Compound: quinine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 16933872]
PC-3	IC₅₀	> 50 3 Compound: 2	Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23707051]
KB	ED₅₀	>20 6 Compound: quinine	Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
SK-MEL-2	ED₅₀	> 20 6 Compound: quinine	Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
KB	ED₅₀	>20 6 Compound: quinine	Cytotoxicity against human KB cells after 72 hrs Cytotoxicity against human KB cells after 72 hrs	[PMID: 11421741]
WI-38	IC₅₀	20.25 3 Compound: QN	Cytotoxicity against human WI38 cells by MTT assay Cytotoxicity against human WI38 cells by MTT assay	[PMID: 26063305]
KB	IC₅₀	>20000 14 Compound: Quinine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 8759172]
WI-38	IC₅₀	6.56 6 Compound: 1a	Cytotoxicity against human WI38 cells by MTT assay Cytotoxicity against human WI38 cells by MTT assay	[PMID: 23816880]
HEK293	IC₅₀	0.9 3 Compound: Quinine	TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT1-expressing HEK293 cells TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT1-expressing HEK293 cells	[PMID: 12438515]
KB	IC₅₀	>20000 14 Compound: quinine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 1294700]
HEK293	IC₅₀	1.1 3 Compound: Quinine	TP_TRANSPORTER: inhibition of TEA uptake (in the absence of bicarbonate) (TEA: 20 uM) in OCT1-expressing HEK293 cells TP_TRANSPORTER: inhibition of TEA uptake (in the absence of bicarbonate) (TEA: 20 uM) in OCT1-expressing HEK293 cells	[PMID: 12438515]
ZR-75-1	ED₅₀	1.2 6 Compound: quinine	Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
HEK293	IC₅₀	13 3 Compound: Quinine	TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT2-expressing HEK293 cells TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT2-expressing HEK293 cells	[PMID: 12438515]
KB	IC₅₀	>20000 14 Compound: quinine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 9134742]
HEK293	IC₅₀	134.35 3 Compound: Quinine	Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay	[PMID: 33744688]
KB-V1	ED₅₀	5.6 6 Compound: quinine	Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
KB-V1	ED₅₀	>20 6 Compound: quinine	Cytotoxicity against human multidrug-resistant KBV1 cells Cytotoxicity against human multidrug-resistant KBV1 cells	[PMID: 8450318]
HEK293	IC₅₀	275.6 3 Compound: Quinine	Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay	[PMID: 28027871]
LNCaP	ED₅₀	>20 6 Compound: quinine	Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
HEK293	IC₅₀	38 3 Compound: Quinine	TP_TRANSPORTER: inhibition of TEA uptake (in the absence of bicarbonate) (TEA: 20 uM) in OCT2-expressing HEK293 cells TP_TRANSPORTER: inhibition of TEA uptake (in the absence of bicarbonate) (TEA: 20 uM) in OCT2-expressing HEK293 cells	[PMID: 12438515]
MES-SA	IC₅₀	93 3 Compound: 2; Q	Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 144 hrs by fluorescence microplate reader assay Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 144 hrs by fluorescence microplate reader assay	[PMID: 35640378]
HEK293	IC₅₀	51.6 3 Compound: quinine	Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy	[PMID: 18788725]
MES-SA	IC₅₀	91 3 Compound: 2; Q	Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 144 hrs in presence of P-gp inhibitor Tariquidar by fluorescence microplate reader assay Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 144 hrs in presence of P-gp inhibitor Tariquidar by fluorescence microplate reader assay	[PMID: 35640378]
MES-SA/Dx5	IC₅₀	67 3 Compound: 2; Q	Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 144 hrs by fluorescence microplate reader assay Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 144 hrs by fluorescence microplate reader assay	[PMID: 35640378]
MES-SA/Dx5	IC₅₀	43 3 Compound: 2; Q	Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 144 hrs in presence of P-gp inhibitor Tariquidar by fluorescence microplate reader assay Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 144 hrs in presence of P-gp inhibitor Tariquidar by fluorescence microplate reader assay	[PMID: 35640378]
NIH-3T3-G185	IC₅₀	167.8 3 Compound: Quinine	TP_TRANSPORTER: inhibition of Calcein-AM efflux in NIH-3T3-G185 cells TP_TRANSPORTER: inhibition of Calcein-AM efflux in NIH-3T3-G185 cells	[PMID: 11716514]
