Quinine hydrochloride dihydrate
Based on 7 publication(s) in Google Scholar
Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM.
For research use only. We do not sell to patients.
- Purity: 99.74%
- CAS No.: 6119-47-7
- Formula: C20H29ClN2O4
- Molecular Weight:396.91
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Quinine hydrochloride dihydrate
More- Neurosci Bull. 2025 May 6. [Abstract]
- Cell Mol Life Sci. 2025 Nov 25;82(1):419. [Abstract]
- J Mol Cell Biol. 2025 May 22;16(11):mjae051. [Abstract]
- ACS Omega. 2024 Feb 28;9(10):11870-11882. [Abstract]
- Mol Med Rep. 2021 May;23(5):313. [Abstract]
- Vet Microbiol. 2026 May:316:110992. [Abstract]
- Norwegian University of Science and Technology. 2019 Sep.
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In Vivo Efficacy Study
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Cell Imaging/Staining
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Cell Proliferation/Viability Assay
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Biological Activity
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Plasmodium |
Quinine hydrochloride dihydrate (150 μM, 30 min) inhibits the proliferation and cytostatic effects of DENV (Dengue virus) in human hepatocarcinoma HepG2 cell line[1].
Quinine hydrochloride dihydrate (37.5-150 μM, 24 hours) significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in human hepatocarcinoma HepG2 cell line[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human hepatocarcinoma cell line(HepG2)
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Concentration:150 μM
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Incubation Time:30 min
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Result:Inhibited DENV virus replication with 19% yield compared to untreated. Reduced DENV-positive cells from 23.28% to 12.05% in a dose-dependent manner.
Quinine hydrochloride dihydrate (oral gavage, 10 mg/kg, everyday, 8 weeks) causes a decrease in the antioxidant defense system of rat testicular tissue such as SOD, CAT and GSH enzyme activity in male adult albino rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss albino mice 7-8-weeks (weighing 24 g)[2]
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Dosage:Swiss albino mice 7-8-weeks (weighing 24 g)[2]
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Administration:Oral gavage; every week; 16 weeks
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Result:Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg.
Chemical Information
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CAS No. 6119-47-7
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Appearance Solid
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Molecular Weight 396.91
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Formula C20H29ClN2O4
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Color White to off-white
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SMILES
COC1=CC2=C(N=CC=C2[C@H]([C@@]3([H])[N@](C[C@@H]4C=C)CC[C@@]4([H])C3)O)C=C1.Cl.O.O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (7)
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Journal Impact Factor
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Most Recent
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Neurosci Bull
A Novel Functional Method of Protector Screening for Zebrafish Lateral Line Hair Cells via the Acoustic Escape Response. [Abstract]2025 May 6. PMID: 40329138
Quinine hydrochloride dihydrate purchased from MedChemExpress. Usage Cited in: Neurosci Bull. 2025 May 6. [Abstract]
Quinine (qui; 10 μM; 5 min) decreased the travel distance upon sound stimulation in zebrafish.
Quinine hydrochloride dihydrate purchased from MedChemExpress. Usage Cited in: Neurosci Bull. 2025 May 6. [Abstract]
Quinine (qui; 10 μM; 5 min) remained unchanged in the number of HCs in zebrafish.
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Cell Mol Life Sci
2025 Nov 25;82(1):419. PMID: 41288707
Quinine hydrochloride dihydrate purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2025 Nov 25;82(1):419. [Abstract]
Quinine (0-320 μM) showed no cytotoxicity for Primary pancreatic β cells.
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J Mol Cell Biol
2025 May 22;16(11):mjae051. PMID: 39848918
Quinine hydrochloride dihydrate purchased from MedChemExpress. Usage Cited in: J Mol Cell Biol. 2025 May 22;16(11):mjae051. [Abstract]
Quinine (0-320 μM; 24 h) showed cytotoxicity in primary pancreatic β cells and HEK293T cells.
Quinine hydrochloride dihydrate purchased from MedChemExpress. Usage Cited in: J Mol Cell Biol. 2025 May 22;16(11):mjae051. [Abstract]
Quinine (0-40 μM) potentiated high glucose (25 mM)-evoked insulin secretion in a dose-dependent manner at 5–100 μM. However, under low-glucose (2 mM) conditions, quinine induced insulin secretion only at concentrations of 50–100 μM; without the addition of glucose, 5 μM quinine alone was not sufficient to stimulate insulin secretion.
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ACS Omega
Identification of New Modulators and Inhibitors of Palmitoyl-Protein Thioesterase 1 for CLN1 Batten Disease and Cancer. [Abstract]2024 Feb 28;9(10):11870-11882. PMID: 38496939 -
Mol Med Rep
2021 May;23(5):313. PMID: 34240224 -
Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
Solvent & Solubility
DMSO : ≥ 100 mg/mL (251.95 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 20 mg/mL (50.39 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 2.6 mg/mL (6.55 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Purity & Documentation
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Data Sheet (283 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Shilu Malakar，et al. Drug repurposing of quinine as antiviral against dengue virus infection. Virus Res. 2018 Aug 15;255:171-178. doi: 10.1016/j.virusres.2018.07.018. Epub 2018 Jul 25. [Content Brief]
[3]. Ebenezer O Farombi, et al. Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of quinine sulfate in rats. J Basic Clin Physiol Pharmacol. 2012 Feb 27;23(1):39- [Content Brief]
[4]. White, N.J., et al., Quinine pharmacokinetics and toxicity in cerebral and uncomplicated Falciparum malaria. Am J Med, 1982. 73(4): p. 564-72. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.5195 mL | 12.5973 mL | 25.1946 mL | 62.9866 mL |
| 5 mM | 0.5039 mL | 2.5195 mL | 5.0389 mL | 12.5973 mL | |
| 10 mM | 0.2519 mL | 1.2597 mL | 2.5195 mL | 6.2987 mL | |
| 15 mM | 0.1680 mL | 0.8398 mL | 1.6796 mL | 4.1991 mL | |
| 20 mM | 0.1260 mL | 0.6299 mL | 1.2597 mL | 3.1493 mL | |
| 25 mM | 0.1008 mL | 0.5039 mL | 1.0078 mL | 2.5195 mL | |
| 30 mM | 0.0840 mL | 0.4199 mL | 0.8398 mL | 2.0996 mL | |
| 40 mM | 0.0630 mL | 0.3149 mL | 0.6299 mL | 1.5747 mL | |
| 50 mM | 0.0504 mL | 0.2519 mL | 0.5039 mL | 1.2597 mL | |
| DMSO | 60 mM | 0.0420 mL | 0.2100 mL | 0.4199 mL | 1.0498 mL |
| 80 mM | 0.0315 mL | 0.1575 mL | 0.3149 mL | 0.7873 mL | |
| 100 mM | 0.0252 mL | 0.1260 mL | 0.2519 mL | 0.6299 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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