Quinine hemisulfate hydrate
Based on 7 publication(s) in Google Scholar
Quinine hemisulfate hydrate is an orally active alkaloid extracted from cinchona bark, possessing various biological activities including antimalarial, antidengue virus (DENV), and anticancer properties. Quinine hemisulfate hydrate acts as a potassium channel inhibitor that suppresses the +100 mV current of MT mSlo3 (KCa5.1) channels induced by voltage pulses, with an IC50 value of 169 μM. Quinine hemisulfate hydrate serves as a fluorescence standard reference substance with fluorescence spectrum calibration and validation activity.
For research use only. We do not sell to patients.
- Purity: 99.42%
- CAS No.: 207671-44-1
- Formula: C20H24N2O2.1/2H2O4S.H2O
- Molecular Weight:391.48
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Quinine hemisulfate hydrate
More- Neurosci Bull. 2025 May 6. [Abstract]
- Cell Mol Life Sci. 2025 Nov 25;82(1):419. [Abstract]
- J Mol Cell Biol. 2025 May 22;16(11):mjae051. [Abstract]
- ACS Omega. 2024 Feb 28;9(10):11870-11882. [Abstract]
- Mol Med Rep. 2021 May;23(5):313. [Abstract]
- Vet Microbiol. 2026 May:316:110992. [Abstract]
- Norwegian University of Science and Technology. 2019 Sep.
All Parasite Isoforms
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Biological Activity
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Plasmodium |
Quinine sulfate dihydrate serves as a fluorescence standard reference material[1].
Quinine (150 μM, 30 min) sulfate dihydrate inhibits the proliferation of dengue virus (DENV) and the cytostatic effect in the human hepatoma HepG2 cell line[2].
Quinine (37.5-150 μM, 24 hours) sulfate dihydrate significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in the human hepatoma HepG2 cell line[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Quinine (administered via gavage at 10 mg/kg once daily for 8 weeks) sulfate dihydrate reduces the activities of SOD, CAT and GSH, enzymes of the antioxidant defense system, in testicular tissues of adult male albino rats[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 207671-44-1
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Appearance Solid
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Molecular Weight 391.48
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Formula C20H24N2O2.1/2H2O4S.H2O
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Color White to off-white
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SMILES
[H][C@@]1([C@H](O)C2=CC=NC3=C2C=C(OC)C=C3)C[C@H]4[C@@H](C=C)C[N@@]1CC4.OS(O)(=O)=O.O.[1/2]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (7)
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Journal Impact Factor
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Most Recent
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Neurosci Bull
A Novel Functional Method of Protector Screening for Zebrafish Lateral Line Hair Cells via the Acoustic Escape Response. [Abstract]2025 May 6. PMID: 40329138 -
Cell Mol Life Sci
2025 Nov 25;82(1):419. PMID: 41288707 -
J Mol Cell Biol
2025 May 22;16(11):mjae051. PMID: 39848918 -
ACS Omega
Identification of New Modulators and Inhibitors of Palmitoyl-Protein Thioesterase 1 for CLN1 Batten Disease and Cancer. [Abstract]2024 Feb 28;9(10):11870-11882. PMID: 38496939 -
Mol Med Rep
2021 May;23(5):313. PMID: 34240224 -
Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
Solvent & Solubility
H2O : 4 mg/mL (10.22 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (394 KB)
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References
[3]. Ebenezer O Farombi, et al. Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of quinine sulfate in rats. J Basic Clin Physiol Pharmacol. 2012 Feb 27;23(1):39-44. [Content Brief]
[4]. Jane Achan, et al. Quinine, an Old Anti-Malarial Drug in a Modern World: Role in the Treatment of Malaria. Malar J. 2011 May 24;10:144. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.5544 mL | 12.7720 mL | 25.5441 mL | 63.8602 mL |
| 5 mM | 0.5109 mL | 2.5544 mL | 5.1088 mL | 12.7720 mL | |
| 10 mM | 0.2554 mL | 1.2772 mL | 2.5544 mL | 6.3860 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Quinine hemisulfate hydrate Related Classifications
HY-D0143B Related Classifications
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