NIH-3T3-G185	IC₅₀	22.6 3 Compound: Quinine	TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells	[PMID: 11716514]
NIH-3T3-G185	IC₅₀	112.4 3 Compound: Quinine	TP_TRANSPORTER: inhibition of Fluo-3-AM efflux in NIH-3T3-G185 cells TP_TRANSPORTER: inhibition of Fluo-3-AM efflux in NIH-3T3-G185 cells	[PMID: 11716514]
HT-1080	ED₅₀	> 20 6 Compound: quinine	Cytotoxicity against human HT1080 cells after 3 days by sulforhodamine B assay Cytotoxicity against human HT1080 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
HeLa	IC₅₀	> 50 3 Compound: 2	Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23707051]
NIH-3T3-G185	IC₅₀	159.3 3 Compound: Quinine	TP_TRANSPORTER: inhibition of JC-1 efflux in NIH-3T3-G185 cells TP_TRANSPORTER: inhibition of JC-1 efflux in NIH-3T3-G185 cells	[PMID: 11716514]
NIH-3T3-G185	IC₅₀	74.4 3 Compound: Quinine	TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells	[PMID: 11716514]
NIH-3T3-G185	IC₅₀	87.6 3 Compound: Quinine	TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells	[PMID: 11716514]
HepG2	CC₅₀	> 100 3 Compound: 3	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by Alamar Blue assay	[PMID: 30779564]
NIH-3T3-G185	IC₅₀	184.9 3 Compound: Quinine	TP_TRANSPORTER: inhibition of Tetramethylrosamine efflux in NIH-3T3-G185 cells TP_TRANSPORTER: inhibition of Tetramethylrosamine efflux in NIH-3T3-G185 cells	[PMID: 11716514]
Hepatocyte	IC₅₀	150 3 Compound: 11 Quinine	Inhibition of apamin-sensitive SKCa channel of guinea-pig hepatocytes Inhibition of apamin-sensitive SKCa channel of guinea-pig hepatocytes	[PMID: 15225721]
Huh-7	CC₅₀	> 6.25 3 Compound: GNF-Pf-180	NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)	[PMID: 18579783]
Oocyte	IC₅₀	0.28 3 Compound: Quinine	TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes	[PMID: 12176030]
Oocyte	IC₅₀	2.8 3 Compound: Quinine	TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes	[PMID: 12176030]
Jurkat	IC₅₀	> 50 3 Compound: 2	Cytotoxicity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human Jurkat cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23707051]
Oocyte	IC₅₀	4.1 3 Compound: Quinine	TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes	[PMID: 11502595]
KB	ED₅₀	> 20 6 Compound: quinine	Cytotoxicity against human KB cells after 72 hrs Cytotoxicity against human KB cells after 72 hrs	[PMID: 11421741]
KB	ED₅₀	> 20 6 Compound: quinine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 16933872]
P388	ED₅₀	>5 6 Compound: quinine	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 8450318]
P388	ED₅₀	>5 6 Compound: quinine	Cytotoxicity against mouse P388 cells after 2 days by sulforhodamine B assay Cytotoxicity against mouse P388 cells after 2 days by sulforhodamine B assay	[PMID: 8450319]
KB	ED₅₀	> 20 6 Compound: quinine	Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
PC-3	IC₅₀	>50 3 Compound: 2	Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23707051]
KB	ED₅₀	> 55400 1 Compound: quinine	Cytotoxicity against human KB cells after 72 hrs by SRB assay Cytotoxicity against human KB cells after 72 hrs by SRB assay	[PMID: 9917283]
ScN2a	IC₅₀	10 3 Compound: quinine	Antiprion activity in ScN2a cells assessed as inhibition of protease-resistant prion protein accumulation Antiprion activity in ScN2a cells assessed as inhibition of protease-resistant prion protein accumulation	[PMID: 17850126]
KB	IC₅₀	> 20000 14 Compound: Quinine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 8759172]
KB	IC₅₀	> 20000 14 Compound: quinine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 1294700]
SK-MEL-2	ED₅₀	>20 6 Compound: quinine	Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
WI-38	IC₅₀	20.25 3 Compound: QN	Cytotoxicity against human WI38 cells by MTT assay Cytotoxicity against human WI38 cells by MTT assay	[PMID: 26063305]
KB	IC₅₀	> 20000 14 Compound: quinine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 9134742]
KB-V1	ED₅₀	5.6 6 Compound: quinine	Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
WI-38	IC₅₀	6.56 6 Compound: 1a	Cytotoxicity against human WI38 cells by MTT assay Cytotoxicity against human WI38 cells by MTT assay	[PMID: 23816880]
KB	ED₅₀	>55400 1 Compound: quinine	Cytotoxicity against human KB cells after 72 hrs by SRB assay Cytotoxicity against human KB cells after 72 hrs by SRB assay	[PMID: 9917283]
