2. Inflammation/Immunology

Inflammation/Immunology (炎症/免疫)

Inflammation/Immunology

関連製品

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

製品番号 製品名 CAS 番号 純度 構造式
  • HY-N8579
    Eugenyl benzoate 531-26-0
    Eugenyl benzoate has the potency for scavenging of DPPH radical. Eugenyl Benzoate Derivatives can be used for development of BCL-2 inhibitors.
    Eugenyl benzoate
  • HY-N8690
    4,2'-Dihydroxy-4'-methoxychalcone 63529-06-6 98%
    4,2'-Dihydroxy-4'-methoxychalcone, a chalcone, shows allergy-preventive effects.
    4,2'-Dihydroxy-4'-methoxychalcone
  • HY-N8691
    2',6'-Dihydroxy-4'-methoxydihydrochalcone 35241-55-5 98%
    2',6'-Dihydroxy-4'-methoxydihydrochalcone is an orally active dihydrochalcone compound with antiplasmodial and anti-inflammatory activities. 2',6'-Dihydroxy-4'-methoxydihydrochalcone reduces the IL-1β, TNF, and nitrite levels in vitro.
    2',6'-Dihydroxy-4'-methoxydihydrochalcone
  • HY-N8802
    (-)-Epicatechin 3-(3-O-methylgallate) 83104-86-3 98%
    (-)-Epicatechin 3-(3-O-methylgallate) is a catechin, that can be isolated from tea leaf. (-)-Epicatechin 3-(3-O-methylgallate) shows anti-inflammatory activity.
    (-)-Epicatechin 3-(3-O-methylgallate)
  • HY-N8811
    Acetyl 11α-methoxy-β-boswellic acid 918548-43-3 98%
    Acetyl 11α-methoxy-β-boswellic acid is a terpenoid compound derived from the resin of olive plants, and it holds promise for research in fields such as anti-inflammatory, anti-cancer, and analgesic applications.
    Acetyl 11α-methoxy-β-boswellic acid
  • HY-N8818
    3-Acetoxytirucalla-7,24-dien-21-oic acid 98166-55-3 98%
    3-Acetoxytirucalla-7,24-dien-21-oic acid, derived from Boswellia carteri, exhibits anti-inflammatory activity. Its ID50 for Phorbol 12-myristate 13-acetate (HY-18739)-induced ear swelling in mice is 0.06 mg per ear. 3-Acetoxytirucalla-7,24-dien-21-oic acid holds potential for research in the field of inflammation.
    3-Acetoxytirucalla-7,24-dien-21-oic acid
  • HY-N8862
    Anti-inflammatory agent 69 80514-14-3 98%
    Anti-inflammatory agent 69 (compound 12), sesquiterpenoid, is an anti-inflammatory agent isolated from the dried flower buds of Tussilago farfara. Anti-inflammatory agent 69 can inhibit the NO production with IC50 value of 24 μM.
    Anti-inflammatory agent 69
  • HY-N8955
    Maritimein 490-54-0 98%
    Maritimein is an aurone glucoside and antioxidant with free radical scavenger activity, found in Coreopsis tinctoria Nutt.Maritimein scavenges ABTS•+ radical cations.
    Maritimein
  • HY-N9104
    ent-Labda-8(17),13Z-diene-15,16,19-triol 19-O-glucoside 1245636-01-4 98%
    ent-Labda-8(17),13Z-diene-15,16,19-triol 19-O-glucoside is a natural product derived from the leaves of Andrographis paniculata that has anti-inflammatory and antiviral activity.
    ent-Labda-8(17),13Z-diene-15,16,19-triol 19-O-glucoside
  • HY-N9149
    Cryptanoside A 98570-81-1 98%
    Cryptanoside A, a cardiac glycoside epoxide, can be isolated from the stems of Cryptolepis dubia. Cryptanoside A has potent cytotoxicity against cancer cells. Cryptanoside A also inhibits Na+/K+-ATPase activity. Cryptanoside A increases the expression of Akt and the p65 subunit of NF-κB.
    Cryptanoside A
  • HY-N9164
    Hecubine 62874-52-6 98%
    Hecubine is a monoterpene indole alkaloid found in Ervatamia ocinalis. Hecubine activates TREM2 expression, reduces LPS (HY-D1056)-stimulated inammatory cytokines (TNF-α、IL-6、IL-1β) overexpression, as well as suppresses the levels of TLR4-, MyD88-, MAPK/PI3K/AKT- and NF-κB-related proteins. Hecubin also exhibits antioxidative effect, reduces ROS production and activates of the Nrf2/HO-1 pathway. Hecubine rescues LPS-induced behavioral deficits in zebrash larvae. Hecubine can be used for the research of neural inflammation-associated central nervous system diseases.
    Hecubine
  • HY-N9492
    (+)-2-Carene

