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  3. Quinine hydrochloride dihydrate

Quinine hydrochloride dihydrate 

Cat. No.: HY-B0433A Purity: 99.79%
Handling Instructions

Quinine Hydrochloride Dihydrate is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), anti-inflammatory properties and a bitter taste.

For research use only. We do not sell to patients.

Quinine hydrochloride dihydrate Chemical Structure

Quinine hydrochloride dihydrate Chemical Structure

CAS No. : 6119-47-7

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 79 In-stock
Estimated Time of Arrival: December 31
5 g USD 72 In-stock
Estimated Time of Arrival: December 31
10 g USD 108 In-stock
Estimated Time of Arrival: December 31
50 g   Get quote  

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Description

Quinine Hydrochloride Dihydrate is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), anti-inflammatory properties and a bitter taste. Target: Antiparasitic Quinine is a natural white crystalline alkaloid having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), and anti-inflammatory properties and a bitter taste. It is a stereoisomer of quinidine, which, unlike quinine, is an antiarrhythmic. Quinine contains two major fused-ring systems: the aromatic quinoline and the bicyclic quinuclidine. In patients with cerebral malaria receiving the standard dose of 10 mg/kg every eight hours, plasma quinine concentrations consistently exceeded 10 mg/liter, reaching a peak 60 ± 25 hours (mean ± 1 S.D.) after treatment was begun and then declining. Quinine total clearances (CI) and total apparent volumes of distribution (Vd) were significantly lower than in uncomplicated malaria (CI, 0.92 ± 0.42 compared with 1.35 ± 0.6 ml/min/kg, p = 0.03; Vd, 1.18 ± 0.37 compared with 1.67 ± 0.34 liter/kg, p = 0.0013) [1].

Molecular Weight

396.91

Formula

C₂₀H₂₉ClN₂O₄

CAS No.

6119-47-7

SMILES

COC1=CC2=C(N=CC=C2[[email protected]]([[email protected]@]3([H])[[email protected]](C[[email protected]@H]4C=C)CC[[email protected]@]4([H])C3)O)C=C1.Cl.O.O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (251.95 mM)

H2O : 20 mg/mL (50.39 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5195 mL 12.5973 mL 25.1946 mL
5 mM 0.5039 mL 2.5195 mL 5.0389 mL
10 mM 0.2519 mL 1.2597 mL 2.5195 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Quinine hydrochloride dihydrate
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HY-B0433A
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