KB-V1	ED₅₀	> 20 6 Compound: quinine	Cytotoxicity against human multidrug-resistant KBV1 cells Cytotoxicity against human multidrug-resistant KBV1 cells	[PMID: 8450318]
ZR-75-1	ED₅₀	1.2 6 Compound: quinine	Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
LNCaP	ED₅₀	> 20 6 Compound: quinine	Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
MES-SA	IC₅₀	91 3 Compound: 2; Q	Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 144 hrs in presence of P-gp inhibitor Tariquidar by fluorescence microplate reader assay Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 144 hrs in presence of P-gp inhibitor Tariquidar by fluorescence microplate reader assay	[PMID: 35640378]
MES-SA	IC₅₀	93 3 Compound: 2; Q	Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 144 hrs by fluorescence microplate reader assay Cytotoxicity against human MES-SA cells assessed as cell growth inhibition incubated for 144 hrs by fluorescence microplate reader assay	[PMID: 35640378]
MES-SA/Dx5	IC₅₀	43 3 Compound: 2; Q	Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 144 hrs in presence of P-gp inhibitor Tariquidar by fluorescence microplate reader assay Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 144 hrs in presence of P-gp inhibitor Tariquidar by fluorescence microplate reader assay	[PMID: 35640378]
MES-SA/Dx5	IC₅₀	67 3 Compound: 2; Q	Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 144 hrs by fluorescence microplate reader assay Cytotoxicity against multidrug resistance human MES-SA/Dx5 cells assessed as cell growth inhibition incubated for 144 hrs by fluorescence microplate reader assay	[PMID: 35640378]
NIH-3T3-G185	IC₅₀	112.4 3 Compound: Quinine	TP_TRANSPORTER: inhibition of Fluo-3-AM efflux in NIH-3T3-G185 cells TP_TRANSPORTER: inhibition of Fluo-3-AM efflux in NIH-3T3-G185 cells	[PMID: 11716514]
NIH-3T3-G185	IC₅₀	159.3 3 Compound: Quinine	TP_TRANSPORTER: inhibition of JC-1 efflux in NIH-3T3-G185 cells TP_TRANSPORTER: inhibition of JC-1 efflux in NIH-3T3-G185 cells	[PMID: 11716514]
NIH-3T3-G185	IC₅₀	167.8 3 Compound: Quinine	TP_TRANSPORTER: inhibition of Calcein-AM efflux in NIH-3T3-G185 cells TP_TRANSPORTER: inhibition of Calcein-AM efflux in NIH-3T3-G185 cells	[PMID: 11716514]
NIH-3T3-G185	IC₅₀	184.9 3 Compound: Quinine	TP_TRANSPORTER: inhibition of Tetramethylrosamine efflux in NIH-3T3-G185 cells TP_TRANSPORTER: inhibition of Tetramethylrosamine efflux in NIH-3T3-G185 cells	[PMID: 11716514]
NIH-3T3-G185	IC₅₀	22.6 3 Compound: Quinine	TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells	[PMID: 11716514]
NIH-3T3-G185	IC₅₀	74.4 3 Compound: Quinine	TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells	[PMID: 11716514]
NIH-3T3-G185	IC₅₀	87.6 3 Compound: Quinine	TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells	[PMID: 11716514]
Oocyte	IC₅₀	0.28 3 Compound: Quinine	TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes	[PMID: 12176030]
Oocyte	IC₅₀	2.8 3 Compound: Quinine	TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes	[PMID: 12176030]
Oocyte	IC₅₀	4.1 3 Compound: Quinine	TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes	[PMID: 11502595]
P388	ED₅₀	> 5 6 Compound: quinine	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 8450318]
P388	ED₅₀	> 5 6 Compound: quinine	Cytotoxicity against mouse P388 cells after 2 days by sulforhodamine B assay Cytotoxicity against mouse P388 cells after 2 days by sulforhodamine B assay	[PMID: 8450319]
PC-3	IC₅₀	> 50 3 Compound: 2	Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23707051]
SK-MEL-2	ED₅₀	> 20 6 Compound: quinine	Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]
ScN2a	IC₅₀	10 3 Compound: quinine	Antiprion activity in ScN2a cells assessed as inhibition of protease-resistant prion protein accumulation Antiprion activity in ScN2a cells assessed as inhibition of protease-resistant prion protein accumulation	[PMID: 17850126]
WI-38	IC₅₀	20.25 3 Compound: QN	Cytotoxicity against human WI38 cells by MTT assay Cytotoxicity against human WI38 cells by MTT assay	[PMID: 26063305]
WI-38	IC₅₀	6.56 6 Compound: 1a	Cytotoxicity against human WI38 cells by MTT assay Cytotoxicity against human WI38 cells by MTT assay	[PMID: 23816880]
ZR-75-1	ED₅₀	1.2 6 Compound: quinine	Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay	[PMID: 8450319]