    (+)-2-カレン

    		4497-92-1 98%
    4497-92-1
    (+)-2-Carene
  • HY-N9503
    Carvacryl acetate 6380-28-5 99.80%
    Carvacryl acetate is an orally active and brain-penetrant TRPA1 receptor activator and Na+/K+-ATPase activator. Carvacryl acetate modulates GABAergic signaling, alters hippocampal GABA and glutamine levels, reduces lipid peroxidation and nitrite formation, scavenges hydroxyl radicals, and boosts glutathione and antioxidant enzyme activity. Carvacryl acetate inhibits Haemonchus contortus larval hatching, development, adult motility, and fecal egg counts, and induces adult worm structural damage. Carvacryl acetate can be used for the research of intestinal mucositis, gastrointestinal nematode infection, epilepsy, and neurodegenerative diseases.
    Carvacryl acetate
  • HY-N9541
    Chaetoglobosin Vb 1399690-75-5 98%
    Chaetoglobosin Vb is a novel cytotoxic alkaloid with anti-inflammatory and antioxidant activities. Chaetoglobosin Vb can inhibit oxidative stress induced by LPS stimulation, reduce the production of reactive oxygen species and increase the expression of the antioxidant enzyme superoxide dismutase (SOD). Chaetoglobosin Vb significantly reduced the gene and protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) induced by LPS, and alleviated the production of proinflammatory cytokines such as TNF-α, IL-6 and IL-1β. Chaetoglobosin Vb exerts its biological activity through the TLR4-mediated MyD88-dependent signaling pathway and the TRIF-dependent signaling pathway, which is specifically manifested by inhibiting the phosphorylation of p38, ERK, and JNK MAPK and the translocation of NF-κB p65 subunit to the nucleus. Chaetoglobosin Vb showed no cytotoxic effect in the concentration range of 25-100 μM and promoted SOD enzyme activity and phosphorylation of p38, ERK1/2 and JNK in a dose-dependent manner.
    Chaetoglobosin Vb
  • HY-N9554
    WIN-64821 150881-27-9 98%
    WIN-64821 is a secondary metabolite produced by Aspergillus species, and acts as a Neurokinin Receptor antagonist. The Ki values of WIN-64821 for NK1, NK2 and NK3 receptors are 0.24 (human astrocytoma cells), 0.26 (rat duodenum) and 15.2 (guinea pig forebrain) μM, respectively. WIN-64821 inhibits apamin-induced contraction of rat vas deferens, blocks substance P-induced contraction of guinea pig ileum and Ca2+ efflux in human astrocytoma cells. WIN-64821 is applicable to analgesic and anti-inflammatory research.
    WIN-64821
  • HY-N9686
    Caffeoyl-CoA 53034-79-0 98%
    Caffeoyl-CoA is a substrate of Chalcone synthase derived from rye with a Km value of 1.45 μM.
    Caffeoyl-CoA
  • HY-N9754
    Cyclosporin L 108027-39-0 98%
    Cyclosporin L is a cyclosporin that can be found in Tolypocladium inflatum, with moderate immunosuppressive and antifungal activities.
    Cyclosporin L
  • HY-N9866
    Grasshopper ketone 41703-38-2 98%
    It is a bioactive compound with anti-inflammatory activity that inhibits LPS-induced NO production in RAW 264.7 cells and acts by inhibiting the phosphorylation of MAPK (ERK, JNK and p38) and NF-κB p65. Grasshopper ketone, as an ingredient, has shown its potential in anti-inflammatory inhibition.
    Grasshopper ketone
  • HY-N9896
    Anhydronotoptol 88206-51-3 98%
    Anhydronotoptol is a potent nitric oxide inhibitory coumarin. Anhydronotoptol inhibits NO production in RAW 264.7 cells induced by LPS with an IC50 value of 36.6 μM.
    Anhydronotoptol
  • HY-N9953
    Chrysophanol 8-O-β-D-(6′-O-galloyl)glucopyranoside 266997-57-3 98%
    Chrysophanol 8-O-β-D-(6’-O-galloyl)glucopyranoside, an anthraquinone glucoside, can be isolated from Rheum undulatum L. Chrysophanol 8-O-β-D-(6’-O-galloyl)glucopyranoside has potent DPPH radical and ?O2- scavenging activity.
    Chrysophanol 8-O-β-D-(6′-O-galloyl)glucopyranoside
製品番号 製品名 / Synonyms Application Reactivity