In Vitro

Quinine (150 μM, 30 min) inhibits the proliferation and cytostatic effects of DENV (Dengue virus) in human hepatocarcinoma HepG2 cell line^[1].
Quinine (37.5-150 μM, 24 hours) significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in human hepatocarcinoma HepG2 cell line^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	Human hepatocarcinoma cell line (HepG2)
Concentration:	150 μM
Incubation Time:	30 min
Result:	Inhibited DENV virus replication with 19% yield compared to untreated. Reduced DENV-positive cells from 23.28% to 12.05% in a dose-dependent manner.

In Vivo

Quinine (oral gavage, 12 or 15 mg/kg, every week, 16 weeks) has some tumor suppressing effect on skin cancer in Swiss albino mice^[2].
Quinine (oral gavage, 10 mg/kg, everyday, 8 weeks) causes a decrease in the antioxidant defense system of rat testicular tissue such as SOD, CAT and GSH enzyme activity in male adult albino rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss albino mice 7-8-weeks (weighing 24 g)^[2]
Dosage:	12 mg/kg, 15 mg/kg
Administration:	Oral gavage; every week; 16 weeks
Result:	Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg.

분자량

324.42

화학식

C₂₀H₂₄N₂O₂

CAS No.

130-95-0

Appearance

Solid

Color

White to off-white

SMILES

O[C@H](C1=CC=NC2=C1C=C(OC)C=C2)[C@@]3([H])[N@](C[C@@H]4C=C)CC[C@H]4C3

Structure Classification

Initial Source

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

용액&용해도

In Vitro:

DMSO : ≥ 100 mg/mL (308.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0824 mL	15.4121 mL	30.8242 mL
5 mM	0.6165 mL	3.0824 mL	6.1648 mL
10 mM	0.3082 mL	1.5412 mL	3.0824 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 99.82%

Select Batch:

Data Sheet (283 KB) SDS (394 KB)

COA (255 KB) HNMR (257 KB) RP-HPLC (221 KB) MS (179 KB)

Handling Instructions (2659 KB)

References

[1]. Jhanwar, Deepika，et al. Chemoprevention of DMBA induced skin carcinogenesis in swiss albino mice by quinine sulfate.(2016): 2636-2640.

[2]. Shilu Malakar，et al. Drug repurposing of quinine as antiviral against dengue virus infection. Virus Res. 2018 Aug 15;255:171-178. doi: 10.1016/j.virusres.2018.07.018. Epub 2018 Jul 25. [Content Brief]

[3]. Ebenezer O Farombi, et al. Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of quinine sulfate in rats. J Basic Clin Physiol Pharmacol. 2012 Feb 27;23(1):39-44. [Content Brief]

[4]. Jane Achan , et al. Quinine, an Old Anti-Malarial Drug in a Modern World: Role in the Treatment of Malaria. Malar J. 2011 May 24;10:144. [Content Brief]

[5]. Wrighton DC, et al. Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium. Br J Pharmacol. 2015 Sep;172(17):4355-63. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0824 mL	15.4121 mL	30.8242 mL	77.0606 mL
	5 mM	0.6165 mL	3.0824 mL	6.1648 mL	15.4121 mL
	10 mM	0.3082 mL	1.5412 mL	3.0824 mL	7.7061 mL
	15 mM	0.2055 mL	1.0275 mL	2.0549 mL	5.1374 mL
	20 mM	0.1541 mL	0.7706 mL	1.5412 mL	3.8530 mL
	25 mM	0.1233 mL	0.6165 mL	1.2330 mL	3.0824 mL
	30 mM	0.1027 mL	0.5137 mL	1.0275 mL	2.5687 mL
	40 mM	0.0771 mL	0.3853 mL	0.7706 mL	1.9265 mL
	50 mM	0.0616 mL	0.3082 mL	0.6165 mL	1.5412 mL
	60 mM	0.0514 mL	0.2569 mL	0.5137 mL	1.2843 mL
	80 mM	0.0385 mL	0.1927 mL	0.3853 mL	0.9633 mL
	100 mM	0.0308 mL	0.1541 mL	0.3082 mL	0.7706 mL

Quinine Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinine130-95-0Dengue VirusFlavivirusParasitePotassium ChannelDENVKcsAanti-malariaparasitepotassiumchannelKCa5.1Slo3Inhibitorinhibitorinhibit

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Quinine

고객리뷰

Other Forms of Quinine:

Quinine Related Antibodies

7 Publications Citing Use of MCE Quinine

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Biological Activity

순도&문서

References

고객리뷰

Quinine Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Quinine Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

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